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Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates.
J Virol. 2005 Feb; 79(4):2620-5.JV

Abstract

Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.

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Authors+Show Affiliations

Wu D
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150001, China.
Tu C
No affiliation info available
Xin C
No affiliation info available
Xuan H
No affiliation info available
Meng Q
No affiliation info available
Liu Y
No affiliation info available
Yu Y
No affiliation info available
Guan Y
No affiliation info available
Jiang Y
No affiliation info available
Yin X
No affiliation info available
Crameri G
No affiliation info available
Wang M
No affiliation info available
Li C
No affiliation info available
Liu S
No affiliation info available
Liao M
No affiliation info available
Feng L
No affiliation info available
Xiang H
No affiliation info available
Sun J
No affiliation info available
Chen J
No affiliation info available
Sun Y
No affiliation info available
Gu S
No affiliation info available
Liu N
No affiliation info available
Fu D
No affiliation info available
Eaton BT
No affiliation info available
Wang LF
No affiliation info available
Kong X
No affiliation info available

MeSH

AnimalsCat DiseasesCatsDisease Models, AnimalDisease SusceptibilitySevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory SyndromeViverridae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15681462

Citation

Wu, Donglai, et al. "Civets Are Equally Susceptible to Experimental Infection By Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates." Journal of Virology, vol. 79, no. 4, 2005, pp. 2620-5.
Wu D, Tu C, Xin C, et al. Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. J Virol. 2005;79(4):2620-5.
Wu, D., Tu, C., Xin, C., Xuan, H., Meng, Q., Liu, Y., Yu, Y., Guan, Y., Jiang, Y., Yin, X., Crameri, G., Wang, M., Li, C., Liu, S., Liao, M., Feng, L., Xiang, H., Sun, J., Chen, J., ... Kong, X. (2005). Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. Journal of Virology, 79(4), 2620-5.
Wu D, et al. Civets Are Equally Susceptible to Experimental Infection By Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates. J Virol. 2005;79(4):2620-5. PubMed PMID: 15681462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. AU - Wu,Donglai, AU - Tu,Changchun, AU - Xin,Chaoan, AU - Xuan,Hua, AU - Meng,Qingwen, AU - Liu,Yonggang, AU - Yu,Yedong, AU - Guan,Yuntao, AU - Jiang,Yu, AU - Yin,Xunnan, AU - Crameri,Gary, AU - Wang,Muping, AU - Li,Changwen, AU - Liu,Shengwang, AU - Liao,Ming, AU - Feng,Li, AU - Xiang,Hua, AU - Sun,Jinfu, AU - Chen,Jinding, AU - Sun,Yanwei, AU - Gu,Shoulin, AU - Liu,Nihong, AU - Fu,Dexia, AU - Eaton,Bryan T, AU - Wang,Lin-Fa, AU - Kong,Xiangang, PY - 2005/2/1/pubmed PY - 2005/8/10/medline PY - 2005/2/1/entrez SP - 2620 EP - 5 JF - Journal of virology JO - J Virol VL - 79 IS - 4 N2 - Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets (Paguma larvata) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/15681462/Civets_are_equally_susceptible_to_experimental_infection_by_two_different_severe_acute_respiratory_syndrome_coronavirus_isolates_ DB - PRIME DP - Unbound Medicine ER -