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Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives.
Br J Dermatol 2005; 152(1):82-6BJ

Abstract

BACKGROUND

The risk for lymphoma is increased in both dermatitis herpetiformis (DH) and in coeliac disease. The lymphoma most associated with coeliac disease is enteropathy-associated T-cell lymphoma.

OBJECTIVES

To study the occurrence and type of lymphoma in a large series of patients with DH and their first-degree relatives.

METHODS

The occurrence of lymphoma was studied in 1104 patients consecutively diagnosed with DH in two university hospitals during 1969-2001. A questionnaire was sent to 341 patients to examine the occurrence of lymphoma in their 1825 first-degree relatives. To analyse whether the DH patients with lymphoma had adhered to a gluten-free diet similarly to the patients without lymphoma, two age- and sex-matched patients with DH served as controls for each index case. Data on the gluten-free diet were collected from prospectively completed dietary forms and also from medical records.

RESULTS

Eleven (1%) patients contracted lymphoma 2-31 years after the diagnosis of DH. Eight had B-cell-type lymphoma, two enteropathy-associated T-cell lymphoma and one remained unclassified due to missing material. Three (0.2%) of the first-degree relatives contracted lymphoma, all B-cell type. The 11 DH patients with lymphoma had adhered to a gluten-free diet significantly less strictly than the DH controls without lymphoma.

CONCLUSIONS

The present study documents that patients with DH can have both B- and T-cell lymphoma. The DH patients with lymphoma had not adhered as strictly to the gluten-free diet as the control patients without lymphoma. The occurrence of lymphoma in the first-degree relatives was lower than in the patients with DH.

Authors+Show Affiliations

Department of Dermatology, Tampere University Hospital, PO Box 2000, FIN-33521 Tampere, Finland. Kaisa.Hervonen@pshp.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15656805

Citation

Hervonen, K, et al. "Lymphoma in Patients With Dermatitis Herpetiformis and Their First-degree Relatives." The British Journal of Dermatology, vol. 152, no. 1, 2005, pp. 82-6.
Hervonen K, Vornanen M, Kautiainen H, et al. Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives. Br J Dermatol. 2005;152(1):82-6.
Hervonen, K., Vornanen, M., Kautiainen, H., Collin, P., & Reunala, T. (2005). Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives. The British Journal of Dermatology, 152(1), pp. 82-6.
Hervonen K, et al. Lymphoma in Patients With Dermatitis Herpetiformis and Their First-degree Relatives. Br J Dermatol. 2005;152(1):82-6. PubMed PMID: 15656805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives. AU - Hervonen,K, AU - Vornanen,M, AU - Kautiainen,H, AU - Collin,P, AU - Reunala,T, PY - 2005/1/20/pubmed PY - 2005/4/15/medline PY - 2005/1/20/entrez SP - 82 EP - 6 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 152 IS - 1 N2 - BACKGROUND: The risk for lymphoma is increased in both dermatitis herpetiformis (DH) and in coeliac disease. The lymphoma most associated with coeliac disease is enteropathy-associated T-cell lymphoma. OBJECTIVES: To study the occurrence and type of lymphoma in a large series of patients with DH and their first-degree relatives. METHODS: The occurrence of lymphoma was studied in 1104 patients consecutively diagnosed with DH in two university hospitals during 1969-2001. A questionnaire was sent to 341 patients to examine the occurrence of lymphoma in their 1825 first-degree relatives. To analyse whether the DH patients with lymphoma had adhered to a gluten-free diet similarly to the patients without lymphoma, two age- and sex-matched patients with DH served as controls for each index case. Data on the gluten-free diet were collected from prospectively completed dietary forms and also from medical records. RESULTS: Eleven (1%) patients contracted lymphoma 2-31 years after the diagnosis of DH. Eight had B-cell-type lymphoma, two enteropathy-associated T-cell lymphoma and one remained unclassified due to missing material. Three (0.2%) of the first-degree relatives contracted lymphoma, all B-cell type. The 11 DH patients with lymphoma had adhered to a gluten-free diet significantly less strictly than the DH controls without lymphoma. CONCLUSIONS: The present study documents that patients with DH can have both B- and T-cell lymphoma. The DH patients with lymphoma had not adhered as strictly to the gluten-free diet as the control patients without lymphoma. The occurrence of lymphoma in the first-degree relatives was lower than in the patients with DH. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15656805/full_citation L2 - https://doi.org/10.1111/j.1365-2133.2005.06345.x DB - PRIME DP - Unbound Medicine ER -