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Mirtazapine acutely inhibits salivary cortisol concentrations in depressed patients.
Ann N Y Acad Sci. 2004 Dec; 1032:279-82.AN

Abstract

Mirtazapine has been shown to acutely inhibit cortisol secretion in healthy subjects. In the current study, the impact of mirtazapine treatment on salivary cortisol secretion was investigated in 12 patients with major depression (DSM-IV criteria). Patients were treated with mirtazapine for 3 weeks, receiving 15 mg of mirtazapine on day 0, 30 mg on day 1, and 45 mg per day from day 2 to the end of the study (day 21). Response to mirtazapine treatment was defined by a reduction of at least 50% in the Hamilton Rating Scale for Depression after 3 weeks of therapy. Salivary cortisol concentrations were measured before treatment (day -1), at the beginning of treatment (day 0), after 1 week (day 7), and after 3 weeks (day 21) of treatment with mirtazapine. Saliva samples were collected hourly from 8 am to 8 pm. A significant reduction in cortisol concentrations was already noted after 1 day of mirtazapine treatment which was comparable in responders and in nonresponders. Mirtazapine therefore appears to be an effective in decreasing hypercortisolism in depression. However, the importance of the acute inhibitory effects of mirtazapine on cortisol secretion for its antidepressant efficacy has to be further clarified.

Authors+Show Affiliations

Department of Psychiatry, University of Munich, Nussbaumstr. 7, 80336 Munich, Germany. Prof.Laakmann@psy.med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15677428

Citation

Laakmann, Gregor, et al. "Mirtazapine Acutely Inhibits Salivary Cortisol Concentrations in Depressed Patients." Annals of the New York Academy of Sciences, vol. 1032, 2004, pp. 279-82.
Laakmann G, Hennig J, Baghai T, et al. Mirtazapine acutely inhibits salivary cortisol concentrations in depressed patients. Ann N Y Acad Sci. 2004;1032:279-82.
Laakmann, G., Hennig, J., Baghai, T., & Schüle, C. (2004). Mirtazapine acutely inhibits salivary cortisol concentrations in depressed patients. Annals of the New York Academy of Sciences, 1032, 279-82.
Laakmann G, et al. Mirtazapine Acutely Inhibits Salivary Cortisol Concentrations in Depressed Patients. Ann N Y Acad Sci. 2004;1032:279-82. PubMed PMID: 15677428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mirtazapine acutely inhibits salivary cortisol concentrations in depressed patients. AU - Laakmann,Gregor, AU - Hennig,Jürgen, AU - Baghai,Thomas, AU - Schüle,Cornelius, PY - 2005/1/29/pubmed PY - 2005/4/20/medline PY - 2005/1/29/entrez SP - 279 EP - 82 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1032 N2 - Mirtazapine has been shown to acutely inhibit cortisol secretion in healthy subjects. In the current study, the impact of mirtazapine treatment on salivary cortisol secretion was investigated in 12 patients with major depression (DSM-IV criteria). Patients were treated with mirtazapine for 3 weeks, receiving 15 mg of mirtazapine on day 0, 30 mg on day 1, and 45 mg per day from day 2 to the end of the study (day 21). Response to mirtazapine treatment was defined by a reduction of at least 50% in the Hamilton Rating Scale for Depression after 3 weeks of therapy. Salivary cortisol concentrations were measured before treatment (day -1), at the beginning of treatment (day 0), after 1 week (day 7), and after 3 weeks (day 21) of treatment with mirtazapine. Saliva samples were collected hourly from 8 am to 8 pm. A significant reduction in cortisol concentrations was already noted after 1 day of mirtazapine treatment which was comparable in responders and in nonresponders. Mirtazapine therefore appears to be an effective in decreasing hypercortisolism in depression. However, the importance of the acute inhibitory effects of mirtazapine on cortisol secretion for its antidepressant efficacy has to be further clarified. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15677428/Mirtazapine_acutely_inhibits_salivary_cortisol_concentrations_in_depressed_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1032&spage=279 DB - PRIME DP - Unbound Medicine ER -