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Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men.

Abstract

Physical activity has been proposed as a modifiable risk factor for prostate cancer because of its potential effects on circulating hormones such as testosterone and insulin. We examined the association of various measures of physical activity with prostate cancer risk among men in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, a large prospective study of U.S. adults. Information on recreational physical activity was obtained from a self-administered questionnaire completed at cohort enrollment in 1992/1993, as well as from a questionnaire completed as part of an earlier study in 1982. During the 9-year prospective follow-up, 5,503 incident prostate cancer cases were identified among 72,174 men who were cancer-free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios (RR) for measures of recreational physical activity and to adjust for potential confounding factors. We observed no difference in risk of prostate cancer between men who engaged in the highest level of recreational physical activity (>35 metabolic equivalent-hours/wk) and those who reported no recreational physical activity at baseline (RR, 0.90; 95% confidence interval, 0.78-1.04; P for trend = 0.31). We also did not observe an association between prostate cancer and recalled physical activity at age 40 or exercise reported in 1982. However, the incidence of aggressive prostate cancer was inversely associated with >35 metabolic equivalent-hours/wk of recreational physical activity compared with that in men who reported no recreational physical activity (RR, 0.69; 95% confidence interval, 0.52-0.92; P for trend = 0.06). Our findings are consistent with most previous studies that found no association between recreational physical activity and overall prostate cancer risk but suggest physical activity may be associated with reduced risk of aggressive prostate cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, 1599 Clifton Road Northeast, Atlanta, GA 30329-4251, USA. Alpa.Patel@cancer.org

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Exercise
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Recreation
    Risk Assessment
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15668508

    Citation

    Patel, Alpa V., et al. "Recreational Physical Activity and Risk of Prostate Cancer in a Large Cohort of U.S. Men." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 1, 2005, pp. 275-9.
    Patel AV, Rodriguez C, Jacobs EJ, et al. Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men. Cancer Epidemiol Biomarkers Prev. 2005;14(1):275-9.
    Patel, A. V., Rodriguez, C., Jacobs, E. J., Solomon, L., Thun, M. J., & Calle, E. E. (2005). Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(1), pp. 275-9.
    Patel AV, et al. Recreational Physical Activity and Risk of Prostate Cancer in a Large Cohort of U.S. Men. Cancer Epidemiol Biomarkers Prev. 2005;14(1):275-9. PubMed PMID: 15668508.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men. AU - Patel,Alpa V, AU - Rodriguez,Carmen, AU - Jacobs,Eric J, AU - Solomon,Laura, AU - Thun,Michael J, AU - Calle,Eugenia E, PY - 2005/1/26/pubmed PY - 2005/4/21/medline PY - 2005/1/26/entrez SP - 275 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 1 N2 - Physical activity has been proposed as a modifiable risk factor for prostate cancer because of its potential effects on circulating hormones such as testosterone and insulin. We examined the association of various measures of physical activity with prostate cancer risk among men in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, a large prospective study of U.S. adults. Information on recreational physical activity was obtained from a self-administered questionnaire completed at cohort enrollment in 1992/1993, as well as from a questionnaire completed as part of an earlier study in 1982. During the 9-year prospective follow-up, 5,503 incident prostate cancer cases were identified among 72,174 men who were cancer-free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios (RR) for measures of recreational physical activity and to adjust for potential confounding factors. We observed no difference in risk of prostate cancer between men who engaged in the highest level of recreational physical activity (>35 metabolic equivalent-hours/wk) and those who reported no recreational physical activity at baseline (RR, 0.90; 95% confidence interval, 0.78-1.04; P for trend = 0.31). We also did not observe an association between prostate cancer and recalled physical activity at age 40 or exercise reported in 1982. However, the incidence of aggressive prostate cancer was inversely associated with >35 metabolic equivalent-hours/wk of recreational physical activity compared with that in men who reported no recreational physical activity (RR, 0.69; 95% confidence interval, 0.52-0.92; P for trend = 0.06). Our findings are consistent with most previous studies that found no association between recreational physical activity and overall prostate cancer risk but suggest physical activity may be associated with reduced risk of aggressive prostate cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15668508/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15668508 DB - PRIME DP - Unbound Medicine ER -