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HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls.
Dis Markers. 2004; 20(6):309-12.DM

Abstract

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P=0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.

Links

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Authors+Show Affiliations

Oguz FS
Istanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, Turkey. oguzsf@usa.net
Ocal L
No affiliation info available
Diler AS
No affiliation info available
Ozkul H
No affiliation info available
Asicioglu F
No affiliation info available
Kasapoglu E
No affiliation info available
Bozkurt G
No affiliation info available
Konice M
No affiliation info available
Carin M
No affiliation info available

MeSH

AdultAllelesCase-Control StudiesDNAFemaleGenotypeHLA-B27 AntigenHumansMaleMiddle AgedPolymorphism, Single-Stranded ConformationalSpondylitis, AnkylosingTurkey

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15665390

Citation

Oguz, Fatma Savran, et al. "HLA B-27 Subtypes in Turkish Patients With Spondyloarthropathy and Healthy Controls." Disease Markers, vol. 20, no. 6, 2004, pp. 309-12.
Oguz FS, Ocal L, Diler AS, et al. HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls. Dis Markers. 2004;20(6):309-12.
Oguz, F. S., Ocal, L., Diler, A. S., Ozkul, H., Asicioglu, F., Kasapoglu, E., Bozkurt, G., Konice, M., & Carin, M. (2004). HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls. Disease Markers, 20(6), 309-12.
Oguz FS, et al. HLA B-27 Subtypes in Turkish Patients With Spondyloarthropathy and Healthy Controls. Dis Markers. 2004;20(6):309-12. PubMed PMID: 15665390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls. AU - Oguz,Fatma Savran, AU - Ocal,Lale, AU - Diler,Ali Sarper, AU - Ozkul,Hilmi, AU - Asicioglu,Faruk, AU - Kasapoglu,Esen, AU - Bozkurt,Gokay, AU - Konice,Meral, AU - Carin,Mahmut, PY - 2005/1/25/pubmed PY - 2005/5/6/medline PY - 2005/1/25/entrez SP - 309 EP - 12 JF - Disease markers JO - Dis Markers VL - 20 IS - 6 N2 - The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P=0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA. SN - 0278-0240 UR - https://www.unboundmedicine.com/medline/citation/15665390/HLA_B_27_subtypes_in_Turkish_patients_with_spondyloarthropathy_and_healthy_controls_ DB - PRIME DP - Unbound Medicine ER -