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Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients.
Am J Med Sci 2005; 329(1):1-5AJ

Abstract

BACKGROUND

Depression, which is the most common psychological complication in patients with end-stage renal disease (ESRD), has an impact on the clinical outcome and is associated with malnutrition in chronic hemodialysis patients. This study evaluated the effect of antidepression treatment on nutritional status in depressed chronic hemodialysis patients.

METHODS

Sixty-two ESRD patients who underwent dialysis for more than 6 months were interviewed and completed a Beck Depression Inventory assessment. Thirty-four patients who had scores greater than 18 on the Beck Depression Inventory score and met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria for major depressive disorder were selected to receive paroxetine 10 mg/day and psychotherapy for 8 weeks. The remaining 28 patients were assigned to the control group. Change in the severity of depressive symptoms was ascertained by administering the Hamilton Depression Rating Scale. Nutritional status was evaluated by normalized protein catabolic rate, serum albumin and blood urea nitrogen level.

RESULTS

All patients successfully completed 8 weeks of antidepression treatment. Antidepression treatment decreased the severity of depressive symptoms (Hamilton Depression Rating Scale score: 16.6 +/- 7.0 versus 15.1 +/- 6.6, P < 0.01) and increased normalized protein catabolic rate (1.04 +/- 0.24 versus 1.17 +/- 0.29 g/kg/day, P < 0.05), serum albumin (37.3 +/- 2.0 versus 38.7 +/- 3.2 g/l, P < 0.005), and prehemodialysis blood urea nitrogen level (24.3 +/- 5.6 versus 30.2 +/- 7.9 mmol/L, P < 0.001). In the control group, no change was noted during the study period.

CONCLUSION

This study suggests that antidepressant medication with supportive psychotherapy can successfully treat depression and improve nutritional status in chronic hemodialysis patients with depression.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, College of Medicine, Hallym University, Chunchon, Kangwon Do, South Korea. jrkoo@hallym.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15654172

Citation

Koo, Ja-Ryong, et al. "Treatment of Depression and Effect of Antidepression Treatment On Nutritional Status in Chronic Hemodialysis Patients." The American Journal of the Medical Sciences, vol. 329, no. 1, 2005, pp. 1-5.
Koo JR, Yoon JY, Joo MH, et al. Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients. Am J Med Sci. 2005;329(1):1-5.
Koo, J. R., Yoon, J. Y., Joo, M. H., Lee, H. S., Oh, J. E., Kim, S. G., ... Son, B. K. (2005). Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients. The American Journal of the Medical Sciences, 329(1), pp. 1-5.
Koo JR, et al. Treatment of Depression and Effect of Antidepression Treatment On Nutritional Status in Chronic Hemodialysis Patients. Am J Med Sci. 2005;329(1):1-5. PubMed PMID: 15654172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients. AU - Koo,Ja-Ryong, AU - Yoon,Jong-Yoo, AU - Joo,Min-Ha, AU - Lee,Hyung-Seok, AU - Oh,Ji-Eun, AU - Kim,Seong-Gyun, AU - Seo,Jang-Won, AU - Lee,Young-Ki, AU - Kim,Hyung-Jik, AU - Noh,Jung-Woo, AU - Lee,Sang-Kyu, AU - Son,Bong-Ki, PY - 2005/1/18/pubmed PY - 2005/2/26/medline PY - 2005/1/18/entrez SP - 1 EP - 5 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 329 IS - 1 N2 - BACKGROUND: Depression, which is the most common psychological complication in patients with end-stage renal disease (ESRD), has an impact on the clinical outcome and is associated with malnutrition in chronic hemodialysis patients. This study evaluated the effect of antidepression treatment on nutritional status in depressed chronic hemodialysis patients. METHODS: Sixty-two ESRD patients who underwent dialysis for more than 6 months were interviewed and completed a Beck Depression Inventory assessment. Thirty-four patients who had scores greater than 18 on the Beck Depression Inventory score and met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria for major depressive disorder were selected to receive paroxetine 10 mg/day and psychotherapy for 8 weeks. The remaining 28 patients were assigned to the control group. Change in the severity of depressive symptoms was ascertained by administering the Hamilton Depression Rating Scale. Nutritional status was evaluated by normalized protein catabolic rate, serum albumin and blood urea nitrogen level. RESULTS: All patients successfully completed 8 weeks of antidepression treatment. Antidepression treatment decreased the severity of depressive symptoms (Hamilton Depression Rating Scale score: 16.6 +/- 7.0 versus 15.1 +/- 6.6, P < 0.01) and increased normalized protein catabolic rate (1.04 +/- 0.24 versus 1.17 +/- 0.29 g/kg/day, P < 0.05), serum albumin (37.3 +/- 2.0 versus 38.7 +/- 3.2 g/l, P < 0.005), and prehemodialysis blood urea nitrogen level (24.3 +/- 5.6 versus 30.2 +/- 7.9 mmol/L, P < 0.001). In the control group, no change was noted during the study period. CONCLUSION: This study suggests that antidepressant medication with supportive psychotherapy can successfully treat depression and improve nutritional status in chronic hemodialysis patients with depression. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/15654172/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)33923-9 DB - PRIME DP - Unbound Medicine ER -