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Association between apolipoprotein E polymorphism and Alzheimer disease in Tehran, Iran.

Abstract

Epsilon 4 allele of apolipoprotein E (APOE-epsilon4) is a major risk factor for Alzheimer's disease (AD). The association of APOE allele frequencies with AD remains unknown in developing countries. We examined the frequency of APOE alleles in 105 patients with AD and 129 cognitively normal subjects of similar age and sex (control group), in Tehran, Iran. The APOE-epsilon4 allele frequency was significantly higher in the AD subjects than in the control group (21% versus 6.2%, p < 0.001). In addition, the OR for APOE-epsilon4 heterozygous and homozygous subjects were 3.2 (p = 0.001) and 12.75 (p = 0.01), respectively. The OR was not uniform across age groups. The AD subjects carrying one or two APOE-epsilon4 allele showed earlier age-at-onset (p < 0.001). These data suggest that the APOE-epsilon4 allele increase the risk for AD in Tehran population in a dose and age-dependent manner. Although the APOE-epsilon2 allele frequency was lower in the AD subjects than in the control group (0.95% versus 2.7%, p = 0.15), APOE-epsilon2 was not associated with the onset of AD in Tehran's population. The OR for epsilon2 allele in AD subjects was 0.34 (p = 0.21). The genotype frequencies for epsilon3, epsilon4, and epsilon2 alleles in control subjects were 91.2, 6.1, and 2.7%, respectively. These values were similar to that reported for Turkish, Greece, Japanese, Spanish, and Moroccan populations, but they were significantly different from the reported values for the other ethnic populations. This observation emphasizes the importance of geographical location and ethnical background of the subjects in the study of APOE genotypes and their association with AD.

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  • Authors+Show Affiliations

    ,

    Department of Medical Biochemistry, University of Tehran, Tehran, Iran. vaisiraygani@yahoo.com

    , , , , ,

    Source

    Neuroscience letters 375:1 2005 Feb 25 pg 1-6

    MeSH

    Age of Onset
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Analysis of Variance
    Apolipoprotein E4
    Apolipoproteins E
    Case-Control Studies
    Chi-Square Distribution
    Continental Population Groups
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Genotype
    Humans
    Iran
    Male
    Middle Aged
    Polymerase Chain Reaction
    Polymorphism, Genetic
    Sex Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15664112

    Citation

    Raygani, Asad Vaisi, et al. "Association Between Apolipoprotein E Polymorphism and Alzheimer Disease in Tehran, Iran." Neuroscience Letters, vol. 375, no. 1, 2005, pp. 1-6.
    Raygani AV, Zahrai M, Raygani AV, et al. Association between apolipoprotein E polymorphism and Alzheimer disease in Tehran, Iran. Neurosci Lett. 2005;375(1):1-6.
    Raygani, A. V., Zahrai, M., Raygani, A. V., Doosti, M., Javadi, E., Rezaei, M., & Pourmotabbed, T. (2005). Association between apolipoprotein E polymorphism and Alzheimer disease in Tehran, Iran. Neuroscience Letters, 375(1), pp. 1-6.
    Raygani AV, et al. Association Between Apolipoprotein E Polymorphism and Alzheimer Disease in Tehran, Iran. Neurosci Lett. 2005 Feb 25;375(1):1-6. PubMed PMID: 15664112.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between apolipoprotein E polymorphism and Alzheimer disease in Tehran, Iran. AU - Raygani,Asad Vaisi, AU - Zahrai,Mahine, AU - Raygani,Akbar Vaisi, AU - Doosti,Mahmood, AU - Javadi,Ebrahim, AU - Rezaei,Mansour, AU - Pourmotabbed,Tayebeh, Y1 - 2004/11/26/ PY - 2004/06/19/received PY - 2004/10/13/revised PY - 2004/10/21/accepted PY - 2005/1/25/pubmed PY - 2005/4/19/medline PY - 2005/1/25/entrez SP - 1 EP - 6 JF - Neuroscience letters JO - Neurosci. Lett. VL - 375 IS - 1 N2 - Epsilon 4 allele of apolipoprotein E (APOE-epsilon4) is a major risk factor for Alzheimer's disease (AD). The association of APOE allele frequencies with AD remains unknown in developing countries. We examined the frequency of APOE alleles in 105 patients with AD and 129 cognitively normal subjects of similar age and sex (control group), in Tehran, Iran. The APOE-epsilon4 allele frequency was significantly higher in the AD subjects than in the control group (21% versus 6.2%, p < 0.001). In addition, the OR for APOE-epsilon4 heterozygous and homozygous subjects were 3.2 (p = 0.001) and 12.75 (p = 0.01), respectively. The OR was not uniform across age groups. The AD subjects carrying one or two APOE-epsilon4 allele showed earlier age-at-onset (p < 0.001). These data suggest that the APOE-epsilon4 allele increase the risk for AD in Tehran population in a dose and age-dependent manner. Although the APOE-epsilon2 allele frequency was lower in the AD subjects than in the control group (0.95% versus 2.7%, p = 0.15), APOE-epsilon2 was not associated with the onset of AD in Tehran's population. The OR for epsilon2 allele in AD subjects was 0.34 (p = 0.21). The genotype frequencies for epsilon3, epsilon4, and epsilon2 alleles in control subjects were 91.2, 6.1, and 2.7%, respectively. These values were similar to that reported for Turkish, Greece, Japanese, Spanish, and Moroccan populations, but they were significantly different from the reported values for the other ethnic populations. This observation emphasizes the importance of geographical location and ethnical background of the subjects in the study of APOE genotypes and their association with AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15664112/Association_between_apolipoprotein_E_polymorphism_and_Alzheimer_disease_in_Tehran_Iran_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(04)01374-6 DB - PRIME DP - Unbound Medicine ER -