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Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode.
J Pharm Biomed Anal. 2005 Feb 07; 37(1):195-8.JP

Abstract

The electrochemical oxidation of bromocriptine at glassy carbon electrode has been carried out in Britton-Robinson (B-R) buffer solutions in the pH range 2.0-11.0 employing cyclic, linear sweep and differential pulse voltammetry (DPV). Bromocriptine showed one well-defined oxidation peak accompanied by a smaller one. The oxidation process was found irreversible. For analytical purposes, the well-resolved diffusion controlled voltammetric peak at pH 5 was critically investigated. The linear relationship between peak current height and bromocriptine concentration allowed the differential pulse voltammetric determination of the drug over a wide concentration range, from 0.04 to 5.00 microg ml(-1) with a detection limit of 0.01 microg ml(-1). A relative standard deviation of 1.44% at 0.1 microg ml(-1) level was obtained. The proposed DPV method was successfully applied for the individual tablet assay to verify the uniformity content of bromocriptine in commercial tablets.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15664762

Citation

Radi, A, et al. "Differential Pulse Voltammetric Determination of the Dopaminergic Agonist Bromocriptine at Glassy Carbon Electrode." Journal of Pharmaceutical and Biomedical Analysis, vol. 37, no. 1, 2005, pp. 195-8.
Radi A, El-Shahawi MS, Elmogy T. Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode. J Pharm Biomed Anal. 2005;37(1):195-8.
Radi, A., El-Shahawi, M. S., & Elmogy, T. (2005). Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode. Journal of Pharmaceutical and Biomedical Analysis, 37(1), 195-8.
Radi A, El-Shahawi MS, Elmogy T. Differential Pulse Voltammetric Determination of the Dopaminergic Agonist Bromocriptine at Glassy Carbon Electrode. J Pharm Biomed Anal. 2005 Feb 7;37(1):195-8. PubMed PMID: 15664762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode. AU - Radi,A, AU - El-Shahawi,M S, AU - Elmogy,T, PY - 2004/05/02/received PY - 2004/10/06/revised PY - 2004/10/10/accepted PY - 2005/1/25/pubmed PY - 2005/6/18/medline PY - 2005/1/25/entrez SP - 195 EP - 8 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 37 IS - 1 N2 - The electrochemical oxidation of bromocriptine at glassy carbon electrode has been carried out in Britton-Robinson (B-R) buffer solutions in the pH range 2.0-11.0 employing cyclic, linear sweep and differential pulse voltammetry (DPV). Bromocriptine showed one well-defined oxidation peak accompanied by a smaller one. The oxidation process was found irreversible. For analytical purposes, the well-resolved diffusion controlled voltammetric peak at pH 5 was critically investigated. The linear relationship between peak current height and bromocriptine concentration allowed the differential pulse voltammetric determination of the drug over a wide concentration range, from 0.04 to 5.00 microg ml(-1) with a detection limit of 0.01 microg ml(-1). A relative standard deviation of 1.44% at 0.1 microg ml(-1) level was obtained. The proposed DPV method was successfully applied for the individual tablet assay to verify the uniformity content of bromocriptine in commercial tablets. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/15664762/Differential_pulse_voltammetric_determination_of_the_dopaminergic_agonist_bromocriptine_at_glassy_carbon_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(04)00518-7 DB - PRIME DP - Unbound Medicine ER -