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Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein.
Ann Pharmacother. 2005 Mar; 39(3):523-6.AP

Abstract

OBJECTIVE

To review the effects of lipid-lowering therapy on small-dense low-density lipoprotein cholesterol (sdLDL-C).

DATA SOURCES

Literature was obtained from MEDLINE (1989-September 2004) and references of selected articles. Key search terms included small-dense LDL-C and lipid-lowering drug therapy.

DATA SYNTHESIS

Statins, fibrates, and niacin have demonstrated favorable effects on sdLDL-C, especially among patients with mixed dyslipidemia or hypertriglyceridemia. These effects include a reduction of sdLDL-C and/or a shift to the larger, less atherogenic LDL-C.

CONCLUSIONS

Data suggest that statins, fibrates, and niacin are effective at reducing concentrations of sdLDL-C and possibly normalizing LDL-C subclasses.

Authors+Show Affiliations

Backes JM
Department of Pharmacy Practice, School of Pharmacy, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7231, USA. jbackes@kumc.edu
Gibson CA
No affiliation info available

MeSH

Cholesterol, LDLClofibric AcidHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasHypolipidemic AgentsNiacinRandomized Controlled Trials as Topic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15671087

Citation

Backes, James M., and Cheryl A. Gibson. "Effect of Lipid-lowering Drug Therapy On Small-dense Low-density Lipoprotein." The Annals of Pharmacotherapy, vol. 39, no. 3, 2005, pp. 523-6.
Backes JM, Gibson CA. Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein. Ann Pharmacother. 2005;39(3):523-6.
Backes, J. M., & Gibson, C. A. (2005). Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein. The Annals of Pharmacotherapy, 39(3), 523-6.
Backes JM, Gibson CA. Effect of Lipid-lowering Drug Therapy On Small-dense Low-density Lipoprotein. Ann Pharmacother. 2005;39(3):523-6. PubMed PMID: 15671087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein. AU - Backes,James M, AU - Gibson,Cheryl A, Y1 - 2005/01/25/ PY - 2005/1/27/pubmed PY - 2005/5/7/medline PY - 2005/1/27/entrez SP - 523 EP - 6 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 39 IS - 3 N2 - OBJECTIVE: To review the effects of lipid-lowering therapy on small-dense low-density lipoprotein cholesterol (sdLDL-C). DATA SOURCES: Literature was obtained from MEDLINE (1989-September 2004) and references of selected articles. Key search terms included small-dense LDL-C and lipid-lowering drug therapy. DATA SYNTHESIS: Statins, fibrates, and niacin have demonstrated favorable effects on sdLDL-C, especially among patients with mixed dyslipidemia or hypertriglyceridemia. These effects include a reduction of sdLDL-C and/or a shift to the larger, less atherogenic LDL-C. CONCLUSIONS: Data suggest that statins, fibrates, and niacin are effective at reducing concentrations of sdLDL-C and possibly normalizing LDL-C subclasses. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/15671087/Effect_of_lipid_lowering_drug_therapy_on_small_dense_low_density_lipoprotein_ DB - PRIME DP - Unbound Medicine ER -