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Hair follicle pigmentation.
J Invest Dermatol. 2005 Jan; 124(1):13-21.JI

Abstract

Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts. This activity is in turn regulated by an array of enzymes, structural and regulatory proteins, transporters, and receptors and their ligands, acting on the developmental stages, cellular, and hair follicle levels. FM is stringently coupled to the anagen stage of the hair cycle, being switched-off in catagen to remain absent through telogen. At the organ level FM is precisely coupled to the life cycle of melanocytes with changes in their compartmental distribution and accelerated melanoblast/melanocyte differentiation with enhanced secretory activity. The melanocyte compartments in the upper hair follicle also provides a reservoir for the repigmentation of epidermis and, for the cyclic formation of new anagen hair bulbs. Melanin synthesis and pigment transfer to bulb keratinocytes are dependent on the availability of melanin precursors, and regulation by signal transduction pathways intrinsic to skin and hair follicle, which are both receptor dependent and independent, act through auto-, para- or intracrine mechanisms and can be modified by hormonal signals. The important regulators are MC1 receptor its and adrenocorticotropic hormone, melanocyte stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endothelin receptors with their ligands. Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color.

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Authors+Show Affiliations

Slominski A
Department of Pathology, University of Tennessee, Memphis, Tennessee 38163, USA. aslominski@utmem.edu
Wortsman J
No affiliation info available
Plonka PM
No affiliation info available
Schallreuter KU
No affiliation info available
Paus R
No affiliation info available
Tobin DJ
No affiliation info available

MeSH

AnimalsHair ColorHair FollicleHumansMelanocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15654948

Citation

Slominski, Andrzej, et al. "Hair Follicle Pigmentation." The Journal of Investigative Dermatology, vol. 124, no. 1, 2005, pp. 13-21.
Slominski A, Wortsman J, Plonka PM, et al. Hair follicle pigmentation. J Invest Dermatol. 2005;124(1):13-21.
Slominski, A., Wortsman, J., Plonka, P. M., Schallreuter, K. U., Paus, R., & Tobin, D. J. (2005). Hair follicle pigmentation. The Journal of Investigative Dermatology, 124(1), 13-21.
Slominski A, et al. Hair Follicle Pigmentation. J Invest Dermatol. 2005;124(1):13-21. PubMed PMID: 15654948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair follicle pigmentation. AU - Slominski,Andrzej, AU - Wortsman,Jacobo, AU - Plonka,Przemyslaw M, AU - Schallreuter,Karin U, AU - Paus,Ralf, AU - Tobin,Desmond J, PY - 2005/1/19/pubmed PY - 2005/3/8/medline PY - 2005/1/19/entrez SP - 13 EP - 21 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 124 IS - 1 N2 - Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts. This activity is in turn regulated by an array of enzymes, structural and regulatory proteins, transporters, and receptors and their ligands, acting on the developmental stages, cellular, and hair follicle levels. FM is stringently coupled to the anagen stage of the hair cycle, being switched-off in catagen to remain absent through telogen. At the organ level FM is precisely coupled to the life cycle of melanocytes with changes in their compartmental distribution and accelerated melanoblast/melanocyte differentiation with enhanced secretory activity. The melanocyte compartments in the upper hair follicle also provides a reservoir for the repigmentation of epidermis and, for the cyclic formation of new anagen hair bulbs. Melanin synthesis and pigment transfer to bulb keratinocytes are dependent on the availability of melanin precursors, and regulation by signal transduction pathways intrinsic to skin and hair follicle, which are both receptor dependent and independent, act through auto-, para- or intracrine mechanisms and can be modified by hormonal signals. The important regulators are MC1 receptor its and adrenocorticotropic hormone, melanocyte stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endothelin receptors with their ligands. Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/15654948/Hair_follicle_pigmentation_ DB - PRIME DP - Unbound Medicine ER -