Tags

Type your tag names separated by a space and hit enter

What are capillary blood ketone levels in type 1 diabetic patients using CSII in normal conditions of insulin delivery?
Diabetes Metab. 2004 Dec; 30(6):543-7.DM

Abstract

OBJECTIVE

The aim of the study was to determine the normal level of capillary ketonemia in type 1 diabetic patients on continuous subcutaneous insulin infusion (CSII).

RESEARCH DESIGN AND METHODS

A total of 36 type 1 diabetic patients treated by external pump were studied for 2 to 3 weeks. Patients were instructed to self monitor capillary glucose and capillary ketone bodies at least 4 times per day with a handheld Medisense Optium meter and check for urinary ketone bodies in the morning and when blood glucose exceeded 2.5 g/l with a semiquantitative test. Data were collected and analysed for each period of time defined as the time interval between two changes of the infusion site. A period was considered "normal" when no problem causing any impairment in insulin delivery was detected.

RESULTS

186 periods of 2.1 +/- 0.9 days were recorded; 119 were considered normal. 1281 coupled values of glucose and betahydroxybutyrate were analysed during the so called normal periods. Mean percentage of ketonemia of 0, 0.1, 0.2, > or =0.3 mmole/l were 81.3%, 13%, 3.7% and 2% respectively whereas mean glucose level (g/l) was 1.49 +/- 0.7, 1.48 +/- 0.7, 1.59 +/- 0.8 and 1.89 +/- 0.9 respectively. Only 0.9% of betahydroxybutyrate values were > or =0.3 mmole/l when blood glucose exceeded 2.5 g/l.

CONCLUSION

Our study indicates that ketonemia self monitoring can be a valuable tool to screen insulin deficiency in patients on CSII with a low risk of false positive if we consider a threshold of 0.3 mmole/l for ketone bodies.

Authors+Show Affiliations

Department of Diabetology and Metabolic Diseases, University Hospital of Rangueil, CHU Ranguiel, 1 avenue J. Poulhes, Toulouse Cedex 09, France. matta.m@chu-toulouse.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15671924

Citation

Matta, M P., et al. "What Are Capillary Blood Ketone Levels in Type 1 Diabetic Patients Using CSII in Normal Conditions of Insulin Delivery?" Diabetes & Metabolism, vol. 30, no. 6, 2004, pp. 543-7.
Matta MP, Melki V, Bessière-Lacombe S, et al. What are capillary blood ketone levels in type 1 diabetic patients using CSII in normal conditions of insulin delivery? Diabetes Metab. 2004;30(6):543-7.
Matta, M. P., Melki, V., Bessière-Lacombe, S., & Hanaire-Broutin, H. (2004). What are capillary blood ketone levels in type 1 diabetic patients using CSII in normal conditions of insulin delivery? Diabetes & Metabolism, 30(6), 543-7.
Matta MP, et al. What Are Capillary Blood Ketone Levels in Type 1 Diabetic Patients Using CSII in Normal Conditions of Insulin Delivery. Diabetes Metab. 2004;30(6):543-7. PubMed PMID: 15671924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What are capillary blood ketone levels in type 1 diabetic patients using CSII in normal conditions of insulin delivery? AU - Matta,M P, AU - Melki,V, AU - Bessière-Lacombe,S, AU - Hanaire-Broutin,H, PY - 2005/1/27/pubmed PY - 2005/2/23/medline PY - 2005/1/27/entrez SP - 543 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 30 IS - 6 N2 - OBJECTIVE: The aim of the study was to determine the normal level of capillary ketonemia in type 1 diabetic patients on continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND METHODS: A total of 36 type 1 diabetic patients treated by external pump were studied for 2 to 3 weeks. Patients were instructed to self monitor capillary glucose and capillary ketone bodies at least 4 times per day with a handheld Medisense Optium meter and check for urinary ketone bodies in the morning and when blood glucose exceeded 2.5 g/l with a semiquantitative test. Data were collected and analysed for each period of time defined as the time interval between two changes of the infusion site. A period was considered "normal" when no problem causing any impairment in insulin delivery was detected. RESULTS: 186 periods of 2.1 +/- 0.9 days were recorded; 119 were considered normal. 1281 coupled values of glucose and betahydroxybutyrate were analysed during the so called normal periods. Mean percentage of ketonemia of 0, 0.1, 0.2, > or =0.3 mmole/l were 81.3%, 13%, 3.7% and 2% respectively whereas mean glucose level (g/l) was 1.49 +/- 0.7, 1.48 +/- 0.7, 1.59 +/- 0.8 and 1.89 +/- 0.9 respectively. Only 0.9% of betahydroxybutyrate values were > or =0.3 mmole/l when blood glucose exceeded 2.5 g/l. CONCLUSION: Our study indicates that ketonemia self monitoring can be a valuable tool to screen insulin deficiency in patients on CSII with a low risk of false positive if we consider a threshold of 0.3 mmole/l for ketone bodies. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/15671924/What_are_capillary_blood_ketone_levels_in_type_1_diabetic_patients_using_CSII_in_normal_conditions_of_insulin_delivery L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-DM-12-2004-30-6-1262-3636-101019-ART8 DB - PRIME DP - Unbound Medicine ER -