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Phenolic extractives from the bark of Pinus sylvestris L. and their effects on inflammatory mediators nitric oxide and prostaglandin E2.
J Agric Food Chem. 2004 Dec 15; 52(25):7532-40.JA

Abstract

The anti-inflammatory properties of phenolic pine (Pinus sylvestris L.) bark extract were studied. The pine bark extract was fractionated by liquid-liquid extractions and semipreparative high-performance liquid chromatography to reveal the most potent constituents. The phenolic compositions of three pine bark samples obtained, a crude extract, a chloroform fraction, and a semipreparative fraction, were analyzed using high-performance liquid chromatography with UV diode array detection and/or electrospray ionization mass spectrometry. In addition, eight compounds were isolated and identified by NMR and MS techniques. In total 28 phenolic compounds were identified. The effects of the three pine bark samples on the synthesis of two proinflammatory mediators, nitric oxide and prostaglandin E(2), were measured. It was shown that pine bark contains compounds that inhibit the production of these proinflammatory mediators.

Authors+Show Affiliations

Environmental Chemistry and Structural Chemistry Group, Department of Chemistry, University of Turku, Vatselankatu 2, FIN-20014 Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15675800

Citation

Karonen, Maarit, et al. "Phenolic Extractives From the Bark of Pinus Sylvestris L. and Their Effects On Inflammatory Mediators Nitric Oxide and Prostaglandin E2." Journal of Agricultural and Food Chemistry, vol. 52, no. 25, 2004, pp. 7532-40.
Karonen M, Hämäläinen M, Nieminen R, et al. Phenolic extractives from the bark of Pinus sylvestris L. and their effects on inflammatory mediators nitric oxide and prostaglandin E2. J Agric Food Chem. 2004;52(25):7532-40.
Karonen, M., Hämäläinen, M., Nieminen, R., Klika, K. D., Loponen, J., Ovcharenko, V. V., Moilanen, E., & Pihlaja, K. (2004). Phenolic extractives from the bark of Pinus sylvestris L. and their effects on inflammatory mediators nitric oxide and prostaglandin E2. Journal of Agricultural and Food Chemistry, 52(25), 7532-40.
Karonen M, et al. Phenolic Extractives From the Bark of Pinus Sylvestris L. and Their Effects On Inflammatory Mediators Nitric Oxide and Prostaglandin E2. J Agric Food Chem. 2004 Dec 15;52(25):7532-40. PubMed PMID: 15675800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic extractives from the bark of Pinus sylvestris L. and their effects on inflammatory mediators nitric oxide and prostaglandin E2. AU - Karonen,Maarit, AU - Hämäläinen,Mari, AU - Nieminen,Riina, AU - Klika,Karel D, AU - Loponen,Jyrki, AU - Ovcharenko,Vladimir V, AU - Moilanen,Eeva, AU - Pihlaja,Kalevi, PY - 2005/1/29/pubmed PY - 2005/4/21/medline PY - 2005/1/29/entrez SP - 7532 EP - 40 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 52 IS - 25 N2 - The anti-inflammatory properties of phenolic pine (Pinus sylvestris L.) bark extract were studied. The pine bark extract was fractionated by liquid-liquid extractions and semipreparative high-performance liquid chromatography to reveal the most potent constituents. The phenolic compositions of three pine bark samples obtained, a crude extract, a chloroform fraction, and a semipreparative fraction, were analyzed using high-performance liquid chromatography with UV diode array detection and/or electrospray ionization mass spectrometry. In addition, eight compounds were isolated and identified by NMR and MS techniques. In total 28 phenolic compounds were identified. The effects of the three pine bark samples on the synthesis of two proinflammatory mediators, nitric oxide and prostaglandin E(2), were measured. It was shown that pine bark contains compounds that inhibit the production of these proinflammatory mediators. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15675800/Phenolic_extractives_from_the_bark_of_Pinus_sylvestris_L__and_their_effects_on_inflammatory_mediators_nitric_oxide_and_prostaglandin_E2_ L2 - https://doi.org/10.1021/jf048948q DB - PRIME DP - Unbound Medicine ER -