Tags

Type your tag names separated by a space and hit enter

Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan.

Abstract

To evaluate the role of dietary factors in the etiology of inflammatory bowel disease (IBD), we conducted a multicenter hospital-based case-control study in a Japanese population. Cases were IBD patients aged 15 to 34 years [ulcerative colitis (UC) 111 patients; Crohn's disease (CD) 128 patients] within 3 years after diagnosis in 13 hospitals. One control subject was recruited for each case who was matched for sex, age, and hospital. A semiquantitative food frequency questionnaire was used to estimate preillness intakes of food groups and nutrients. All the available control subjects (n = 219) were pooled, and unconditional logistic models were applied to calculate odds ratios (ORs). In the food groups, a higher consumption of sweets was positively associated with UC risk [OR for the highest versus lowest quartile, 2.86; 95% confidence interval (CI), 1.24 to 6.57], whereas the consumption of sugars and sweeteners (OR, 2.12; 95% CI, 1.08 to 4.17), sweets (OR, 2.83; 95% CI, 1.38 to 5.83), fats and oils (OR, 2.64; 95% CI, 1.29 to 5.39), and fish and shellfish (OR, 2.41; 95% CI, 1.18-4.89) were positively associated with CD risk. In respect to nutrients, the intake of vitamin C (OR, 0.45; 95% CI, 0.21 to 0.99) was negatively related to UC risk, while the intake of total fat (OR, 2.86; 95% CI, 1.39 to 5.90), monounsaturated fatty acids (OR, 2.49; 95% CI, 1.23 to 5.03) and polyunsaturated fatty acids (OR, 2.31; 95% CI, 1.12 to 4.79), vitamin E (OR, 3.23; 95% CI, 1.45 to 7.17), and n-3 (OR, 3.24; 95% CI, 1.52 to 6.88) and n-6 fatty acids (OR, 2.57; 95% CI, 1.24 to 5.32) was positively associated with CD risk. Although this study suffers from the shortcoming of recall bias, which is inherent in most retrospective studies (prospective studies are warranted to confirm the associations between diet and IBD risk), the present findings suggest the importance of dietary factors for IBD prevention.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Hygiene, Hyogo College of Medicine, Hyogo, Japan. naomasas@hyo-med.ac.jp

    , , , , , , , , , , , , , ,

    Source

    Inflammatory bowel diseases 11:2 2005 Feb pg 154-63

    MeSH

    Adolescent
    Adult
    Ascorbic Acid
    Case-Control Studies
    Colitis, Ulcerative
    Crohn Disease
    Diet
    Dietary Fats
    Dietary Sucrose
    Female
    Humans
    Japan
    Male
    Mental Recall
    Odds Ratio
    Reproducibility of Results
    Risk Factors
    Seafood

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15677909

    Citation

    Sakamoto, Naomasa, et al. "Dietary Risk Factors for Inflammatory Bowel Disease: a Multicenter Case-control Study in Japan." Inflammatory Bowel Diseases, vol. 11, no. 2, 2005, pp. 154-63.
    Sakamoto N, Kono S, Wakai K, et al. Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis. 2005;11(2):154-63.
    Sakamoto, N., Kono, S., Wakai, K., Fukuda, Y., Satomi, M., Shimoyama, T., ... Tanaka, H. (2005). Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflammatory Bowel Diseases, 11(2), pp. 154-63.
    Sakamoto N, et al. Dietary Risk Factors for Inflammatory Bowel Disease: a Multicenter Case-control Study in Japan. Inflamm Bowel Dis. 2005;11(2):154-63. PubMed PMID: 15677909.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. AU - Sakamoto,Naomasa, AU - Kono,Suminori, AU - Wakai,Kenji, AU - Fukuda,Yoshihiro, AU - Satomi,Masamichi, AU - Shimoyama,Takashi, AU - Inaba,Yutaka, AU - Miyake,Yoshihiro, AU - Sasaki,Satoshi, AU - Okamoto,Kazushi, AU - Kobashi,Gen, AU - Washio,Masakazu, AU - Yokoyama,Tetsuji, AU - Date,Chigusa, AU - Tanaka,Heizo, AU - ,, PY - 2005/1/29/pubmed PY - 2005/5/13/medline PY - 2005/1/29/entrez SP - 154 EP - 63 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 11 IS - 2 N2 - To evaluate the role of dietary factors in the etiology of inflammatory bowel disease (IBD), we conducted a multicenter hospital-based case-control study in a Japanese population. Cases were IBD patients aged 15 to 34 years [ulcerative colitis (UC) 111 patients; Crohn's disease (CD) 128 patients] within 3 years after diagnosis in 13 hospitals. One control subject was recruited for each case who was matched for sex, age, and hospital. A semiquantitative food frequency questionnaire was used to estimate preillness intakes of food groups and nutrients. All the available control subjects (n = 219) were pooled, and unconditional logistic models were applied to calculate odds ratios (ORs). In the food groups, a higher consumption of sweets was positively associated with UC risk [OR for the highest versus lowest quartile, 2.86; 95% confidence interval (CI), 1.24 to 6.57], whereas the consumption of sugars and sweeteners (OR, 2.12; 95% CI, 1.08 to 4.17), sweets (OR, 2.83; 95% CI, 1.38 to 5.83), fats and oils (OR, 2.64; 95% CI, 1.29 to 5.39), and fish and shellfish (OR, 2.41; 95% CI, 1.18-4.89) were positively associated with CD risk. In respect to nutrients, the intake of vitamin C (OR, 0.45; 95% CI, 0.21 to 0.99) was negatively related to UC risk, while the intake of total fat (OR, 2.86; 95% CI, 1.39 to 5.90), monounsaturated fatty acids (OR, 2.49; 95% CI, 1.23 to 5.03) and polyunsaturated fatty acids (OR, 2.31; 95% CI, 1.12 to 4.79), vitamin E (OR, 3.23; 95% CI, 1.45 to 7.17), and n-3 (OR, 3.24; 95% CI, 1.52 to 6.88) and n-6 fatty acids (OR, 2.57; 95% CI, 1.24 to 5.32) was positively associated with CD risk. Although this study suffers from the shortcoming of recall bias, which is inherent in most retrospective studies (prospective studies are warranted to confirm the associations between diet and IBD risk), the present findings suggest the importance of dietary factors for IBD prevention. SN - 1078-0998 UR - https://www.unboundmedicine.com/medline/citation/15677909/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=15677909 DB - PRIME DP - Unbound Medicine ER -