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Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses.
Vet J 2005; 169(1):65-74VJ

Abstract

The oxidant/antioxidant equilibrium of trained thoroughbred horses (n = 40) was assessed on three occasions during a period of three months under field conditions by blood antioxidant markers analysis, i.e. plasma ascorbic acid (AA), plasma antioxidant capacity of water-soluble components (ACW), whole blood (GSH) and oxidised (GSSG) glutathione, plasma alpha-tocopherol and beta-carotene, plasma antioxidant capacity of lipid-soluble components (ACL), red blood cell superoxide dismutase (SOD) and glutathione-peroxidase activity (GPx) and plasma trace-elements, i.e. selenium (Se), copper (Cu), zinc (Zn). A control group of ten horses receiving a placebo and an antioxidant group of 30 horses orally supplemented with an antioxidant mixture were randomly formed. An antioxidant imbalance was observed after three months in the control group, reflected by a significant decrease in GSH, SOD, GPx, Se (P < 0.05) and a significant increase in GSSG (P < 0.05). The antioxidant supplement prevented GPx and Se decrease and significantly increased ACW, alpha-tocopherol, beta-carotene and ACL (P < 0.05). Significant sex- or age-related differences were found for AA, ACW, alpha-tocopherol, SOD, GPx and Se, and there were significant correlations between ACW-AA, ACL-alpha-tocopherol, GPx-Se, CPK-Se, CPK-alpha-tocopherol and CPK-Cu. This field study has shown that trained thoroughbred horses undergo significant changes of several blood antioxidant markers and that oral antioxidant supplementation might partially counterbalance these changes by improving the hydrophilic, lipophilic and enzymatic antioxidant blood capacity.

Authors+Show Affiliations

Department for Functional Sciences, Faculty of Veterinary Medicine, University of Liège, Sart Tilman, Bât B42, B-4000 Liège, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15683765

Citation

de Moffarts, B, et al. "Effect of Oral Antioxidant Supplementation On Blood Antioxidant Status in Trained Thoroughbred Horses." Veterinary Journal (London, England : 1997), vol. 169, no. 1, 2005, pp. 65-74.
de Moffarts B, Kirschvink N, Art T, et al. Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses. Vet J. 2005;169(1):65-74.
de Moffarts, B., Kirschvink, N., Art, T., Pincemail, J., & Lekeux, P. (2005). Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses. Veterinary Journal (London, England : 1997), 169(1), pp. 65-74.
de Moffarts B, et al. Effect of Oral Antioxidant Supplementation On Blood Antioxidant Status in Trained Thoroughbred Horses. Vet J. 2005;169(1):65-74. PubMed PMID: 15683765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses. AU - de Moffarts,B, AU - Kirschvink,N, AU - Art,T, AU - Pincemail,J, AU - Lekeux,P, PY - 2003/12/24/accepted PY - 2005/2/3/pubmed PY - 2005/6/14/medline PY - 2005/2/3/entrez SP - 65 EP - 74 JF - Veterinary journal (London, England : 1997) JO - Vet. J. VL - 169 IS - 1 N2 - The oxidant/antioxidant equilibrium of trained thoroughbred horses (n = 40) was assessed on three occasions during a period of three months under field conditions by blood antioxidant markers analysis, i.e. plasma ascorbic acid (AA), plasma antioxidant capacity of water-soluble components (ACW), whole blood (GSH) and oxidised (GSSG) glutathione, plasma alpha-tocopherol and beta-carotene, plasma antioxidant capacity of lipid-soluble components (ACL), red blood cell superoxide dismutase (SOD) and glutathione-peroxidase activity (GPx) and plasma trace-elements, i.e. selenium (Se), copper (Cu), zinc (Zn). A control group of ten horses receiving a placebo and an antioxidant group of 30 horses orally supplemented with an antioxidant mixture were randomly formed. An antioxidant imbalance was observed after three months in the control group, reflected by a significant decrease in GSH, SOD, GPx, Se (P < 0.05) and a significant increase in GSSG (P < 0.05). The antioxidant supplement prevented GPx and Se decrease and significantly increased ACW, alpha-tocopherol, beta-carotene and ACL (P < 0.05). Significant sex- or age-related differences were found for AA, ACW, alpha-tocopherol, SOD, GPx and Se, and there were significant correlations between ACW-AA, ACL-alpha-tocopherol, GPx-Se, CPK-Se, CPK-alpha-tocopherol and CPK-Cu. This field study has shown that trained thoroughbred horses undergo significant changes of several blood antioxidant markers and that oral antioxidant supplementation might partially counterbalance these changes by improving the hydrophilic, lipophilic and enzymatic antioxidant blood capacity. SN - 1090-0233 UR - https://www.unboundmedicine.com/medline/citation/15683765/Effect_of_oral_antioxidant_supplementation_on_blood_antioxidant_status_in_trained_thoroughbred_horses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090023304000061 DB - PRIME DP - Unbound Medicine ER -