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Health-related quality of life after interventional or conservative strategy in patients with unstable angina or non-ST-segment elevation myocardial infarction: one-year results of the third Randomized Intervention Trial of unstable Angina (RITA-3).
J Am Coll Cardiol. 2005 Jan 18; 45(2):221-8.JACC

Abstract

OBJECTIVES

We sought to compare the effects of an early interventional strategy (IS) versus a conservative strategy (CS) on health-related quality of life (HRQOL) in patients with non-ST-segment elevation acute coronary syndromes (ACS).

BACKGROUND

The third Randomized Intervention Trial of unstable Angina (RITA-3) evaluated early IS (n = 895) versus CS (n = 915). We report one-year results of the RITA-3 trial concerning HRQOL.

METHODS

The patients' HRQOL was assessed with the Short Form-36 (SF-36) and Seattle Angina Questionnaire (SAQ) at four-month and one-year follow-up, and the EuroQOL Visual Analogue Scale (EQ-VAS) and EuroQOL 5-Dimensional Classification (EQ-5D) also measured at baseline. Analysis was performed using the two-sample t test and analysis of co-variance.

RESULTS

Mean changes from baseline EQ-VAS scores were better for IS than for CS at four months (treatment difference of 3.0, p < 0.001) and one year (2.3, p < 0.01). The EQ-5D utility scores were also higher for IS at four months (treatment difference: 0.036, p < 0.01) and at one year (0.016, p = 0.20). For SF-36, IS scored significantly better at four months for physical function, physical role function, emotional role function, social function, vitality, and general health. The SAQ scores for exertional capacity, anginal stability and frequency, treatment satisfaction, and disease perception were better for IS at four months. These treatment differences were present but attenuated by one-year follow-up. Improvements in HRQOL for IS could be attributed to improvements in anginal symptoms.

CONCLUSIONS

In patients with non-ST-segment elevation ACS, an early IS provides greater gains in HRQOL, as compared with CS, mainly due to improvements in angina grade.

Authors+Show Affiliations

Medical Statistics Unit, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. joseph.kim@lshtm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15653019

Citation

Kim, Joseph, et al. "Health-related Quality of Life After Interventional or Conservative Strategy in Patients With Unstable Angina or non-ST-segment Elevation Myocardial Infarction: One-year Results of the Third Randomized Intervention Trial of Unstable Angina (RITA-3)." Journal of the American College of Cardiology, vol. 45, no. 2, 2005, pp. 221-8.
Kim J, Henderson RA, Pocock SJ, et al. Health-related quality of life after interventional or conservative strategy in patients with unstable angina or non-ST-segment elevation myocardial infarction: one-year results of the third Randomized Intervention Trial of unstable Angina (RITA-3). J Am Coll Cardiol. 2005;45(2):221-8.
Kim, J., Henderson, R. A., Pocock, S. J., Clayton, T., Sculpher, M. J., & Fox, K. A. (2005). Health-related quality of life after interventional or conservative strategy in patients with unstable angina or non-ST-segment elevation myocardial infarction: one-year results of the third Randomized Intervention Trial of unstable Angina (RITA-3). Journal of the American College of Cardiology, 45(2), 221-8.
Kim J, et al. Health-related Quality of Life After Interventional or Conservative Strategy in Patients With Unstable Angina or non-ST-segment Elevation Myocardial Infarction: One-year Results of the Third Randomized Intervention Trial of Unstable Angina (RITA-3). J Am Coll Cardiol. 2005 Jan 18;45(2):221-8. PubMed PMID: 15653019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life after interventional or conservative strategy in patients with unstable angina or non-ST-segment elevation myocardial infarction: one-year results of the third Randomized Intervention Trial of unstable Angina (RITA-3). AU - Kim,Joseph, AU - Henderson,Robert A, AU - Pocock,Stuart J, AU - Clayton,Tim, AU - Sculpher,Mark J, AU - Fox,Keith A A, AU - ,, PY - 2004/06/07/received PY - 2004/09/16/revised PY - 2004/10/04/accepted PY - 2005/1/18/pubmed PY - 2005/2/23/medline PY - 2005/1/18/entrez SP - 221 EP - 8 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 45 IS - 2 N2 - OBJECTIVES: We sought to compare the effects of an early interventional strategy (IS) versus a conservative strategy (CS) on health-related quality of life (HRQOL) in patients with non-ST-segment elevation acute coronary syndromes (ACS). BACKGROUND: The third Randomized Intervention Trial of unstable Angina (RITA-3) evaluated early IS (n = 895) versus CS (n = 915). We report one-year results of the RITA-3 trial concerning HRQOL. METHODS: The patients' HRQOL was assessed with the Short Form-36 (SF-36) and Seattle Angina Questionnaire (SAQ) at four-month and one-year follow-up, and the EuroQOL Visual Analogue Scale (EQ-VAS) and EuroQOL 5-Dimensional Classification (EQ-5D) also measured at baseline. Analysis was performed using the two-sample t test and analysis of co-variance. RESULTS: Mean changes from baseline EQ-VAS scores were better for IS than for CS at four months (treatment difference of 3.0, p < 0.001) and one year (2.3, p < 0.01). The EQ-5D utility scores were also higher for IS at four months (treatment difference: 0.036, p < 0.01) and at one year (0.016, p = 0.20). For SF-36, IS scored significantly better at four months for physical function, physical role function, emotional role function, social function, vitality, and general health. The SAQ scores for exertional capacity, anginal stability and frequency, treatment satisfaction, and disease perception were better for IS at four months. These treatment differences were present but attenuated by one-year follow-up. Improvements in HRQOL for IS could be attributed to improvements in anginal symptoms. CONCLUSIONS: In patients with non-ST-segment elevation ACS, an early IS provides greater gains in HRQOL, as compared with CS, mainly due to improvements in angina grade. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15653019/Health_related_quality_of_life_after_interventional_or_conservative_strategy_in_patients_with_unstable_angina_or_non_ST_segment_elevation_myocardial_infarction:_one_year_results_of_the_third_Randomized_Intervention_Trial_of_unstable_Angina__RITA_3__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(04)02066-2 DB - PRIME DP - Unbound Medicine ER -