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Association between functioning in adolescence prior to first admission for schizophrenia and affective disorders and patterns of hospitalizations thereafter.
Schizophr Res. 2005 Mar 01; 73(2-3):185-91.SR

Abstract

BACKGROUND

Kraepelin and Blueler suggested that subtle manifestations of schizophrenia are present in some persons for many years before formal diagnosis and that the severity of these is associated with outcomes in schizophrenia. Empirical support for this hypothesis comes primarily from small samples using retrospectively collected data.

AIMS

We tested this hypothesis, for the first time, using a population-based cohort.

METHOD

The Israeli Draft Board Registry, which contains measures of intellectual and behavioral functioning for the unselected population of 17-year-olds, was merged with the National Psychiatric Hospitalization Case Registry that contains data on all psychiatric hospitalizations. The database was used to identify adolescents assessed by the draft board at least 1 year prior to their first hospitalization for schizophrenia (n=996) or affective disorder (n=335).

RESULTS

Poorer social functioning and organizational ability prior to first admission were associated with more days per year in the hospital for the male schizophrenia group. There were no significant correlations between days per year in the hospital and any of the behavioral functioning measures for the affective group. Among females the higher the previous level of intellectual functioning the fewer the days per year in the hospital in both the schizophrenia group and affective groups. For males no such correlations were evident. The comparisons between patients who had one as opposed to more than one admission found that in both diagnostic groups female patients with one admission had higher pre-first hospitalization intellectual functioning.

CONCLUSIONS

Gender and disease specific premorbid deficits have may have differential prognostic value for outcomes in schizophrenia and affective disorders.

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Authors+Show Affiliations

Rabinowitz J
Bar Ilan University, Ramat Gan, Israel. rabinowz@mail.biu.ac.il
Haim R
No affiliation info available
Reichenberg A
No affiliation info available
Weiser M
No affiliation info available
Kaplan Z
No affiliation info available
Davidson M
No affiliation info available
Häfner H
No affiliation info available

MeSH

AdolescentFemaleHospitalizationHumansMaleMood DisordersPatient AdmissionRegistriesRetrospective StudiesSchizophreniaSeverity of Illness IndexTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15653261

Citation

Rabinowitz, Jonathan, et al. "Association Between Functioning in Adolescence Prior to First Admission for Schizophrenia and Affective Disorders and Patterns of Hospitalizations Thereafter." Schizophrenia Research, vol. 73, no. 2-3, 2005, pp. 185-91.
Rabinowitz J, Haim R, Reichenberg A, et al. Association between functioning in adolescence prior to first admission for schizophrenia and affective disorders and patterns of hospitalizations thereafter. Schizophr Res. 2005;73(2-3):185-91.
Rabinowitz, J., Haim, R., Reichenberg, A., Weiser, M., Kaplan, Z., Davidson, M., & Häfner, H. (2005). Association between functioning in adolescence prior to first admission for schizophrenia and affective disorders and patterns of hospitalizations thereafter. Schizophrenia Research, 73(2-3), 185-91.
Rabinowitz J, et al. Association Between Functioning in Adolescence Prior to First Admission for Schizophrenia and Affective Disorders and Patterns of Hospitalizations Thereafter. Schizophr Res. 2005 Mar 1;73(2-3):185-91. PubMed PMID: 15653261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between functioning in adolescence prior to first admission for schizophrenia and affective disorders and patterns of hospitalizations thereafter. AU - Rabinowitz,Jonathan, AU - Haim,Rachel, AU - Reichenberg,Abraham, AU - Weiser,Mark, AU - Kaplan,Zeev, AU - Davidson,Michael, AU - Häfner,Heinz, PY - 2004/07/31/received PY - 2004/08/06/revised PY - 2004/08/16/accepted PY - 2005/1/18/pubmed PY - 2005/6/10/medline PY - 2005/1/18/entrez SP - 185 EP - 91 JF - Schizophrenia research JO - Schizophr Res VL - 73 IS - 2-3 N2 - BACKGROUND: Kraepelin and Blueler suggested that subtle manifestations of schizophrenia are present in some persons for many years before formal diagnosis and that the severity of these is associated with outcomes in schizophrenia. Empirical support for this hypothesis comes primarily from small samples using retrospectively collected data. AIMS: We tested this hypothesis, for the first time, using a population-based cohort. METHOD: The Israeli Draft Board Registry, which contains measures of intellectual and behavioral functioning for the unselected population of 17-year-olds, was merged with the National Psychiatric Hospitalization Case Registry that contains data on all psychiatric hospitalizations. The database was used to identify adolescents assessed by the draft board at least 1 year prior to their first hospitalization for schizophrenia (n=996) or affective disorder (n=335). RESULTS: Poorer social functioning and organizational ability prior to first admission were associated with more days per year in the hospital for the male schizophrenia group. There were no significant correlations between days per year in the hospital and any of the behavioral functioning measures for the affective group. Among females the higher the previous level of intellectual functioning the fewer the days per year in the hospital in both the schizophrenia group and affective groups. For males no such correlations were evident. The comparisons between patients who had one as opposed to more than one admission found that in both diagnostic groups female patients with one admission had higher pre-first hospitalization intellectual functioning. CONCLUSIONS: Gender and disease specific premorbid deficits have may have differential prognostic value for outcomes in schizophrenia and affective disorders. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/15653261/Association_between_functioning_in_adolescence_prior_to_first_admission_for_schizophrenia_and_affective_disorders_and_patterns_of_hospitalizations_thereafter_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(04)00294-4 DB - PRIME DP - Unbound Medicine ER -