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Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study.
Diabet Med 2005; 22(2):200-6DM

Abstract

AIMS

To investigate perinatal risk factors for childhood Type 1 diabetes in a UK population cohort.

METHODS

Perinatal data have been routinely recorded in Northern Ireland for all births in the period 1971-86 (n = 447 663). Diabetes status at the age of 15 years was ascertained in this cohort by identifying 991 children from 1079 registered with Type 1 diabetes diagnosed from 1971 to 2001 and date of birth in the period 1971-86.

RESULTS

Increased Type 1 diabetes risk was associated with higher maternal age, paternal age, birth weight and birth weight for gestational and lower gestational age. After adjustment for maternal age, the association between Type 1 diabetes and paternal age remained significant [relative risk (RR) = 1.52 (1.10, 2.09) comparing father's age 35 years or more to less than 25 years] but not vice versa [RR = 1.11 (0.80, 1.54) comparing mother's age 35 years or more to less than 25 years]. Increased birth order was associated with a significant decrease in the risk of Type 1 diabetes [adjusted RR = 0.75 (0.62, 0.90) comparing birth order three or more with firstborn], but this only became apparent when adjustment was made for maternal age. Furthermore this association with birth order was significant only for diabetes diagnosed under the age of 5 years.

CONCLUSIONS

Our analysis demonstrates, for the first time in a UK regional cohort setting, that maternal age and paternal age at delivery, birth order, birth weight and gestational age are significantly associated with Type 1 diabetes risk.

Authors+Show Affiliations

Department of Epidemiology & Public Health, The Queen's University of Belfast, Belfast, UK. c.cardwell@qub.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15660739

Citation

Cardwell, C R., et al. "Parental Age at Delivery, Birth Order, Birth Weight and Gestational Age Are Associated With the Risk of Childhood Type 1 Diabetes: a UK Regional Retrospective Cohort Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 2, 2005, pp. 200-6.
Cardwell CR, Carson DJ, Patterson CC. Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study. Diabet Med. 2005;22(2):200-6.
Cardwell, C. R., Carson, D. J., & Patterson, C. C. (2005). Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study. Diabetic Medicine : a Journal of the British Diabetic Association, 22(2), pp. 200-6.
Cardwell CR, Carson DJ, Patterson CC. Parental Age at Delivery, Birth Order, Birth Weight and Gestational Age Are Associated With the Risk of Childhood Type 1 Diabetes: a UK Regional Retrospective Cohort Study. Diabet Med. 2005;22(2):200-6. PubMed PMID: 15660739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study. AU - Cardwell,C R, AU - Carson,D J, AU - Patterson,C C, PY - 2005/1/22/pubmed PY - 2005/4/20/medline PY - 2005/1/22/entrez SP - 200 EP - 6 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 22 IS - 2 N2 - AIMS: To investigate perinatal risk factors for childhood Type 1 diabetes in a UK population cohort. METHODS: Perinatal data have been routinely recorded in Northern Ireland for all births in the period 1971-86 (n = 447 663). Diabetes status at the age of 15 years was ascertained in this cohort by identifying 991 children from 1079 registered with Type 1 diabetes diagnosed from 1971 to 2001 and date of birth in the period 1971-86. RESULTS: Increased Type 1 diabetes risk was associated with higher maternal age, paternal age, birth weight and birth weight for gestational and lower gestational age. After adjustment for maternal age, the association between Type 1 diabetes and paternal age remained significant [relative risk (RR) = 1.52 (1.10, 2.09) comparing father's age 35 years or more to less than 25 years] but not vice versa [RR = 1.11 (0.80, 1.54) comparing mother's age 35 years or more to less than 25 years]. Increased birth order was associated with a significant decrease in the risk of Type 1 diabetes [adjusted RR = 0.75 (0.62, 0.90) comparing birth order three or more with firstborn], but this only became apparent when adjustment was made for maternal age. Furthermore this association with birth order was significant only for diabetes diagnosed under the age of 5 years. CONCLUSIONS: Our analysis demonstrates, for the first time in a UK regional cohort setting, that maternal age and paternal age at delivery, birth order, birth weight and gestational age are significantly associated with Type 1 diabetes risk. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15660739/Parental_age_at_delivery_birth_order_birth_weight_and_gestational_age_are_associated_with_the_risk_of_childhood_Type_1_diabetes:_a_UK_regional_retrospective_cohort_study_ L2 - https://doi.org/10.1111/j.1464-5491.2005.01369.x DB - PRIME DP - Unbound Medicine ER -