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Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension.
Int J Cardiol. 2005 Jan; 98(1):39-44.IJ

Abstract

BACKGROUND

Risk factors for atherosclerosis such as hypertension, type 2 diabetes, obesity and dyslipidemia affect endothelial function and stimulate adhesion molecules expression. The aim of the study was to examine endothelial activation in type 2 diabetes and hypertension as indicated by adhesion molecule levels and further to investigate whether the coexistence of the above conditions has a different effect.

METHODS

Serum levels of soluble E-selectin, ICAM-1 and VCAM-1 were measured in 17 hypertensive type 2 diabetic patients (DM-HY), 32 normotensive type 2 diabetic patients (DM), 11 hypertensive nondiabetic patients (HY) and 15 healthy subjects.

RESULTS

In diabetic patients (either DM-HY or DM), soluble E-selectin levels were significantly increased compared to healthy subjects (p<0.001). In HY patients, both sE-selectin (66.44+/-71.59 vs. 29.42+/-15.56 ng/ml, p=0.033) and sVCAM-1 (1529+/-433.33 vs. 1027+/-243.56 ng/ml, p=0.03) levels were found significantly higher compared to healthy subjects (p<0.05). The coexistence of diabetes and hypertension (DM-HY) did not have an additive effect on circulating adhesion molecules levels compared with the levels observed in either diabetes or hypertension. Systolic and diastolic blood pressure (BP) were independent factors correlated respectively with sE-selectin and sVCAM-1 levels (R=0.454, p=0.034 and R=0.578, p=0.005) in nondiabetic subjects (hypertensive and normotensive).

CONCLUSIONS

Type 2 diabetes mellitus and hypertension induce endothelial activation as indicated by elevated levels of soluble adhesion molecules. This effect is not different when comorbidity is present.

Authors+Show Affiliations

Department of Physiology, Medical School, University of Thessaly, 22 Papakyriazi, 41222 Larissa, Greece. mboul@med.uth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15676164

Citation

Boulbou, Mary S., et al. "Circulating Adhesion Molecules Levels in Type 2 Diabetes Mellitus and Hypertension." International Journal of Cardiology, vol. 98, no. 1, 2005, pp. 39-44.
Boulbou MS, Koukoulis GN, Makri ED, et al. Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. Int J Cardiol. 2005;98(1):39-44.
Boulbou, M. S., Koukoulis, G. N., Makri, E. D., Petinaki, E. A., Gourgoulianis, K. I., & Germenis, A. E. (2005). Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. International Journal of Cardiology, 98(1), 39-44.
Boulbou MS, et al. Circulating Adhesion Molecules Levels in Type 2 Diabetes Mellitus and Hypertension. Int J Cardiol. 2005;98(1):39-44. PubMed PMID: 15676164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. AU - Boulbou,Mary S, AU - Koukoulis,George N, AU - Makri,Erini D, AU - Petinaki,Efthymia A, AU - Gourgoulianis,Konstantinos I, AU - Germenis,Anastasios E, PY - 2003/04/11/received PY - 2003/07/14/revised PY - 2003/07/25/accepted PY - 2005/1/29/pubmed PY - 2006/8/23/medline PY - 2005/1/29/entrez SP - 39 EP - 44 JF - International journal of cardiology JO - Int J Cardiol VL - 98 IS - 1 N2 - BACKGROUND: Risk factors for atherosclerosis such as hypertension, type 2 diabetes, obesity and dyslipidemia affect endothelial function and stimulate adhesion molecules expression. The aim of the study was to examine endothelial activation in type 2 diabetes and hypertension as indicated by adhesion molecule levels and further to investigate whether the coexistence of the above conditions has a different effect. METHODS: Serum levels of soluble E-selectin, ICAM-1 and VCAM-1 were measured in 17 hypertensive type 2 diabetic patients (DM-HY), 32 normotensive type 2 diabetic patients (DM), 11 hypertensive nondiabetic patients (HY) and 15 healthy subjects. RESULTS: In diabetic patients (either DM-HY or DM), soluble E-selectin levels were significantly increased compared to healthy subjects (p<0.001). In HY patients, both sE-selectin (66.44+/-71.59 vs. 29.42+/-15.56 ng/ml, p=0.033) and sVCAM-1 (1529+/-433.33 vs. 1027+/-243.56 ng/ml, p=0.03) levels were found significantly higher compared to healthy subjects (p<0.05). The coexistence of diabetes and hypertension (DM-HY) did not have an additive effect on circulating adhesion molecules levels compared with the levels observed in either diabetes or hypertension. Systolic and diastolic blood pressure (BP) were independent factors correlated respectively with sE-selectin and sVCAM-1 levels (R=0.454, p=0.034 and R=0.578, p=0.005) in nondiabetic subjects (hypertensive and normotensive). CONCLUSIONS: Type 2 diabetes mellitus and hypertension induce endothelial activation as indicated by elevated levels of soluble adhesion molecules. This effect is not different when comorbidity is present. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15676164/Circulating_adhesion_molecules_levels_in_type_2_diabetes_mellitus_and_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167527303006107 DB - PRIME DP - Unbound Medicine ER -