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Vascular endothelial growth factor A and C gene expression in endometriosis.
Hum Pathol. 2004 Nov; 35(11):1369-75.HP

Abstract

Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle (P <0.01) and increased in the secretory phase. VEGF-A gene expression in peritoneal endometriotic lesion was statistically higher than that in normal peritoneum (P <0.01) and similar to that in eutopic endometrium of group 2. In contrast, gene expression levels of VEGF-C were relatively lower than those of VEGF-A in each lesion, and no cyclic variation was found. VEGF-A and C mRNA expression levels were significantly higher in ovarian endometriomas >6 cm in size than in those <6 cm in size. Immunohistochemical expression of VEGF-A and C was detected in the cytoplasm of glandular epithelial and stromal cells of ovarian endometrioma. These results suggest that endometriosis may arise from eutopic endometrium with higher levels of angiogenic activity possibly induced by VEGF-A in women with endometriosis. Moreover, VEGF-C as well as VEGF-A may be involved in the pathogenesis of ovarian endometrioma.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Osaka Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15668894

Citation

Takehara, Mikio, et al. "Vascular Endothelial Growth Factor a and C Gene Expression in Endometriosis." Human Pathology, vol. 35, no. 11, 2004, pp. 1369-75.
Takehara M, Ueda M, Yamashita Y, et al. Vascular endothelial growth factor A and C gene expression in endometriosis. Hum Pathol. 2004;35(11):1369-75.
Takehara, M., Ueda, M., Yamashita, Y., Terai, Y., Hung, Y. C., & Ueki, M. (2004). Vascular endothelial growth factor A and C gene expression in endometriosis. Human Pathology, 35(11), 1369-75.
Takehara M, et al. Vascular Endothelial Growth Factor a and C Gene Expression in Endometriosis. Hum Pathol. 2004;35(11):1369-75. PubMed PMID: 15668894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular endothelial growth factor A and C gene expression in endometriosis. AU - Takehara,Mikio, AU - Ueda,Masatsugu, AU - Yamashita,Yoshiki, AU - Terai,Yoshito, AU - Hung,Yao-Ching, AU - Ueki,Minoru, PY - 2005/1/26/pubmed PY - 2005/2/9/medline PY - 2005/1/26/entrez SP - 1369 EP - 75 JF - Human pathology JO - Hum. Pathol. VL - 35 IS - 11 N2 - Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle (P <0.01) and increased in the secretory phase. VEGF-A gene expression in peritoneal endometriotic lesion was statistically higher than that in normal peritoneum (P <0.01) and similar to that in eutopic endometrium of group 2. In contrast, gene expression levels of VEGF-C were relatively lower than those of VEGF-A in each lesion, and no cyclic variation was found. VEGF-A and C mRNA expression levels were significantly higher in ovarian endometriomas >6 cm in size than in those <6 cm in size. Immunohistochemical expression of VEGF-A and C was detected in the cytoplasm of glandular epithelial and stromal cells of ovarian endometrioma. These results suggest that endometriosis may arise from eutopic endometrium with higher levels of angiogenic activity possibly induced by VEGF-A in women with endometriosis. Moreover, VEGF-C as well as VEGF-A may be involved in the pathogenesis of ovarian endometrioma. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/15668894/Vascular_endothelial_growth_factor_A_and_C_gene_expression_in_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S004681770400437X DB - PRIME DP - Unbound Medicine ER -