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Melatonin relieves the neural oxidative burden that contributes to dementias.
Ann N Y Acad Sci. 2004 Dec; 1035:179-96.AN

Abstract

This report summarizes some of the many publications that document the beneficial actions of melatonin within the central nervous system. Of particular interest are the multiple functions of melatonin and its metabolites as ubiquitously acting direct free radical scavengers and indirect antioxidants. The fact that melatonin and the metabolic progeny that are formed when it scavenges toxic reactants are all effective in neutralizing destructive molecules greatly increases the efficacy of melatonin as a protection against by-products of oxygen and nitrogen that normally mutilate essential molecules. Of the large number of situations in which oxidative stress may be the cause of disease processes or debilitating conditions, the current review examines melatonin's protection within the central nervous system, particularly in experimental ischemia/reperfusion (stroke) injury, Alzheimer's disease, and parkinsonism. In each of these conditions, melatonin has been found to provide significant neural protection against both the morphophysiological damage and the biobehavioral consequences of these infirmities. The report concludes with the suggestion that melatonin, alone or in combination with other antioxidants, be considered for routine usage to potentially combat some of the neural ravages of aging.

Authors+Show Affiliations

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, 78229-3900, USA. reiter@uthscsa.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15681808

Citation

Reiter, Russel J., et al. "Melatonin Relieves the Neural Oxidative Burden That Contributes to Dementias." Annals of the New York Academy of Sciences, vol. 1035, 2004, pp. 179-96.
Reiter RJ, Tan DX, Pappolla MA. Melatonin relieves the neural oxidative burden that contributes to dementias. Ann N Y Acad Sci. 2004;1035:179-96.
Reiter, R. J., Tan, D. X., & Pappolla, M. A. (2004). Melatonin relieves the neural oxidative burden that contributes to dementias. Annals of the New York Academy of Sciences, 1035, 179-96.
Reiter RJ, Tan DX, Pappolla MA. Melatonin Relieves the Neural Oxidative Burden That Contributes to Dementias. Ann N Y Acad Sci. 2004;1035:179-96. PubMed PMID: 15681808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin relieves the neural oxidative burden that contributes to dementias. AU - Reiter,Russel J, AU - Tan,Dun-Xian, AU - Pappolla,Miguel A, PY - 2005/2/1/pubmed PY - 2006/7/14/medline PY - 2005/2/1/entrez SP - 179 EP - 96 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1035 N2 - This report summarizes some of the many publications that document the beneficial actions of melatonin within the central nervous system. Of particular interest are the multiple functions of melatonin and its metabolites as ubiquitously acting direct free radical scavengers and indirect antioxidants. The fact that melatonin and the metabolic progeny that are formed when it scavenges toxic reactants are all effective in neutralizing destructive molecules greatly increases the efficacy of melatonin as a protection against by-products of oxygen and nitrogen that normally mutilate essential molecules. Of the large number of situations in which oxidative stress may be the cause of disease processes or debilitating conditions, the current review examines melatonin's protection within the central nervous system, particularly in experimental ischemia/reperfusion (stroke) injury, Alzheimer's disease, and parkinsonism. In each of these conditions, melatonin has been found to provide significant neural protection against both the morphophysiological damage and the biobehavioral consequences of these infirmities. The report concludes with the suggestion that melatonin, alone or in combination with other antioxidants, be considered for routine usage to potentially combat some of the neural ravages of aging. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/15681808/Melatonin_relieves_the_neural_oxidative_burden_that_contributes_to_dementias_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=2004&volume=1035&spage=179 DB - PRIME DP - Unbound Medicine ER -