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Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression.

Abstract

Converging evidence suggests that omega-3 polyunsaturated fatty acids have aetiological importance in depression. To determine the effect of adding fish oil to existing therapy in participants who were being treated for depression in a community setting, 77 participants were randomly assigned to receive 8 g of either fish or olive oil per day in addition to their existing therapy. Fifty-nine (77%) participants completed 12 weeks of treatment. Dietary, biochemical and lifestyle factors were measured throughout the study. Mood was assessed using the Short Form Hamilton Depression Rating Scale (HDRS-SF) and the Beck Depression Inventory II. Sample size calculations were based on the HDRS-SF. Intention-to-treat and per protocol analyses were carried out using residual maximum likelihood. There was no evidence that fish oil improved mood when compared to the placebo oil, despite an increase in circulating omega-3 polyunsaturated fatty acids. However, mood improved significantly in both groups within the first 2 weeks of the study (P<0.001) and this improvement was sustained throughout. In conclusion, fish oil was no more effective than the control as an add-on therapy for depression in this setting.

Authors+Show Affiliations

New Zealand Institute for Crop & Food Research, Private Bag 4704, Christchurch, New Zealand. silversk@crop.cri.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15664306

Citation

Silvers, Karen M., et al. "Randomised Double-blind Placebo-controlled Trial of Fish Oil in the Treatment of Depression." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 72, no. 3, 2005, pp. 211-8.
Silvers KM, Woolley CC, Hamilton FC, et al. Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 2005;72(3):211-8.
Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M., & Watson, R. A. (2005). Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 72(3), 211-8.
Silvers KM, et al. Randomised Double-blind Placebo-controlled Trial of Fish Oil in the Treatment of Depression. Prostaglandins Leukot Essent Fatty Acids. 2005;72(3):211-8. PubMed PMID: 15664306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. AU - Silvers,Karen M, AU - Woolley,Cheryl C, AU - Hamilton,Frances C, AU - Watts,Peter M, AU - Watson,Rosemary A, PY - 2004/07/23/received PY - 2004/11/21/accepted PY - 2005/1/25/pubmed PY - 2005/12/13/medline PY - 2005/1/25/entrez SP - 211 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 72 IS - 3 N2 - Converging evidence suggests that omega-3 polyunsaturated fatty acids have aetiological importance in depression. To determine the effect of adding fish oil to existing therapy in participants who were being treated for depression in a community setting, 77 participants were randomly assigned to receive 8 g of either fish or olive oil per day in addition to their existing therapy. Fifty-nine (77%) participants completed 12 weeks of treatment. Dietary, biochemical and lifestyle factors were measured throughout the study. Mood was assessed using the Short Form Hamilton Depression Rating Scale (HDRS-SF) and the Beck Depression Inventory II. Sample size calculations were based on the HDRS-SF. Intention-to-treat and per protocol analyses were carried out using residual maximum likelihood. There was no evidence that fish oil improved mood when compared to the placebo oil, despite an increase in circulating omega-3 polyunsaturated fatty acids. However, mood improved significantly in both groups within the first 2 weeks of the study (P<0.001) and this improvement was sustained throughout. In conclusion, fish oil was no more effective than the control as an add-on therapy for depression in this setting. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/15664306/Randomised_double_blind_placebo_controlled_trial_of_fish_oil_in_the_treatment_of_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(04)00190-5 DB - PRIME DP - Unbound Medicine ER -