Tags

Type your tag names separated by a space and hit enter

A randomized trial of plasma volume expansion in hypertensive disorders of pregnancy: influence on the pulsatility indices of the fetal umbilical artery and middle cerebral artery.
Am J Obstet Gynecol. 2005 Jan; 192(1):233-9.AJ

Abstract

OBJECTIVE

The purpose of this study was to investigate the effect of plasma volume expansion on the pulsatility indices of the fetal umbilical and middle cerebral arteries.

STUDY DESIGN

Two hundred sixteen patients with severe preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, eclampsia, hypertension-related fetal growth restriction, and gestational ages between 24 and 34 completed weeks of gestation were assigned randomly for temporizing treatment with plasma volume expansion (n = 111 patients; 250 mL hydroxyethyl starch 6% twice daily in 4 hours, and NaCl 0.9% between doses of hydroxyethyl starch and with intravenous medication) or without plasma volume expansion (n = 105; only NaCl 0.9% when necessary with medication). Measurements of the pulsatility index of the umbilical and middle cerebral arteries were performed at admission, after 16 to 48 hours, 60 to 120 hours, and 7 to 11 days.

RESULTS

Median gestational age was 30 weeks in both groups. Infused volumes of plasma volume expansion in the treatment group (total median, 813 mL/d) were associated with a significant decrease of hemoglobin concentration. Changes from baseline measurements of the umbilical and middle cerebral arteries were not different between the groups nor within subgroups during the first 7 to 11 days.

CONCLUSION

Plasma volume expansion did not influence the pulsatility indices of the umbilical and middle cerebral arteries.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands. j.w.ganzevoort@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15672030

Citation

Ganzevoort, Wessel, et al. "A Randomized Trial of Plasma Volume Expansion in Hypertensive Disorders of Pregnancy: Influence On the Pulsatility Indices of the Fetal Umbilical Artery and Middle Cerebral Artery." American Journal of Obstetrics and Gynecology, vol. 192, no. 1, 2005, pp. 233-9.
Ganzevoort W, Rep A, Bonsel GJ, et al. A randomized trial of plasma volume expansion in hypertensive disorders of pregnancy: influence on the pulsatility indices of the fetal umbilical artery and middle cerebral artery. Am J Obstet Gynecol. 2005;192(1):233-9.
Ganzevoort, W., Rep, A., Bonsel, G. J., De Vries, J. I., & Wolf, H. (2005). A randomized trial of plasma volume expansion in hypertensive disorders of pregnancy: influence on the pulsatility indices of the fetal umbilical artery and middle cerebral artery. American Journal of Obstetrics and Gynecology, 192(1), 233-9.
Ganzevoort W, et al. A Randomized Trial of Plasma Volume Expansion in Hypertensive Disorders of Pregnancy: Influence On the Pulsatility Indices of the Fetal Umbilical Artery and Middle Cerebral Artery. Am J Obstet Gynecol. 2005;192(1):233-9. PubMed PMID: 15672030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized trial of plasma volume expansion in hypertensive disorders of pregnancy: influence on the pulsatility indices of the fetal umbilical artery and middle cerebral artery. AU - Ganzevoort,Wessel, AU - Rep,Annelies, AU - Bonsel,Gouke J, AU - De Vries,Johanna I P, AU - Wolf,Hans, AU - ,, PY - 2005/1/27/pubmed PY - 2005/3/4/medline PY - 2005/1/27/entrez SP - 233 EP - 9 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 192 IS - 1 N2 - OBJECTIVE: The purpose of this study was to investigate the effect of plasma volume expansion on the pulsatility indices of the fetal umbilical and middle cerebral arteries. STUDY DESIGN: Two hundred sixteen patients with severe preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, eclampsia, hypertension-related fetal growth restriction, and gestational ages between 24 and 34 completed weeks of gestation were assigned randomly for temporizing treatment with plasma volume expansion (n = 111 patients; 250 mL hydroxyethyl starch 6% twice daily in 4 hours, and NaCl 0.9% between doses of hydroxyethyl starch and with intravenous medication) or without plasma volume expansion (n = 105; only NaCl 0.9% when necessary with medication). Measurements of the pulsatility index of the umbilical and middle cerebral arteries were performed at admission, after 16 to 48 hours, 60 to 120 hours, and 7 to 11 days. RESULTS: Median gestational age was 30 weeks in both groups. Infused volumes of plasma volume expansion in the treatment group (total median, 813 mL/d) were associated with a significant decrease of hemoglobin concentration. Changes from baseline measurements of the umbilical and middle cerebral arteries were not different between the groups nor within subgroups during the first 7 to 11 days. CONCLUSION: Plasma volume expansion did not influence the pulsatility indices of the umbilical and middle cerebral arteries. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/15672030/A_randomized_trial_of_plasma_volume_expansion_in_hypertensive_disorders_of_pregnancy:_influence_on_the_pulsatility_indices_of_the_fetal_umbilical_artery_and_middle_cerebral_artery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937804006611 DB - PRIME DP - Unbound Medicine ER -