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Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients.
J Clin Endocrinol Metab. 2005 Jun; 90(6):3367-70.JC

Abstract

Prader-Willi syndrome (PWS) is the most common form of syndromic obesity associated with hyperphagia. Because ghrelin stimulates gastric motility in rodents, and PWS patients have 3- to 4-fold higher fasting plasma ghrelin concentrations than normal subjects, we hypothesized that hyperphagia associated with PWS may be partly explained by rapid gastric emptying due to the increased gastric motility caused by ghrelin. We determined gastric emptying times (GETs) and measured ghrelin levels in 11 PWS children and 11 age-, sex-, and body mass index-matched controls using a standard meal containing [(99m)Tc]diaminetriaminepentacetate. Median plasma ghrelin levels before (precibum) and after the GET study were higher in PWS patients than in controls (P = 0.004 and P = 0.001, respectively). Median percent gastric retentions at 90 min after the standard meal were 57.1% (range, 34.0-83.2%) in PWS patients and 40.2% (range, 27.2-60.2%) in controls (P = 0.03). In particular, precibum ghrelin concentrations were not significantly correlated with the rate of gastric emptying in PWS patients (P = 0.153; r = 0.461) or controls (P = 0.911; r = 0.048). Our results show that gastric emptying in PWS is reduced despite higher ghrelin levels, and that the voracious appetite associated with PWS is related to another mechanism.

Authors+Show Affiliations

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Il-Won Dong, Gang-Nam Gu, Seoul 135-710, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15657368

Citation

Choe, Yon Ho, et al. "Hyperghrelinemia Does Not Accelerate Gastric Emptying in Prader-Willi Syndrome Patients." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, 2005, pp. 3367-70.
Choe YH, Jin DK, Kim SE, et al. Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients. J Clin Endocrinol Metab. 2005;90(6):3367-70.
Choe, Y. H., Jin, D. K., Kim, S. E., Song, S. Y., Paik, K. H., Park, H. Y., Oh, Y. J., Kim, A. H., Kim, J. S., Kim, C. W., Chu, S. H., Kwon, E. K., & Lee, K. H. (2005). Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients. The Journal of Clinical Endocrinology and Metabolism, 90(6), 3367-70.
Choe YH, et al. Hyperghrelinemia Does Not Accelerate Gastric Emptying in Prader-Willi Syndrome Patients. J Clin Endocrinol Metab. 2005;90(6):3367-70. PubMed PMID: 15657368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients. AU - Choe,Yon Ho, AU - Jin,Dong-Kyu, AU - Kim,Sang Eun, AU - Song,Sang Yong, AU - Paik,Kyung Hoon, AU - Park,Hwa Young, AU - Oh,Yoo Joung, AU - Kim,An Hee, AU - Kim,Jung Sim, AU - Kim,Chi Wha, AU - Chu,Su-Hyun, AU - Kwon,Eun Kyung, AU - Lee,Kyung Han, Y1 - 2005/01/18/ PY - 2005/1/20/pubmed PY - 2005/7/6/medline PY - 2005/1/20/entrez SP - 3367 EP - 70 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 90 IS - 6 N2 - Prader-Willi syndrome (PWS) is the most common form of syndromic obesity associated with hyperphagia. Because ghrelin stimulates gastric motility in rodents, and PWS patients have 3- to 4-fold higher fasting plasma ghrelin concentrations than normal subjects, we hypothesized that hyperphagia associated with PWS may be partly explained by rapid gastric emptying due to the increased gastric motility caused by ghrelin. We determined gastric emptying times (GETs) and measured ghrelin levels in 11 PWS children and 11 age-, sex-, and body mass index-matched controls using a standard meal containing [(99m)Tc]diaminetriaminepentacetate. Median plasma ghrelin levels before (precibum) and after the GET study were higher in PWS patients than in controls (P = 0.004 and P = 0.001, respectively). Median percent gastric retentions at 90 min after the standard meal were 57.1% (range, 34.0-83.2%) in PWS patients and 40.2% (range, 27.2-60.2%) in controls (P = 0.03). In particular, precibum ghrelin concentrations were not significantly correlated with the rate of gastric emptying in PWS patients (P = 0.153; r = 0.461) or controls (P = 0.911; r = 0.048). Our results show that gastric emptying in PWS is reduced despite higher ghrelin levels, and that the voracious appetite associated with PWS is related to another mechanism. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15657368/Hyperghrelinemia_does_not_accelerate_gastric_emptying_in_Prader_Willi_syndrome_patients_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2004-1651 DB - PRIME DP - Unbound Medicine ER -