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Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III).
Int J Obes (Lond) 2005; 29(3):310-6IJ

Abstract

OBJECTIVE

To examine the association of components of the metabolic syndrome with lower urinary tract symptoms (LUTS), which often result from prostate enlargement and heightened tone of prostate and bladder smooth muscle.

DESIGN

Third National Health and Examination Survey (NHANES III), from which LUTS cases and controls were selected.

SUBJECTS

A total of 2372 men aged 60+ y who participated in NHANES III. LUTS cases were men with at least three of these four symptoms: nocturia, incomplete bladder emptying, weak stream, and hesitancy, and who never had noncancer prostate surgery. Controls were men without any of the symptoms and who never had noncancer prostate surgery.

MEASUREMENTS

As part of NHANES III, an oral glucose tolerance test was carried out, glycosylated hemoglobin, HDL and LDL cholesterol, and triglycerides were measured, and history of diabetes mellitus and hypertension were assessed. Logistic regression was used to calculate odds ratios (ORs) after applying sampling weights.

RESULTS

History of diabetes (OR 1.67; 95% confidence interval (CI) 0.72-3.86) and hypertension (OR 1.76; 95% CI 1.20-2.59) appeared to be positively associated with LUTS. The odds of LUTS increased with increasing glycosylated hemoglobin (P-trend = 0.005). No statistically significant associations between fasting or 2-h glucose or fasting insulin and LUTS were observed. However, men classified as having three or more components of the metabolic syndrome had an increased odds of LUTS (OR = 1.80; 95% CI 1.11-2.94).

CONCLUSION

These findings support the role for metabolic perturbations in the etiology of LUTS.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15672112

Citation

Rohrmann, S, et al. "Association Between Markers of the Metabolic Syndrome and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey (NHANES III)." International Journal of Obesity (2005), vol. 29, no. 3, 2005, pp. 310-6.
Rohrmann S, Smit E, Giovannucci E, et al. Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). Int J Obes (Lond). 2005;29(3):310-6.
Rohrmann, S., Smit, E., Giovannucci, E., & Platz, E. A. (2005). Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). International Journal of Obesity (2005), 29(3), pp. 310-6.
Rohrmann S, et al. Association Between Markers of the Metabolic Syndrome and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). Int J Obes (Lond). 2005;29(3):310-6. PubMed PMID: 15672112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). AU - Rohrmann,S, AU - Smit,E, AU - Giovannucci,E, AU - Platz,E A, PY - 2005/1/27/pubmed PY - 2005/6/7/medline PY - 2005/1/27/entrez SP - 310 EP - 6 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 29 IS - 3 N2 - OBJECTIVE: To examine the association of components of the metabolic syndrome with lower urinary tract symptoms (LUTS), which often result from prostate enlargement and heightened tone of prostate and bladder smooth muscle. DESIGN: Third National Health and Examination Survey (NHANES III), from which LUTS cases and controls were selected. SUBJECTS: A total of 2372 men aged 60+ y who participated in NHANES III. LUTS cases were men with at least three of these four symptoms: nocturia, incomplete bladder emptying, weak stream, and hesitancy, and who never had noncancer prostate surgery. Controls were men without any of the symptoms and who never had noncancer prostate surgery. MEASUREMENTS: As part of NHANES III, an oral glucose tolerance test was carried out, glycosylated hemoglobin, HDL and LDL cholesterol, and triglycerides were measured, and history of diabetes mellitus and hypertension were assessed. Logistic regression was used to calculate odds ratios (ORs) after applying sampling weights. RESULTS: History of diabetes (OR 1.67; 95% confidence interval (CI) 0.72-3.86) and hypertension (OR 1.76; 95% CI 1.20-2.59) appeared to be positively associated with LUTS. The odds of LUTS increased with increasing glycosylated hemoglobin (P-trend = 0.005). No statistically significant associations between fasting or 2-h glucose or fasting insulin and LUTS were observed. However, men classified as having three or more components of the metabolic syndrome had an increased odds of LUTS (OR = 1.80; 95% CI 1.11-2.94). CONCLUSION: These findings support the role for metabolic perturbations in the etiology of LUTS. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/15672112/Association_between_markers_of_the_metabolic_syndrome_and_lower_urinary_tract_symptoms_in_the_Third_National_Health_and_Nutrition_Examination_Survey__NHANES_III__ L2 - http://dx.doi.org/10.1038/sj.ijo.0802881 DB - PRIME DP - Unbound Medicine ER -