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Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.
Eur J Hum Genet. 2005 Apr; 13(4):445-51.EJ

Abstract

The objective of this paper was to identify the single nucleotide polymorphisms (SNPs) that show unshared effects on plasma triglyceride (TG) levels and to investigate whether these SNPs show statistically independent effects on plasma TG levels. In total, 59 polymorphisms in 20 genes involved in lipid metabolism were investigated. Polymorphisms were selected for a multivariate ANOVA model if they showed an univariate association with TG (after adjustment for HDL-C and LDL-C) in more than 50% of bootstrap samples that were made from the original data. The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). The gene variants APOA1 G(-75)A (P=0.04) and LPL Asn291Ser (P=0.03) were significantly associated with plasma TG levels in this multivariate analysis. The eight polymorphisms explained 8.9% of the variation in plasma TG levels. In conclusion, this study showed statistically independent effects of gene variants in the APOA1 and LPL genes on fasting plasma levels of TG. Nevertheless, only a small part of variation in TG levels could be explained by the polymorphisms.

Authors+Show Affiliations

Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands. o.w.souverein@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15657615

Citation

Souverein, Olga W., et al. "Polymorphisms in APOA1 and LPL Genes Are Statistically Independently Associated With Fasting TG in Men With CAD." European Journal of Human Genetics : EJHG, vol. 13, no. 4, 2005, pp. 445-51.
Souverein OW, Jukema JW, Boekholdt SM, et al. Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. Eur J Hum Genet. 2005;13(4):445-51.
Souverein, O. W., Jukema, J. W., Boekholdt, S. M., Zwinderman, A. H., & Tanck, M. W. (2005). Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. European Journal of Human Genetics : EJHG, 13(4), 445-51.
Souverein OW, et al. Polymorphisms in APOA1 and LPL Genes Are Statistically Independently Associated With Fasting TG in Men With CAD. Eur J Hum Genet. 2005;13(4):445-51. PubMed PMID: 15657615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. AU - Souverein,Olga W, AU - Jukema,J Wouter, AU - Boekholdt,S Matthijs, AU - Zwinderman,Aeilko H, AU - Tanck,Michael W T, PY - 2005/1/20/pubmed PY - 2005/7/22/medline PY - 2005/1/20/entrez SP - 445 EP - 51 JF - European journal of human genetics : EJHG JO - Eur J Hum Genet VL - 13 IS - 4 N2 - The objective of this paper was to identify the single nucleotide polymorphisms (SNPs) that show unshared effects on plasma triglyceride (TG) levels and to investigate whether these SNPs show statistically independent effects on plasma TG levels. In total, 59 polymorphisms in 20 genes involved in lipid metabolism were investigated. Polymorphisms were selected for a multivariate ANOVA model if they showed an univariate association with TG (after adjustment for HDL-C and LDL-C) in more than 50% of bootstrap samples that were made from the original data. The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). The gene variants APOA1 G(-75)A (P=0.04) and LPL Asn291Ser (P=0.03) were significantly associated with plasma TG levels in this multivariate analysis. The eight polymorphisms explained 8.9% of the variation in plasma TG levels. In conclusion, this study showed statistically independent effects of gene variants in the APOA1 and LPL genes on fasting plasma levels of TG. Nevertheless, only a small part of variation in TG levels could be explained by the polymorphisms. SN - 1018-4813 UR - https://www.unboundmedicine.com/medline/citation/15657615/Polymorphisms_in_APOA1_and_LPL_genes_are_statistically_independently_associated_with_fasting_TG_in_men_with_CAD_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -