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Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency.
Aging Male. 2004 Jun; 7(2):133-43.AM

Abstract

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) age-related withdrawal is very likely to be involved in the aging process and the onset of age-related diseases, giving rise to the question of whether preventing or compensating the decline of these steroids may have endocrine and clinical benefits. The aim of the present trial was to evaluate the endocrine, neuroendocrine and clinical consequences of a long-term (1 year), low-dose (25 mg/day) replacement therapy in a group of aging men who presented the clinical characteristics of partial androgen deficiency (PADAM). Circulating DHEA, DHEAS, androstenedione, total testosterone and free testosterone, dihydrotestosterone (DHT), progesterone, 17-hydroxyprogesterone, allopregnanolone, estrone, estradiol, sex hormone binding globulin (SHBG), cortisol, follicle stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were evaluated monthly to assess the endocrine effects of the therapy, while beta-endorphin values were used as a marker of the neuroendocrine effects. A Kupperman questionnaire was performed to evaluate the subjective symptoms before and after treatment. The results showed a great modification of the endocrine profile; with the exception of cortisol levels, which remained unchanged, DHEA, DHEAS, androstenedione, total and free testosterone, DHT, progesterone, 17-hydroxyprogesterone, estrone, estradiol, GH, IGF-1 and beta-endorphin levels increased significantly with respect to baseline values, while FSH, LH and SHBG levels showed a significant decrease. The Kupperman score indicated a progressive improvement in mood, fatigue and joint pain. In conclusion, the present study demonstrates that 25 mg/day of DHEA is able to cause significant changes in the hormonal profile and clinical symptoms and can counteract the age-related decline of endocrine and neuroendocrine functions. Restoring DHEA levels to young adult values seems to benefit the age-related decline in physiological functions but, however promising, placebo-controlled trials are required to confirm these preliminary results.

Authors+Show Affiliations

Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15672938

Citation

Genazzani, A R., et al. "Long-term Low-dose Dehydroepiandrosterone Replacement Therapy in Aging Males With Partial Androgen Deficiency." The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, vol. 7, no. 2, 2004, pp. 133-43.
Genazzani AR, Inglese S, Lombardi I, et al. Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. Aging Male. 2004;7(2):133-43.
Genazzani, A. R., Inglese, S., Lombardi, I., Pieri, M., Bernardi, F., Genazzani, A. D., Rovati, L., & Luisi, M. (2004). Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 7(2), 133-43.
Genazzani AR, et al. Long-term Low-dose Dehydroepiandrosterone Replacement Therapy in Aging Males With Partial Androgen Deficiency. Aging Male. 2004;7(2):133-43. PubMed PMID: 15672938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. AU - Genazzani,A R, AU - Inglese,S, AU - Lombardi,I, AU - Pieri,M, AU - Bernardi,F, AU - Genazzani,A D, AU - Rovati,L, AU - Luisi,M, PY - 2005/1/28/pubmed PY - 2005/2/23/medline PY - 2005/1/28/entrez SP - 133 EP - 43 JF - The aging male : the official journal of the International Society for the Study of the Aging Male JO - Aging Male VL - 7 IS - 2 N2 - Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) age-related withdrawal is very likely to be involved in the aging process and the onset of age-related diseases, giving rise to the question of whether preventing or compensating the decline of these steroids may have endocrine and clinical benefits. The aim of the present trial was to evaluate the endocrine, neuroendocrine and clinical consequences of a long-term (1 year), low-dose (25 mg/day) replacement therapy in a group of aging men who presented the clinical characteristics of partial androgen deficiency (PADAM). Circulating DHEA, DHEAS, androstenedione, total testosterone and free testosterone, dihydrotestosterone (DHT), progesterone, 17-hydroxyprogesterone, allopregnanolone, estrone, estradiol, sex hormone binding globulin (SHBG), cortisol, follicle stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were evaluated monthly to assess the endocrine effects of the therapy, while beta-endorphin values were used as a marker of the neuroendocrine effects. A Kupperman questionnaire was performed to evaluate the subjective symptoms before and after treatment. The results showed a great modification of the endocrine profile; with the exception of cortisol levels, which remained unchanged, DHEA, DHEAS, androstenedione, total and free testosterone, DHT, progesterone, 17-hydroxyprogesterone, estrone, estradiol, GH, IGF-1 and beta-endorphin levels increased significantly with respect to baseline values, while FSH, LH and SHBG levels showed a significant decrease. The Kupperman score indicated a progressive improvement in mood, fatigue and joint pain. In conclusion, the present study demonstrates that 25 mg/day of DHEA is able to cause significant changes in the hormonal profile and clinical symptoms and can counteract the age-related decline of endocrine and neuroendocrine functions. Restoring DHEA levels to young adult values seems to benefit the age-related decline in physiological functions but, however promising, placebo-controlled trials are required to confirm these preliminary results. SN - 1368-5538 UR - https://www.unboundmedicine.com/medline/citation/15672938/Long_term_low_dose_dehydroepiandrosterone_replacement_therapy_in_aging_males_with_partial_androgen_deficiency_ L2 - https://www.tandfonline.com/doi/full/10.1080/13685530412331284669 DB - PRIME DP - Unbound Medicine ER -