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Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project.
Aust N Z J Psychiatry. 2005 Jan-Feb; 39(1-2):36-43.AN

Abstract

OBJECTIVE

To examine the clinical profile, treatment and social functioning of a community-based sample of young people presenting with their first episode of psychosis.

METHODS

Over a 2-year period, young people with their first episode of psychosis referred to early intervention services in two area mental health services in western Sydney were assessed with a battery of clinical, neuropsychological, psychophysiological and neuroanatomical measures. This paper reports the clinical results of the baseline section of the study.

RESULTS

Of the 224 referrals to the project, 94 subjects meet inclusion criteria and agreed to take part. Subjects were divided into three diagnostic groups--'Schizophrenia', 'Mood Disorders' and 'Mixed Psychosis', the latter principally comprised of substance induced psychotic disorders. Subjects from the 'Schizophrenia' group differed significantly from the other two groups in that they had higher levels of negative symptoms and general psychopathology, and were less likely to be employed or engaged in study. They had poorer overall social functioning. Subjects with 'Mixed Psychosis' were similar to those from the 'Schizophrenia' group in that they were older and male, but they did not have the same burden of negative symptoms as the 'Schizophrenia' group. The 'Mood Disorders' group was younger, female and had overall a higher level of psychosocial functioning than the other two groups. Subjects from the 'Mood Disorders' group were more likely to be managed with mood stabilisers and multiple drug therapies. The use of atypical antipsychotic medication was almost universal.

CONCLUSIONS

Even shortly after the time of presentation to mental health services young people with a schizophrenia spectrum diagnosis have a heavier burden of symptoms and are significantly more impaired by them than young people with other psychotic illnesses. This and their symptom profile differentiated them from young people with other psychotic disorders.

Authors+Show Affiliations

University of Sydney, Westmead Hospital, New South Wales, Australia. aharris1@mail.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15660704

Citation

Harris, Anthony, et al. "Clinical Profiles, Scope and General Findings of the Western Sydney First Episode Psychosis Project." The Australian and New Zealand Journal of Psychiatry, vol. 39, no. 1-2, 2005, pp. 36-43.
Harris A, Brennan J, Anderson J, et al. Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. Aust N Z J Psychiatry. 2005;39(1-2):36-43.
Harris, A., Brennan, J., Anderson, J., Taylor, A., Sanbrook, M., Fitzgerald, D., Lucas, S., Redoblado-Hodge, A., Gomes, L., & Gordon, E. (2005). Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. The Australian and New Zealand Journal of Psychiatry, 39(1-2), 36-43.
Harris A, et al. Clinical Profiles, Scope and General Findings of the Western Sydney First Episode Psychosis Project. Aust N Z J Psychiatry. 2005 Jan-Feb;39(1-2):36-43. PubMed PMID: 15660704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. AU - Harris,Anthony, AU - Brennan,John, AU - Anderson,Josephine, AU - Taylor,Anne, AU - Sanbrook,Mark, AU - Fitzgerald,Dianne, AU - Lucas,Sara, AU - Redoblado-Hodge,Antoinette, AU - Gomes,Lavier, AU - Gordon,Evian, PY - 2005/1/22/pubmed PY - 2005/6/29/medline PY - 2005/1/22/entrez SP - 36 EP - 43 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 39 IS - 1-2 N2 - OBJECTIVE: To examine the clinical profile, treatment and social functioning of a community-based sample of young people presenting with their first episode of psychosis. METHODS: Over a 2-year period, young people with their first episode of psychosis referred to early intervention services in two area mental health services in western Sydney were assessed with a battery of clinical, neuropsychological, psychophysiological and neuroanatomical measures. This paper reports the clinical results of the baseline section of the study. RESULTS: Of the 224 referrals to the project, 94 subjects meet inclusion criteria and agreed to take part. Subjects were divided into three diagnostic groups--'Schizophrenia', 'Mood Disorders' and 'Mixed Psychosis', the latter principally comprised of substance induced psychotic disorders. Subjects from the 'Schizophrenia' group differed significantly from the other two groups in that they had higher levels of negative symptoms and general psychopathology, and were less likely to be employed or engaged in study. They had poorer overall social functioning. Subjects with 'Mixed Psychosis' were similar to those from the 'Schizophrenia' group in that they were older and male, but they did not have the same burden of negative symptoms as the 'Schizophrenia' group. The 'Mood Disorders' group was younger, female and had overall a higher level of psychosocial functioning than the other two groups. Subjects from the 'Mood Disorders' group were more likely to be managed with mood stabilisers and multiple drug therapies. The use of atypical antipsychotic medication was almost universal. CONCLUSIONS: Even shortly after the time of presentation to mental health services young people with a schizophrenia spectrum diagnosis have a heavier burden of symptoms and are significantly more impaired by them than young people with other psychotic illnesses. This and their symptom profile differentiated them from young people with other psychotic disorders. SN - 0004-8674 UR - https://www.unboundmedicine.com/medline/citation/15660704/Clinical_profiles_scope_and_general_findings_of_the_Western_Sydney_First_Episode_Psychosis_Project_ L2 - https://journals.sagepub.com/doi/10.1111/j.1440-1614.2005.01517.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -