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Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis.
Nephrol Dial Transplant. 2005 Mar; 20(3):578-84.ND

Abstract

BACKGROUND

Most patients on haemodialysis (HD) have to maintain a fluid-restricted diet to prevent a high interdialytic weight gain (IWG). The prevalence of xerostomia (the feeling of a dry mouth) is higher in HD patients than in controls. Recently, we demonstrated that xerostomia and thirst were positively correlated with IWG in HD patients. Thus, this may play a role as a stimulus for fluid intake between dialysis sessions. The aim of the present study was to investigate the effect of chewing gum or a saliva substitute on xerostomia, thirst and IWG.

METHODS

This study was a randomized two-treatment crossover design with repeated measures. After the use of chewing gum or saliva substitute for 2 weeks, a wash-out period of 2 weeks was introduced and hereafter the other regimen was carried out. Xerostomia and thirst were assessed by validated questionnaires as xerostomia inventory (XI) and dialysis thirst inventory (DTI), at baseline and after each treatment period, as were IWG and salivary flow rates.

RESULTS

Sixty-five HD patients (42 men, 54.6+/-14.1 years; 23 women, 54.7+/-16.3 years) participated in this study. Chewing gum decreased XI from 29.9+/-9.5 to 28.1+/-9.1 (P<0.05). Chewing gum as well as a saliva substitute reduced DTI significantly (P<0.05), but no differences occurred for the average IWG or salivary flow rates.

CONCLUSIONS

The use of chewing gum and, to a lesser extent, a saliva substitute may alleviate thirst and xerostomia in some HD patients.

Authors+Show Affiliations

Department of Oral Biochemistry, Academic Center for Dentistry, Amsterdam, The Netherlands. c.bots@vumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15665029

Citation

Bots, Casper P., et al. "Chewing Gum and a Saliva Substitute Alleviate Thirst and Xerostomia in Patients On Haemodialysis." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 20, no. 3, 2005, pp. 578-84.
Bots CP, Brand HS, Veerman EC, et al. Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. Nephrol Dial Transplant. 2005;20(3):578-84.
Bots, C. P., Brand, H. S., Veerman, E. C., Korevaar, J. C., Valentijn-Benz, M., Bezemer, P. D., Valentijn, R. M., Vos, P. F., Bijlsma, J. A., ter Wee, P. M., Van Amerongen, B. M., & Nieuw Amerongen, A. V. (2005). Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 20(3), 578-84.
Bots CP, et al. Chewing Gum and a Saliva Substitute Alleviate Thirst and Xerostomia in Patients On Haemodialysis. Nephrol Dial Transplant. 2005;20(3):578-84. PubMed PMID: 15665029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. AU - Bots,Casper P, AU - Brand,Henk S, AU - Veerman,Enno C I, AU - Korevaar,Johanna C, AU - Valentijn-Benz,Marianne, AU - Bezemer,Pieter D, AU - Valentijn,Robert M, AU - Vos,Pieter F, AU - Bijlsma,Joost A, AU - ter Wee,Piet M, AU - Van Amerongen,Barbara M, AU - Nieuw Amerongen,Arie V, Y1 - 2005/01/21/ PY - 2005/1/25/pubmed PY - 2005/5/17/medline PY - 2005/1/25/entrez SP - 578 EP - 84 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 20 IS - 3 N2 - BACKGROUND: Most patients on haemodialysis (HD) have to maintain a fluid-restricted diet to prevent a high interdialytic weight gain (IWG). The prevalence of xerostomia (the feeling of a dry mouth) is higher in HD patients than in controls. Recently, we demonstrated that xerostomia and thirst were positively correlated with IWG in HD patients. Thus, this may play a role as a stimulus for fluid intake between dialysis sessions. The aim of the present study was to investigate the effect of chewing gum or a saliva substitute on xerostomia, thirst and IWG. METHODS: This study was a randomized two-treatment crossover design with repeated measures. After the use of chewing gum or saliva substitute for 2 weeks, a wash-out period of 2 weeks was introduced and hereafter the other regimen was carried out. Xerostomia and thirst were assessed by validated questionnaires as xerostomia inventory (XI) and dialysis thirst inventory (DTI), at baseline and after each treatment period, as were IWG and salivary flow rates. RESULTS: Sixty-five HD patients (42 men, 54.6+/-14.1 years; 23 women, 54.7+/-16.3 years) participated in this study. Chewing gum decreased XI from 29.9+/-9.5 to 28.1+/-9.1 (P<0.05). Chewing gum as well as a saliva substitute reduced DTI significantly (P<0.05), but no differences occurred for the average IWG or salivary flow rates. CONCLUSIONS: The use of chewing gum and, to a lesser extent, a saliva substitute may alleviate thirst and xerostomia in some HD patients. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/15665029/Chewing_gum_and_a_saliva_substitute_alleviate_thirst_and_xerostomia_in_patients_on_haemodialysis_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfh675 DB - PRIME DP - Unbound Medicine ER -