Tags

Type your tag names separated by a space and hit enter

Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease.
Neurogastroenterol Motil. 2005 Feb; 17(1):23-8.NM

Abstract

AIM

To calculate the number of subjects required in trials investigating drugs reducing the number of transient lower oesophageal sphincter relaxations (TLOSRs), the inter- and intra-individual variability of TLOSRs were determined, using meal ingestion as a trigger of TLOSRs and reflux.

METHODS

A total of 23 gastro-oesophageal reflux disease (GORD) patients with no to grade B oesophagitis and a hiatal hernia < or =3 cm underwent oesophageal manometry and pHmetry 1 h before and 3 h after ingestion of a solid meal on two separate days approximately 4 weeks apart. Reflux episodes and the underlying mechanisms and the number of TLOSRs were evaluated.

RESULTS

The number of TLOSRs, reflux episodes and % time with pH < 4 after meal ingestion did not differ significantly between the two sessions. The intra-individual variation of TLOSRs in the 3 h postprandial period (24.4) was smaller compared with the inter-individual variation (47.5). Transient lower oesophageal sphincter relaxations were the predominant cause of reflux accounting for 61 +/- 7 and 70 +/- 5% of the reflux episodes in visits 1 and 2, respectively.

CONCLUSIONS

These data for the first time provide information on the variability of TLOSRs and reflux evoked by meal ingestion, which is of crucial importance for the design and power calculations of future clinical studies evaluating the efficacy of new drugs targeting TLOSRs.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. g.e.boeckxstaens@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15670260

Citation

Boeckxstaens, G E., et al. "Reproducibility of Meal-induced Transient Lower Oesophageal Sphincter Relaxations in Patients With Gastro-oesophageal Reflux Disease." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 17, no. 1, 2005, pp. 23-8.
Boeckxstaens GE, Hirsch DP, Verkleij CB, et al. Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease. Neurogastroenterol Motil. 2005;17(1):23-8.
Boeckxstaens, G. E., Hirsch, D. P., Verkleij, C. B., Lei, A., Holman, R., Lehmann, A., & Rydholm, H. (2005). Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 17(1), 23-8.
Boeckxstaens GE, et al. Reproducibility of Meal-induced Transient Lower Oesophageal Sphincter Relaxations in Patients With Gastro-oesophageal Reflux Disease. Neurogastroenterol Motil. 2005;17(1):23-8. PubMed PMID: 15670260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of meal-induced transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease. AU - Boeckxstaens,G E, AU - Hirsch,D P, AU - Verkleij,C B, AU - Lei,A, AU - Holman,R, AU - Lehmann,A, AU - Rydholm,H, PY - 2005/1/27/pubmed PY - 2005/3/10/medline PY - 2005/1/27/entrez SP - 23 EP - 8 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 17 IS - 1 N2 - AIM: To calculate the number of subjects required in trials investigating drugs reducing the number of transient lower oesophageal sphincter relaxations (TLOSRs), the inter- and intra-individual variability of TLOSRs were determined, using meal ingestion as a trigger of TLOSRs and reflux. METHODS: A total of 23 gastro-oesophageal reflux disease (GORD) patients with no to grade B oesophagitis and a hiatal hernia < or =3 cm underwent oesophageal manometry and pHmetry 1 h before and 3 h after ingestion of a solid meal on two separate days approximately 4 weeks apart. Reflux episodes and the underlying mechanisms and the number of TLOSRs were evaluated. RESULTS: The number of TLOSRs, reflux episodes and % time with pH < 4 after meal ingestion did not differ significantly between the two sessions. The intra-individual variation of TLOSRs in the 3 h postprandial period (24.4) was smaller compared with the inter-individual variation (47.5). Transient lower oesophageal sphincter relaxations were the predominant cause of reflux accounting for 61 +/- 7 and 70 +/- 5% of the reflux episodes in visits 1 and 2, respectively. CONCLUSIONS: These data for the first time provide information on the variability of TLOSRs and reflux evoked by meal ingestion, which is of crucial importance for the design and power calculations of future clinical studies evaluating the efficacy of new drugs targeting TLOSRs. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/15670260/Reproducibility_of_meal_induced_transient_lower_oesophageal_sphincter_relaxations_in_patients_with_gastro_oesophageal_reflux_disease_ L2 - https://doi.org/10.1111/j.1365-2982.2004.00610.x DB - PRIME DP - Unbound Medicine ER -