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Development and activation of regulatory T cells in the human fetus.
Eur J Immunol. 2005 Feb; 35(2):383-90.EJ

Abstract

There is an increasing amount of knowledge on the functional properties of regulatory T cells (Treg) in the adult immune system, but data on the generation and function of these cells during human embryonic development are scarce. In this study, we show that in the fetal thymus, double-positive cells initiate expression of CD25, GITR, CTLA4 and CD122 during their transition from the CD27- to the CD27+ stage. Moreover, CD4+CD25+ fetal thymocytes already have the potential to suppress proliferation of CD25- cells. After leaving the thymus, FoxP3+CD4+CD25+ Treg enter the fetal lymph nodes and spleen, where they acquire a primed/memory phenotype. A model is proposed for the development of human fetal Treg that encompasses two sequential maturation steps: initiation of a regulatory phenotype and suppressive activity in the thymus; and subsequent activation within the peripheral lymphoid organs. Upon activation, FoxP3+CD4+CD25+ Treg suppress potentially deleterious responses by autoreactive lymphocytes and maintain homeostasis within the developing fetus.

Authors+Show Affiliations

Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15682453

Citation

Cupedo, Tom, et al. "Development and Activation of Regulatory T Cells in the Human Fetus." European Journal of Immunology, vol. 35, no. 2, 2005, pp. 383-90.
Cupedo T, Nagasawa M, Weijer K, et al. Development and activation of regulatory T cells in the human fetus. Eur J Immunol. 2005;35(2):383-90.
Cupedo, T., Nagasawa, M., Weijer, K., Blom, B., & Spits, H. (2005). Development and activation of regulatory T cells in the human fetus. European Journal of Immunology, 35(2), 383-90.
Cupedo T, et al. Development and Activation of Regulatory T Cells in the Human Fetus. Eur J Immunol. 2005;35(2):383-90. PubMed PMID: 15682453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and activation of regulatory T cells in the human fetus. AU - Cupedo,Tom, AU - Nagasawa,Maho, AU - Weijer,Kees, AU - Blom,Bianca, AU - Spits,Hergen, PY - 2005/2/1/pubmed PY - 2005/3/30/medline PY - 2005/2/1/entrez SP - 383 EP - 90 JF - European journal of immunology JO - Eur J Immunol VL - 35 IS - 2 N2 - There is an increasing amount of knowledge on the functional properties of regulatory T cells (Treg) in the adult immune system, but data on the generation and function of these cells during human embryonic development are scarce. In this study, we show that in the fetal thymus, double-positive cells initiate expression of CD25, GITR, CTLA4 and CD122 during their transition from the CD27- to the CD27+ stage. Moreover, CD4+CD25+ fetal thymocytes already have the potential to suppress proliferation of CD25- cells. After leaving the thymus, FoxP3+CD4+CD25+ Treg enter the fetal lymph nodes and spleen, where they acquire a primed/memory phenotype. A model is proposed for the development of human fetal Treg that encompasses two sequential maturation steps: initiation of a regulatory phenotype and suppressive activity in the thymus; and subsequent activation within the peripheral lymphoid organs. Upon activation, FoxP3+CD4+CD25+ Treg suppress potentially deleterious responses by autoreactive lymphocytes and maintain homeostasis within the developing fetus. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/15682453/Development_and_activation_of_regulatory_T_cells_in_the_human_fetus_ L2 - https://doi.org/10.1002/eji.200425763 DB - PRIME DP - Unbound Medicine ER -