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Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses.

Abstract

BACKGROUND

Recently, units have been developed that are capable of delivering large fluences of narrowband ultraviolet (UV) B selectively to cutaneous lesions within a reasonable time.

OBJECTIVES

To analyse the efficacy of a novel nonlaser 308-nm monochromatic excimer light (MEL) delivery system in various dermatoses usually treated by narrowband UVB phototherapy.

METHODS

Fifty-four patients with chronic and resistant localized dermatoses were enrolled in a prospective study: 17 with palmoplantar pustular psoriasis, seven with plaque-type psoriasis, four with nail psoriasis, eight with chronic atopic dermatitis of the hands, 10 with chronic nonatopic dermatitis of the hands and eight with alopecia areata. The 308-nm xenon chloride MEL delivery system (Excilite; DEKA, Florence, Italy) was used to produce an average incident dose rate of 50 mW cm(-2) at a tube-to-skin distance of 15 cm and with a maximum irradiating area of 512 cm2. The initial dose was based on multiples of a predetermined minimal erythema dose (MED), and subsequent doses were based on the response to treatment. Treatments were scheduled weekly for a maximum of 10 weeks. Clinical responses were evaluated using photographic documentation and (except for alopecia areata) clinical score.

RESULTS

The MED ranged from 250 to 350 mJ cm(-2) (mean +/- SD 318.2 +/- 28.4). MEL at 308 nm was the most effective for palmoplantar pustular psoriasis with a mean improvement of 79% after a mean of 5.3 treatments and a mean dose of 11.8 MED per treatment. Plaque-type psoriasis was significantly less sensitive to treatment and nail psoriasis demonstrated no benefit from treatment. Chronic palmar atopic dermatitis was cleared in two patients and the mean improvement was 54% as compared with 46% in patients with chronic nonatopic dermatitis of the hands. Four complete regrowths among the eight patients with alopecia were observed after a mean of 5.1 treatments. The percentages of improvement had significantly decreased at the 6-month visit, and only four patients (24%) with palmoplantar pustular psoriasis still demonstrated a significant improvement. Common side-effects included intense erythema and, more rarely, blisters, but these were well tolerated.

CONCLUSIONS

Our preliminary results confirm the efficacy of this novel 308-nm MEL delivery system, which appears to be effective and safe for palmoplantar pustular psoriasis. To a lesser extent, plaque-type psoriasis, chronic atopic and nonatopic dermatitis of the hands and alopecia may also benefit from this treatment.

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  • Authors+Show Affiliations

    ,

    Photodermatology Unit, Department of Dermatology, University Hospital, 2 Place Saint-Jacques, 25030 Besançon cedex, France. francois.aubin@ufc-chu.univ-fcomte.fr

    , , , , , ,

    Source

    The British journal of dermatology 152:1 2005 Jan pg 99-103

    MeSH

    Adult
    Alopecia Areata
    Chronic Disease
    Hand Dermatoses
    Humans
    Pilot Projects
    Prospective Studies
    Psoriasis
    Radiotherapy Dosage
    Skin Diseases
    Treatment Outcome
    Ultraviolet Therapy

    Pub Type(s)

    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    15656808

    Citation

    Aubin, F, et al. "Evaluation of a Novel 308-nm Monochromatic Excimer Light Delivery System in Dermatology: a Pilot Study in Different Chronic Localized Dermatoses." The British Journal of Dermatology, vol. 152, no. 1, 2005, pp. 99-103.
    Aubin F, Vigan M, Puzenat E, et al. Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses. Br J Dermatol. 2005;152(1):99-103.
    Aubin, F., Vigan, M., Puzenat, E., Blanc, D., Drobacheff, C., Deprez, P., ... Laurent, R. (2005). Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses. The British Journal of Dermatology, 152(1), pp. 99-103.
    Aubin F, et al. Evaluation of a Novel 308-nm Monochromatic Excimer Light Delivery System in Dermatology: a Pilot Study in Different Chronic Localized Dermatoses. Br J Dermatol. 2005;152(1):99-103. PubMed PMID: 15656808.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses. AU - Aubin,F, AU - Vigan,M, AU - Puzenat,E, AU - Blanc,D, AU - Drobacheff,C, AU - Deprez,P, AU - Humbert,P, AU - Laurent,R, PY - 2005/1/20/pubmed PY - 2005/4/15/medline PY - 2005/1/20/entrez SP - 99 EP - 103 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 152 IS - 1 N2 - BACKGROUND: Recently, units have been developed that are capable of delivering large fluences of narrowband ultraviolet (UV) B selectively to cutaneous lesions within a reasonable time. OBJECTIVES: To analyse the efficacy of a novel nonlaser 308-nm monochromatic excimer light (MEL) delivery system in various dermatoses usually treated by narrowband UVB phototherapy. METHODS: Fifty-four patients with chronic and resistant localized dermatoses were enrolled in a prospective study: 17 with palmoplantar pustular psoriasis, seven with plaque-type psoriasis, four with nail psoriasis, eight with chronic atopic dermatitis of the hands, 10 with chronic nonatopic dermatitis of the hands and eight with alopecia areata. The 308-nm xenon chloride MEL delivery system (Excilite; DEKA, Florence, Italy) was used to produce an average incident dose rate of 50 mW cm(-2) at a tube-to-skin distance of 15 cm and with a maximum irradiating area of 512 cm2. The initial dose was based on multiples of a predetermined minimal erythema dose (MED), and subsequent doses were based on the response to treatment. Treatments were scheduled weekly for a maximum of 10 weeks. Clinical responses were evaluated using photographic documentation and (except for alopecia areata) clinical score. RESULTS: The MED ranged from 250 to 350 mJ cm(-2) (mean +/- SD 318.2 +/- 28.4). MEL at 308 nm was the most effective for palmoplantar pustular psoriasis with a mean improvement of 79% after a mean of 5.3 treatments and a mean dose of 11.8 MED per treatment. Plaque-type psoriasis was significantly less sensitive to treatment and nail psoriasis demonstrated no benefit from treatment. Chronic palmar atopic dermatitis was cleared in two patients and the mean improvement was 54% as compared with 46% in patients with chronic nonatopic dermatitis of the hands. Four complete regrowths among the eight patients with alopecia were observed after a mean of 5.1 treatments. The percentages of improvement had significantly decreased at the 6-month visit, and only four patients (24%) with palmoplantar pustular psoriasis still demonstrated a significant improvement. Common side-effects included intense erythema and, more rarely, blisters, but these were well tolerated. CONCLUSIONS: Our preliminary results confirm the efficacy of this novel 308-nm MEL delivery system, which appears to be effective and safe for palmoplantar pustular psoriasis. To a lesser extent, plaque-type psoriasis, chronic atopic and nonatopic dermatitis of the hands and alopecia may also benefit from this treatment. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/15656808/Evaluation_of_a_novel_308_nm_monochromatic_excimer_light_delivery_system_in_dermatology:_a_pilot_study_in_different_chronic_localized_dermatoses_ L2 - https://doi.org/10.1111/j.1365-2133.2005.06320.x DB - PRIME DP - Unbound Medicine ER -