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[Clinical validity of anti-thyroperoxidase antibody and anti-thyroglobulin antibody].

Abstract

OBJECTIVE

To evaluate the clinical validity of anti-thyroperoxidase antibody (anti-TPOAb) and anti-thyroglobulin antibody (anti-TgAb).

METHOD

Serum levels of anti-TPOAb and anti-TgAb were assayed using chemiluminescence immunoassay in 434 subjects, including 51 patients with Hashimoto's thyroiditis, 58 with Graves' disease, 68 with nodular goiter, 56 with thyroid adenoma and carcinoma, 56 with subacute thyroiditis, 65 with euthyroid non-thyroid endocrine disease, 35 with euthyroid non-thyroid autoimmune diseases, and 45 euthyroid controls.

RESULTS

The highest level and most positive results of serum anti-TgAb and anti-TPOAb were observed in patients with Hashimoto's thyroiditis (median 373 and 6 974 U/ml, positive rate 84.3% and 86.3%), followed by patients with Graves' disease (median 84 and 1 369 U/ml, positive rate 44.8% and 72.4%). Serum anti-TgAb and anti-TPOAb were also more common in patients with subacute thyroiditis and other autoimmune diseases than in the controls.

CONCLUSION

The assay of serum anti-TPOAb and anti-TgAb by chemiluminescence immunoassy are useful in the differential diagnosis of autoimmune thyroid disease.

Authors+Show Affiliations

Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. lianlanx@public.bta.ner.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

chi

PubMed ID

15663231

Citation

Lian, Xiao-Lan, et al. "[Clinical Validity of Anti-thyroperoxidase Antibody and Anti-thyroglobulin Antibody]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 6, 2004, pp. 677-81.
Lian XL, Bai Y, Sun ML, et al. [Clinical validity of anti-thyroperoxidase antibody and anti-thyroglobulin antibody]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(6):677-81.
Lian, X. L., Bai, Y., Sun, M. L., Guo, Z. S., & Dai, W. X. (2004). [Clinical validity of anti-thyroperoxidase antibody and anti-thyroglobulin antibody]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(6), pp. 677-81.
Lian XL, et al. [Clinical Validity of Anti-thyroperoxidase Antibody and Anti-thyroglobulin Antibody]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(6):677-81. PubMed PMID: 15663231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical validity of anti-thyroperoxidase antibody and anti-thyroglobulin antibody]. AU - Lian,Xiao-Lan, AU - Bai,Yao, AU - Sun,Mei-Li, AU - Guo,Zhi-Sheng, AU - Dai,Wei-Xin, PY - 2005/1/25/pubmed PY - 2006/5/24/medline PY - 2005/1/25/entrez SP - 677 EP - 81 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 6 N2 - OBJECTIVE: To evaluate the clinical validity of anti-thyroperoxidase antibody (anti-TPOAb) and anti-thyroglobulin antibody (anti-TgAb). METHOD: Serum levels of anti-TPOAb and anti-TgAb were assayed using chemiluminescence immunoassay in 434 subjects, including 51 patients with Hashimoto's thyroiditis, 58 with Graves' disease, 68 with nodular goiter, 56 with thyroid adenoma and carcinoma, 56 with subacute thyroiditis, 65 with euthyroid non-thyroid endocrine disease, 35 with euthyroid non-thyroid autoimmune diseases, and 45 euthyroid controls. RESULTS: The highest level and most positive results of serum anti-TgAb and anti-TPOAb were observed in patients with Hashimoto's thyroiditis (median 373 and 6 974 U/ml, positive rate 84.3% and 86.3%), followed by patients with Graves' disease (median 84 and 1 369 U/ml, positive rate 44.8% and 72.4%). Serum anti-TgAb and anti-TPOAb were also more common in patients with subacute thyroiditis and other autoimmune diseases than in the controls. CONCLUSION: The assay of serum anti-TPOAb and anti-TgAb by chemiluminescence immunoassy are useful in the differential diagnosis of autoimmune thyroid disease. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15663231/[Clinical_validity_of_anti_thyroperoxidase_antibody_and_anti_thyroglobulin_antibody]_ DB - PRIME DP - Unbound Medicine ER -