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Novel structures in marginal and intermediate cells presumably relate to functions of apical versus basal strial strata.
Hear Res. 2005 Feb; 200(1-2):87-101.HR

Abstract

Prior ultrastructural studies showed that K+ supplied to the stria vascularis came from recycling ions from the organ of Corti or perilymph to strial basal cells. A newly distinguished basal subtype of intermediate cell (BIC) completely covered the basal cells with a leaf-like horizontal process and appeared situated to absorb from them all of the recycled K+. The basal region of marginal cells (MCs) projected foot-like and enlarged processes to border BICs opposite an unique ca. 150 angstroms space. These basal MC processes appeared positioned to resorb part of the K+ recycled to BICs. A second, upper subtype of IC (UIC), occupying middle to upper strial strata, contacted BIC's extensively. UICs were thus located to resorb from BICs the portion of the recycled K+ not forwarded to basal MC processes. The apical segment of MCs projected mitochondria-filled primary processes and numerous associated secondary processes. The Na,K-ATPase-rich secondary processes populated mid to upper stria where they could siphon K+ from UICs and resorb and secrete the ions thus generating the 150 mM [KCl] of endolymph. The morphologic relationship of basal marginal cell processes to BICs differed so strikingly from the relation of upper MC processes to UICs as to suggest a different function for basal stria, one possibly concerned with generating the endocochlear potential.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, P.O. Box 250908, Charleston, SC 29425, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15668041

Citation

Spicer, Samuel S., and Bradley A. Schulte. "Novel Structures in Marginal and Intermediate Cells Presumably Relate to Functions of Apical Versus Basal Strial Strata." Hearing Research, vol. 200, no. 1-2, 2005, pp. 87-101.
Spicer SS, Schulte BA. Novel structures in marginal and intermediate cells presumably relate to functions of apical versus basal strial strata. Hear Res. 2005;200(1-2):87-101.
Spicer, S. S., & Schulte, B. A. (2005). Novel structures in marginal and intermediate cells presumably relate to functions of apical versus basal strial strata. Hearing Research, 200(1-2), 87-101.
Spicer SS, Schulte BA. Novel Structures in Marginal and Intermediate Cells Presumably Relate to Functions of Apical Versus Basal Strial Strata. Hear Res. 2005;200(1-2):87-101. PubMed PMID: 15668041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel structures in marginal and intermediate cells presumably relate to functions of apical versus basal strial strata. AU - Spicer,Samuel S, AU - Schulte,Bradley A, PY - 2004/06/10/received PY - 2004/09/09/accepted PY - 2005/1/26/pubmed PY - 2005/7/12/medline PY - 2005/1/26/entrez SP - 87 EP - 101 JF - Hearing research JO - Hear Res VL - 200 IS - 1-2 N2 - Prior ultrastructural studies showed that K+ supplied to the stria vascularis came from recycling ions from the organ of Corti or perilymph to strial basal cells. A newly distinguished basal subtype of intermediate cell (BIC) completely covered the basal cells with a leaf-like horizontal process and appeared situated to absorb from them all of the recycled K+. The basal region of marginal cells (MCs) projected foot-like and enlarged processes to border BICs opposite an unique ca. 150 angstroms space. These basal MC processes appeared positioned to resorb part of the K+ recycled to BICs. A second, upper subtype of IC (UIC), occupying middle to upper strial strata, contacted BIC's extensively. UICs were thus located to resorb from BICs the portion of the recycled K+ not forwarded to basal MC processes. The apical segment of MCs projected mitochondria-filled primary processes and numerous associated secondary processes. The Na,K-ATPase-rich secondary processes populated mid to upper stria where they could siphon K+ from UICs and resorb and secrete the ions thus generating the 150 mM [KCl] of endolymph. The morphologic relationship of basal marginal cell processes to BICs differed so strikingly from the relation of upper MC processes to UICs as to suggest a different function for basal stria, one possibly concerned with generating the endocochlear potential. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/15668041/Novel_structures_in_marginal_and_intermediate_cells_presumably_relate_to_functions_of_apical_versus_basal_strial_strata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5955(04)00310-7 DB - PRIME DP - Unbound Medicine ER -