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Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
Ann N Y Acad Sci. 2004 Dec; 1032:287-8.AN

Abstract

Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone.

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Authors+Show Affiliations

Joffe RT
Department of Psychiatry, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA. joffe@umdnj.edu
Sawka AM
No affiliation info available
Marriott MJ
No affiliation info available
MacQueen GM
No affiliation info available
Gernstein HC
No affiliation info available

MeSH

AdultAgedDepressive DisorderDrug Therapy, CombinationFemaleHormone Replacement TherapyHumansHypothyroidismMaleMiddle AgedPsychiatric Status Rating ScalesThyrotropinThyroxineTriiodothyronine

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15677430

Citation

Joffe, Russell T., et al. "Does Substitution of T4 With T3 Plus T4 for T4 Replacement Improve Depressive Symptoms in Patients With Hypothyroidism?" Annals of the New York Academy of Sciences, vol. 1032, 2004, pp. 287-8.
Joffe RT, Sawka AM, Marriott MJ, et al. Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism? Ann N Y Acad Sci. 2004;1032:287-8.
Joffe, R. T., Sawka, A. M., Marriott, M. J., MacQueen, G. M., & Gernstein, H. C. (2004). Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism? Annals of the New York Academy of Sciences, 1032, 287-8.
Joffe RT, et al. Does Substitution of T4 With T3 Plus T4 for T4 Replacement Improve Depressive Symptoms in Patients With Hypothyroidism. Ann N Y Acad Sci. 2004;1032:287-8. PubMed PMID: 15677430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism? AU - Joffe,Russell T, AU - Sawka,Anna M, AU - Marriott,Michael J, AU - MacQueen,Glenda M, AU - Gernstein,Hertzl C, PY - 2005/1/29/pubmed PY - 2005/4/20/medline PY - 2005/1/29/entrez SP - 287 EP - 8 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1032 N2 - Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15677430/Does_substitution_of_T4_with_T3_plus_T4_for_T4_replacement_improve_depressive_symptoms_in_patients_with_hypothyroidism L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1032&spage=287 DB - PRIME DP - Unbound Medicine ER -