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Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids.
Arch Intern Med. 2005 Jan 24; 165(2):193-9.AI

Abstract

BACKGROUND

Substitution of dietary polyunsaturated for saturated fat has long been recommended for the primary prevention of cardiovascular disease (CVD), but only a few prospective cohort studies have provided support for this advice.

METHODS

We assessed the association of dietary linoleic and total polyunsaturated fatty acid (PUFA) intake with cardiovascular and overall mortality in a population-based cohort of 1551 middle-aged men. Dietary fat composition was estimated with a 4-day food record and serum fatty acid composition.

RESULTS

During the 15-year follow-up, 78 men died of CVD and 225 of any cause. Total fat intake was not related to CVD or overall mortality. Men with an energy-adjusted dietary intake of linoleic acid (relative risk [RR] 0.39; 95% confidence interval [CI], 0.21-0.71) and PUFA (RR, 0.38; 95% CI, 0.20-0.70) in the upper third were less likely to die of CVD than men with intake in the lower third after adjustment for age. Multivariate adjustment weakened the association somewhat. Mortality from CVD was also lower for men with proportions of serum esterified linoleic acid (RR, 0.42; 95% CI, 0.21-0.80) and PUFA (RR, 0.25; 95% CI, 0.12-0.50) in the upper vs lower third, with some attenuation in multivariate analyses. Serum and to a lesser extent dietary linoleic acid and PUFA were also inversely associated with overall mortality.

CONCLUSIONS

Dietary polyunsaturated and more specifically linoleic fatty acid intake may have a substantial cardioprotective benefit that is also reflected in overall mortality. Dietary fat quality seems more important than fat quantity in the reduction of cardiovascular mortality in men.

Authors+Show Affiliations

Department of Physiology, University of Kuopio, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15668366

Citation

Laaksonen, David E., et al. "Prediction of Cardiovascular Mortality in Middle-aged Men By Dietary and Serum Linoleic and Polyunsaturated Fatty Acids." Archives of Internal Medicine, vol. 165, no. 2, 2005, pp. 193-9.
Laaksonen DE, Nyyssönen K, Niskanen L, et al. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med. 2005;165(2):193-9.
Laaksonen, D. E., Nyyssönen, K., Niskanen, L., Rissanen, T. H., & Salonen, J. T. (2005). Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Archives of Internal Medicine, 165(2), 193-9.
Laaksonen DE, et al. Prediction of Cardiovascular Mortality in Middle-aged Men By Dietary and Serum Linoleic and Polyunsaturated Fatty Acids. Arch Intern Med. 2005 Jan 24;165(2):193-9. PubMed PMID: 15668366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. AU - Laaksonen,David E, AU - Nyyssönen,Kristiina, AU - Niskanen,Leo, AU - Rissanen,Tiina H, AU - Salonen,Jukka T, PY - 2005/1/26/pubmed PY - 2005/2/18/medline PY - 2005/1/26/entrez SP - 193 EP - 9 JF - Archives of internal medicine JO - Arch Intern Med VL - 165 IS - 2 N2 - BACKGROUND: Substitution of dietary polyunsaturated for saturated fat has long been recommended for the primary prevention of cardiovascular disease (CVD), but only a few prospective cohort studies have provided support for this advice. METHODS: We assessed the association of dietary linoleic and total polyunsaturated fatty acid (PUFA) intake with cardiovascular and overall mortality in a population-based cohort of 1551 middle-aged men. Dietary fat composition was estimated with a 4-day food record and serum fatty acid composition. RESULTS: During the 15-year follow-up, 78 men died of CVD and 225 of any cause. Total fat intake was not related to CVD or overall mortality. Men with an energy-adjusted dietary intake of linoleic acid (relative risk [RR] 0.39; 95% confidence interval [CI], 0.21-0.71) and PUFA (RR, 0.38; 95% CI, 0.20-0.70) in the upper third were less likely to die of CVD than men with intake in the lower third after adjustment for age. Multivariate adjustment weakened the association somewhat. Mortality from CVD was also lower for men with proportions of serum esterified linoleic acid (RR, 0.42; 95% CI, 0.21-0.80) and PUFA (RR, 0.25; 95% CI, 0.12-0.50) in the upper vs lower third, with some attenuation in multivariate analyses. Serum and to a lesser extent dietary linoleic acid and PUFA were also inversely associated with overall mortality. CONCLUSIONS: Dietary polyunsaturated and more specifically linoleic fatty acid intake may have a substantial cardioprotective benefit that is also reflected in overall mortality. Dietary fat quality seems more important than fat quantity in the reduction of cardiovascular mortality in men. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15668366/Prediction_of_cardiovascular_mortality_in_middle_aged_men_by_dietary_and_serum_linoleic_and_polyunsaturated_fatty_acids_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.165.2.193 DB - PRIME DP - Unbound Medicine ER -