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Evidence of the glyoxylate cycle in the liver of newborn rats.
Med Sci Monit. 2005 Feb; 11(2):BR57-60.MS

Abstract

RESULTS

BACKGROUND

It is generally accepted that the glyoxylate cycle exists in microorganisms and higher plants but absent in higher animals. the hypodhesis of the glyoxylate cycle in the tissues of higher animals with a high level of physiological activity was first proposed by Kondrashova and Rodionova in 1971. The goal of this work was yo verifv this in newborn rats, which possess a 2.5-fold hygher physiological activity and oxygen consumption rate than adult rats.

MATERIAL/METHODS

Newborn (7-day-old) anradult 1 ats were used for this experiment. The activities of the key enzymes of the glyoxylate cocle (isecitrate lyse and nmalate synthase) were measured by HPLC and spectroscopic methods. The activities of isocitrate lyase and malate synthase were found in the liver homogenates prepared from newborn rats, but not from adult rats. The activities of the enzymes common to both the Krebs cycle and the glyoxylate cycle (citrate synthase, aconitase, and malate dehydrogenase) were 20-40% higher in newborn than in adult rats.

CONCLUSIONS

These data indicate the existence of the glyoxylate cycle in animal tissues.

Authors+Show Affiliations

Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Russian Federation.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15668627

Citation

Morgunov, Igor G., et al. "Evidence of the Glyoxylate Cycle in the Liver of Newborn Rats." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 11, no. 2, 2005, pp. BR57-60.
Morgunov IG, Kondrashova MN, Kamzolova SV, et al. Evidence of the glyoxylate cycle in the liver of newborn rats. Med Sci Monit. 2005;11(2):BR57-60.
Morgunov, I. G., Kondrashova, M. N., Kamzolova, S. V., Sokolov, A. P., Fedotcheva, N. I., & Finogenova, T. V. (2005). Evidence of the glyoxylate cycle in the liver of newborn rats. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 11(2), BR57-60.
Morgunov IG, et al. Evidence of the Glyoxylate Cycle in the Liver of Newborn Rats. Med Sci Monit. 2005;11(2):BR57-60. PubMed PMID: 15668627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of the glyoxylate cycle in the liver of newborn rats. AU - Morgunov,Igor G, AU - Kondrashova,Maria N, AU - Kamzolova,Svetlana V, AU - Sokolov,Alexander P, AU - Fedotcheva,Nadezhda I, AU - Finogenova,Tatiana V, PY - 2004/02/25/received PY - 2004/05/27/accepted PY - 2005/1/26/pubmed PY - 2005/5/19/medline PY - 2005/1/26/entrez SP - BR57 EP - 60 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 11 IS - 2 N2 - RESULTS: BACKGROUND: It is generally accepted that the glyoxylate cycle exists in microorganisms and higher plants but absent in higher animals. the hypodhesis of the glyoxylate cycle in the tissues of higher animals with a high level of physiological activity was first proposed by Kondrashova and Rodionova in 1971. The goal of this work was yo verifv this in newborn rats, which possess a 2.5-fold hygher physiological activity and oxygen consumption rate than adult rats. MATERIAL/METHODS: Newborn (7-day-old) anradult 1 ats were used for this experiment. The activities of the key enzymes of the glyoxylate cocle (isecitrate lyse and nmalate synthase) were measured by HPLC and spectroscopic methods. The activities of isocitrate lyase and malate synthase were found in the liver homogenates prepared from newborn rats, but not from adult rats. The activities of the enzymes common to both the Krebs cycle and the glyoxylate cycle (citrate synthase, aconitase, and malate dehydrogenase) were 20-40% higher in newborn than in adult rats. CONCLUSIONS: These data indicate the existence of the glyoxylate cycle in animal tissues. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/15668627/Evidence_of_the_glyoxylate_cycle_in_the_liver_of_newborn_rats_ L2 - https://www.medscimonit.com/download/index/idArt/14143 DB - PRIME DP - Unbound Medicine ER -