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A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma.
Br J Clin Pharmacol. 2005 Feb; 59(2):152-9.BJ

Abstract

AIMS

We have compared the ability of plethysmography (sGaw), impulse oscillometry (IOS) and spirometry (FEV(1), MMEF) to detect bronchodilation in response to an anticholinergic.

METHODS

IOS (R5, R20, X5, RF), sGaw and spirometry were measured in 12 healthy subjects and 12 asthmatics. Variability was assessed by performing two measurements, 30 min apart and the effect of increasing the number of readings for each sGaw measurement was also studied. Ipratropium bromide (IB) 10, 20, 100 and 200 microg was administered and the sensitivity of the methods compared by determining the lowest dose that caused changes greater than variability.

RESULTS

In healthy subjects significant changes (P < or = 0.05) occurred at 10 microg for FEV(1) (mean [95% CI]; 1.3%[0.3-2.3]), R5 (mean [95% CI]; -7.9%, [-13.2-2.6]) and R20 (mean [95% CI], -6.4%, [-11.4-1.4]). No significant change was detected when the mean of 3 sGaw readings was used, but with 10 readings significant change was observed at 20 microg; (mean increase [95% CI] 15.2%[8.3-22.1]). In asthmatics significant changes (P < or = 0.05) occurred with IB 10 microg for sGaw (mean [95% CI] 25.6%[11.1-40.1]), R5 (mean [95% CI]-11.3%, [-15.5-7.2]), RF (mean [95% CI] 11.7%[6.1-16.3]), FEV(1) (mean [95% CI] 5.1%[2.6-7.7]) and MMEF (mean [95% CI] 12.3%[2.3-22.2]).

CONCLUSION

IOS and spirometry are more sensitive than sGaw in healthy subjects, but the sensitivity of sGaw improved when the number of readings was increased. The most sensitive method for assessing bronchodilation in asthmatics was sGaw.

Authors+Show Affiliations

Medicines Evaluation Unit, North-west Lung Research Centre, Wythenshawe Hospital, Manchester, UK. cathhoughton@doctors.org.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15676036

Citation

Houghton, C M., et al. "A Comparison of Plethysmography, Spirometry and Oscillometry for Assessing the Pulmonary Effects of Inhaled Ipratropium Bromide in Healthy Subjects and Patients With Asthma." British Journal of Clinical Pharmacology, vol. 59, no. 2, 2005, pp. 152-9.
Houghton CM, Woodcock AA, Singh D. A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. Br J Clin Pharmacol. 2005;59(2):152-9.
Houghton, C. M., Woodcock, A. A., & Singh, D. (2005). A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. British Journal of Clinical Pharmacology, 59(2), 152-9.
Houghton CM, Woodcock AA, Singh D. A Comparison of Plethysmography, Spirometry and Oscillometry for Assessing the Pulmonary Effects of Inhaled Ipratropium Bromide in Healthy Subjects and Patients With Asthma. Br J Clin Pharmacol. 2005;59(2):152-9. PubMed PMID: 15676036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. AU - Houghton,C M, AU - Woodcock,A A, AU - Singh,D, PY - 2005/1/29/pubmed PY - 2005/5/26/medline PY - 2005/1/29/entrez SP - 152 EP - 9 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 59 IS - 2 N2 - AIMS: We have compared the ability of plethysmography (sGaw), impulse oscillometry (IOS) and spirometry (FEV(1), MMEF) to detect bronchodilation in response to an anticholinergic. METHODS: IOS (R5, R20, X5, RF), sGaw and spirometry were measured in 12 healthy subjects and 12 asthmatics. Variability was assessed by performing two measurements, 30 min apart and the effect of increasing the number of readings for each sGaw measurement was also studied. Ipratropium bromide (IB) 10, 20, 100 and 200 microg was administered and the sensitivity of the methods compared by determining the lowest dose that caused changes greater than variability. RESULTS: In healthy subjects significant changes (P < or = 0.05) occurred at 10 microg for FEV(1) (mean [95% CI]; 1.3%[0.3-2.3]), R5 (mean [95% CI]; -7.9%, [-13.2-2.6]) and R20 (mean [95% CI], -6.4%, [-11.4-1.4]). No significant change was detected when the mean of 3 sGaw readings was used, but with 10 readings significant change was observed at 20 microg; (mean increase [95% CI] 15.2%[8.3-22.1]). In asthmatics significant changes (P < or = 0.05) occurred with IB 10 microg for sGaw (mean [95% CI] 25.6%[11.1-40.1]), R5 (mean [95% CI]-11.3%, [-15.5-7.2]), RF (mean [95% CI] 11.7%[6.1-16.3]), FEV(1) (mean [95% CI] 5.1%[2.6-7.7]) and MMEF (mean [95% CI] 12.3%[2.3-22.2]). CONCLUSION: IOS and spirometry are more sensitive than sGaw in healthy subjects, but the sensitivity of sGaw improved when the number of readings was increased. The most sensitive method for assessing bronchodilation in asthmatics was sGaw. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/15676036/A_comparison_of_plethysmography_spirometry_and_oscillometry_for_assessing_the_pulmonary_effects_of_inhaled_ipratropium_bromide_in_healthy_subjects_and_patients_with_asthma_ L2 - https://doi.org/10.1111/j.1365-2125.2004.2262.x DB - PRIME DP - Unbound Medicine ER -