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Vitamin B12, folate, homocysteine and dementia: are they really related?
Arch Gerontol Geriatr. 2005 Mar-Apr; 40(2):139-46.AG

Abstract

Dementia is an acquired impairment of intellectual and memory functioning. There are numerous factors affecting neurocognitive functions like vascular factors, Vitamin B12 and folate and homocysteine levels. The aim of this study is to determine whether there is a relationship between the serum levels of these metabolites and diagnosis of dementia and mild cognitive impairment (MCI). A total of 1249 patients admitted to Hacettepe University Hospital Department of Internal Medicine, Division of Geriatric Medicine Outpatient Clinic between 1 February 2002 and 30 June 2003 were included in this study. Vitamin B12, folate and homocysteine levels were measured in all patients, and they were evaluated also for their cognitive abilities. In this study pool, 121 cases were diagnosed as Alzheimer's disease (AD), 60 patients were diagnosed as having non-Alzheimer dementia (NAD), 273 had MCI. When patients with AD, NAD, MCI and patients without dementia were compared according to their median values of folate, Vitamin B12 and homocysteine, there were no significant differences. Results of studies searching for a correlation between Vitamin B12, folate and homocysteine levels and their relation with cognitive status of the elderly are controversial in various studies from different countries. In this study (with 1249 elderly patients) we were unable to find any correlation between homocysteine, Vitamin B12 and folate levels and cognitive functioning in contrast with some literary data. Nevertheless, these metabolites should be measured routinely in the examination of any elderly patient, since they can play important roles in geriatric patients.

Authors+Show Affiliations

Department of Internal Medicine, Division of Geriatric Medicine, Medical Faculty, Hacettepe University, Sihhiye, 06100 Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15680498

Citation

Arioğul, Servet, et al. "Vitamin B12, Folate, Homocysteine and Dementia: Are They Really Related?" Archives of Gerontology and Geriatrics, vol. 40, no. 2, 2005, pp. 139-46.
Arioğul S, Cankurtaran M, Dağli N, et al. Vitamin B12, folate, homocysteine and dementia: are they really related? Arch Gerontol Geriatr. 2005;40(2):139-46.
Arioğul, S., Cankurtaran, M., Dağli, N., Khalil, M., & Yavuz, B. (2005). Vitamin B12, folate, homocysteine and dementia: are they really related? Archives of Gerontology and Geriatrics, 40(2), 139-46.
Arioğul S, et al. Vitamin B12, Folate, Homocysteine and Dementia: Are They Really Related. Arch Gerontol Geriatr. 2005 Mar-Apr;40(2):139-46. PubMed PMID: 15680498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12, folate, homocysteine and dementia: are they really related? AU - Arioğul,Servet, AU - Cankurtaran,Mustafa, AU - Dağli,Neslihan, AU - Khalil,Meltem, AU - Yavuz,Burcu, PY - 2004/02/17/received PY - 2004/07/22/revised PY - 2004/07/26/accepted PY - 2005/2/1/pubmed PY - 2005/7/15/medline PY - 2005/2/1/entrez SP - 139 EP - 46 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 40 IS - 2 N2 - Dementia is an acquired impairment of intellectual and memory functioning. There are numerous factors affecting neurocognitive functions like vascular factors, Vitamin B12 and folate and homocysteine levels. The aim of this study is to determine whether there is a relationship between the serum levels of these metabolites and diagnosis of dementia and mild cognitive impairment (MCI). A total of 1249 patients admitted to Hacettepe University Hospital Department of Internal Medicine, Division of Geriatric Medicine Outpatient Clinic between 1 February 2002 and 30 June 2003 were included in this study. Vitamin B12, folate and homocysteine levels were measured in all patients, and they were evaluated also for their cognitive abilities. In this study pool, 121 cases were diagnosed as Alzheimer's disease (AD), 60 patients were diagnosed as having non-Alzheimer dementia (NAD), 273 had MCI. When patients with AD, NAD, MCI and patients without dementia were compared according to their median values of folate, Vitamin B12 and homocysteine, there were no significant differences. Results of studies searching for a correlation between Vitamin B12, folate and homocysteine levels and their relation with cognitive status of the elderly are controversial in various studies from different countries. In this study (with 1249 elderly patients) we were unable to find any correlation between homocysteine, Vitamin B12 and folate levels and cognitive functioning in contrast with some literary data. Nevertheless, these metabolites should be measured routinely in the examination of any elderly patient, since they can play important roles in geriatric patients. SN - 0167-4943 UR - https://www.unboundmedicine.com/medline/citation/15680498/Vitamin_B12_folate_homocysteine_and_dementia:_are_they_really_related L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(04)00147-5 DB - PRIME DP - Unbound Medicine ER -