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Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction.
J Am Coll Cardiol. 2005 Feb 01; 45(3):391-9.JACC

Abstract

OBJECTIVES

We aimed to investigate the impact of angiotensin-converting enzyme inhibitors (ACEIs) on hematocrit values in those with heart failure, and the relationship between incident anemia and mortality.

BACKGROUND

Prevalent anemia is an independent risk factor for morbidity and mortality in those with heart failure. Studies in patients with polycythemia have demonstrated that ACEIs are effective in lowering hematocrit values.

METHODS

We used the Studies Of Left Ventricular Dysfunction (SOLVD) database to compare the odds of developing new anemia at one year in patients who were not anemic at entry and who were randomized to enalapril or placebo. Cox proportional hazards models were utilized to determine the impact of incident and prevalent anemia on subsequent mortality.

RESULTS

Enalapril increased the odds of incident anemia (hematocrit < or =39% in men or < or =36% in women) at one year by 48% (odds ratio [OR] 1.48, 95% confidence interval [CI] 1.20 to 1.82) in unadjusted and 56% (OR 1.56, 95% CI 1.26 to 1.93) in adjusted models. With multivariate analysis, prevalent anemia at randomization was associated with a 44% (hazard ratio [HR] 1.44, 95% CI 1.31 to 1.66) increase in all-cause mortality, whereas incident anemia after randomization was associated with a 108% increase (HR 2.08, 95% CI 1.82 to 2.38). After adjusting for incident and prevalent anemia, use of enalapril was associated with a survival benefit.

CONCLUSIONS

Enalapril was associated with increased odds of developing anemia at one year. Those with periods of time with incident anemia had the poorest survival, followed by those with prevalent anemia, then those without anemia. Enalapril was protective of overall mortality after adjusting for incident anemia and in those with prevalent anemia.

Authors+Show Affiliations

Section of Nephrology, Department of Medicine, Minneapolis VAMC, One Veterans Drive, Minneapolis, MN 55417, USA. isha0012@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15680718

Citation

Ishani, Areef, et al. "Angiotensin-converting Enzyme Inhibitor as a Risk Factor for the Development of Anemia, and the Impact of Incident Anemia On Mortality in Patients With Left Ventricular Dysfunction." Journal of the American College of Cardiology, vol. 45, no. 3, 2005, pp. 391-9.
Ishani A, Weinhandl E, Zhao Z, et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2005;45(3):391-9.
Ishani, A., Weinhandl, E., Zhao, Z., Gilbertson, D. T., Collins, A. J., Yusuf, S., & Herzog, C. A. (2005). Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. Journal of the American College of Cardiology, 45(3), 391-9.
Ishani A, et al. Angiotensin-converting Enzyme Inhibitor as a Risk Factor for the Development of Anemia, and the Impact of Incident Anemia On Mortality in Patients With Left Ventricular Dysfunction. J Am Coll Cardiol. 2005 Feb 1;45(3):391-9. PubMed PMID: 15680718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. AU - Ishani,Areef, AU - Weinhandl,Eric, AU - Zhao,Zihong, AU - Gilbertson,David T, AU - Collins,Allan J, AU - Yusuf,Salim, AU - Herzog,Charles A, PY - 2004/07/27/received PY - 2004/09/21/revised PY - 2004/10/04/accepted PY - 2005/2/1/pubmed PY - 2005/3/16/medline PY - 2005/2/1/entrez SP - 391 EP - 9 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 45 IS - 3 N2 - OBJECTIVES: We aimed to investigate the impact of angiotensin-converting enzyme inhibitors (ACEIs) on hematocrit values in those with heart failure, and the relationship between incident anemia and mortality. BACKGROUND: Prevalent anemia is an independent risk factor for morbidity and mortality in those with heart failure. Studies in patients with polycythemia have demonstrated that ACEIs are effective in lowering hematocrit values. METHODS: We used the Studies Of Left Ventricular Dysfunction (SOLVD) database to compare the odds of developing new anemia at one year in patients who were not anemic at entry and who were randomized to enalapril or placebo. Cox proportional hazards models were utilized to determine the impact of incident and prevalent anemia on subsequent mortality. RESULTS: Enalapril increased the odds of incident anemia (hematocrit < or =39% in men or < or =36% in women) at one year by 48% (odds ratio [OR] 1.48, 95% confidence interval [CI] 1.20 to 1.82) in unadjusted and 56% (OR 1.56, 95% CI 1.26 to 1.93) in adjusted models. With multivariate analysis, prevalent anemia at randomization was associated with a 44% (hazard ratio [HR] 1.44, 95% CI 1.31 to 1.66) increase in all-cause mortality, whereas incident anemia after randomization was associated with a 108% increase (HR 2.08, 95% CI 1.82 to 2.38). After adjusting for incident and prevalent anemia, use of enalapril was associated with a survival benefit. CONCLUSIONS: Enalapril was associated with increased odds of developing anemia at one year. Those with periods of time with incident anemia had the poorest survival, followed by those with prevalent anemia, then those without anemia. Enalapril was protective of overall mortality after adjusting for incident anemia and in those with prevalent anemia. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15680718/Angiotensin_converting_enzyme_inhibitor_as_a_risk_factor_for_the_development_of_anemia_and_the_impact_of_incident_anemia_on_mortality_in_patients_with_left_ventricular_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(04)02134-5 DB - PRIME DP - Unbound Medicine ER -