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Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women.

Abstract

We evaluated associations between reproductive and lifestyle risk factors with breast cancer tumor marker status in a case-control study. Cases were premenopausal women living in Vietnam and China who were eligible for a clinical trial of oophorectomy and tamoxifen as treatment for breast cancer (n = 682). Controls were nonrelative hospital visitors, matched on age to the cases (n = 649). Immunohistochemical analysis was used to identify the presence of estrogen receptor (ER) and progesterone receptor and the overexpression of HER-2/neu oncogene. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression, adjusted for known confounders. Overall, 280 (61%) tumor samples were ER positive and 176 (38%) were ER negative. HER-2/neu overexpression was detected in 161 (35%) samples, whereas 286 (26%) samples were HER-2/neu negative. We observed an inverse trend between increasing parity and decreasing breast cancer risk (P = 0.002). Women ages > or =25 years at first birth had increased breast cancer risk compared with women ages <25 years at first birth (OR, 1.53; 95% CI, 1.20-1.95). Women who consumed alcohol had increased risk of breast cancer compared with women who did not (OR,1.85; 95% CI, 1.32-2.61). Compared with controls, OR estimates for breast cancer by parity and age at first birth were significantly associated with ER and/or HER-2/neu tumor status by Wald test (P < 0.05). Family history, age at menarche, cumulative lactation, body mass index, and education were not significantly related to breast cancer risk. Our findings support the hypothesis that some breast cancer risk factors differ by ER and HER-2/neu tumor marker subtypes.

Authors+Show Affiliations

University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA. hbnichols@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15668474

Citation

Nichols, Hazel B., et al. "Differences in Breast Cancer Risk Factors By Tumor Marker Subtypes Among Premenopausal Vietnamese and Chinese Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 1, 2005, pp. 41-7.
Nichols HB, Trentham-Dietz A, Love RR, et al. Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women. Cancer Epidemiol Biomarkers Prev. 2005;14(1):41-7.
Nichols, H. B., Trentham-Dietz, A., Love, R. R., Hampton, J. M., Hoang Anh, P. T., Allred, D. C., ... Newcomb, P. A. (2005). Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(1), pp. 41-7.
Nichols HB, et al. Differences in Breast Cancer Risk Factors By Tumor Marker Subtypes Among Premenopausal Vietnamese and Chinese Women. Cancer Epidemiol Biomarkers Prev. 2005;14(1):41-7. PubMed PMID: 15668474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women. AU - Nichols,Hazel B, AU - Trentham-Dietz,Amy, AU - Love,Richard R, AU - Hampton,John M, AU - Hoang Anh,Pham Thi, AU - Allred,D Craig, AU - Mohsin,Syed K, AU - Newcomb,Polly A, PY - 2005/1/26/pubmed PY - 2005/4/21/medline PY - 2005/1/26/entrez SP - 41 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 1 N2 - We evaluated associations between reproductive and lifestyle risk factors with breast cancer tumor marker status in a case-control study. Cases were premenopausal women living in Vietnam and China who were eligible for a clinical trial of oophorectomy and tamoxifen as treatment for breast cancer (n = 682). Controls were nonrelative hospital visitors, matched on age to the cases (n = 649). Immunohistochemical analysis was used to identify the presence of estrogen receptor (ER) and progesterone receptor and the overexpression of HER-2/neu oncogene. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression, adjusted for known confounders. Overall, 280 (61%) tumor samples were ER positive and 176 (38%) were ER negative. HER-2/neu overexpression was detected in 161 (35%) samples, whereas 286 (26%) samples were HER-2/neu negative. We observed an inverse trend between increasing parity and decreasing breast cancer risk (P = 0.002). Women ages > or =25 years at first birth had increased breast cancer risk compared with women ages <25 years at first birth (OR, 1.53; 95% CI, 1.20-1.95). Women who consumed alcohol had increased risk of breast cancer compared with women who did not (OR,1.85; 95% CI, 1.32-2.61). Compared with controls, OR estimates for breast cancer by parity and age at first birth were significantly associated with ER and/or HER-2/neu tumor status by Wald test (P < 0.05). Family history, age at menarche, cumulative lactation, body mass index, and education were not significantly related to breast cancer risk. Our findings support the hypothesis that some breast cancer risk factors differ by ER and HER-2/neu tumor marker subtypes. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15668474/Differences_in_breast_cancer_risk_factors_by_tumor_marker_subtypes_among_premenopausal_Vietnamese_and_Chinese_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15668474 DB - PRIME DP - Unbound Medicine ER -