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Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucoflavones from Lychnophora ericoides (Asteraceae).
Planta Med. 2005 Jan; 71(1):3-6.PM

Abstract

The Brazilian medicinal plant Lychnophora ericoides is commercially available as an analgesic and anti-inflammatory agent. The phytochemical investigation of the leaf polar extract yielded 6,8-di-C-beta-glucosylapigenin (1) and the new compound 6,8-di-C-beta-glucosylchrysin (2). 6,8-Di- C-beta-glucosylapigenin (1) showed significant anti-inflammatory activity in the carrageenan-induced rat paw edema. We did not observe any statistical difference between the two compounds (1 and 2) in inhibiting chemiluminescence in opsonized zymosan-stimulated polymorphonuclear leukocytes, suggesting that the anti-inflammatory property of 6,8-di- C-beta-glucosylapigenin (1) is not related to its antioxidant activity.

Authors+Show Affiliations

Gobbo-Neto L
Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP, Ribeirão Preto, São Paulo, Brazil.
Santos MD
No affiliation info available
Kanashiro A
No affiliation info available
Almeida MC
No affiliation info available
Lucisano-Valim YM
No affiliation info available
Lopes JL
No affiliation info available
Souza GE
No affiliation info available
Lopes NP
No affiliation info available

MeSH

Administration, OralAnimalsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsAsteraceaeCarrageenanDose-Response Relationship, DrugEdemaLeukocytes, MononuclearMalePhytotherapyPlant ExtractsPlant LeavesRabbitsRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15678365

Citation

Gobbo-Neto, Leonardo, et al. "Evaluation of the Anti-inflammatory and Antioxidant Activities of di-C-glucoflavones From Lychnophora Ericoides (Asteraceae)." Planta Medica, vol. 71, no. 1, 2005, pp. 3-6.
Gobbo-Neto L, Santos MD, Kanashiro A, et al. Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucoflavones from Lychnophora ericoides (Asteraceae). Planta Med. 2005;71(1):3-6.
Gobbo-Neto, L., Santos, M. D., Kanashiro, A., Almeida, M. C., Lucisano-Valim, Y. M., Lopes, J. L., Souza, G. E., & Lopes, N. P. (2005). Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucoflavones from Lychnophora ericoides (Asteraceae). Planta Medica, 71(1), 3-6.
Gobbo-Neto L, et al. Evaluation of the Anti-inflammatory and Antioxidant Activities of di-C-glucoflavones From Lychnophora Ericoides (Asteraceae). Planta Med. 2005;71(1):3-6. PubMed PMID: 15678365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the anti-inflammatory and antioxidant activities of di-C-glucoflavones from Lychnophora ericoides (Asteraceae). AU - Gobbo-Neto,Leonardo, AU - Santos,Michel D, AU - Kanashiro,Alexandre, AU - Almeida,Maria C, AU - Lucisano-Valim,Yara M, AU - Lopes,João L, AU - Souza,Glória E, AU - Lopes,Norberto P, PY - 2005/1/29/pubmed PY - 2005/3/30/medline PY - 2005/1/29/entrez SP - 3 EP - 6 JF - Planta medica JO - Planta Med VL - 71 IS - 1 N2 - The Brazilian medicinal plant Lychnophora ericoides is commercially available as an analgesic and anti-inflammatory agent. The phytochemical investigation of the leaf polar extract yielded 6,8-di-C-beta-glucosylapigenin (1) and the new compound 6,8-di-C-beta-glucosylchrysin (2). 6,8-Di- C-beta-glucosylapigenin (1) showed significant anti-inflammatory activity in the carrageenan-induced rat paw edema. We did not observe any statistical difference between the two compounds (1 and 2) in inhibiting chemiluminescence in opsonized zymosan-stimulated polymorphonuclear leukocytes, suggesting that the anti-inflammatory property of 6,8-di- C-beta-glucosylapigenin (1) is not related to its antioxidant activity. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/15678365/Evaluation_of_the_anti_inflammatory_and_antioxidant_activities_of_di_C_glucoflavones_from_Lychnophora_ericoides__Asteraceae__ DB - PRIME DP - Unbound Medicine ER -