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Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha.
Int Immunopharmacol. 2005 Mar; 5(3):461-83.II

Abstract

Hypoxia-inducible factor (HIF)--an oxygen sensor? The HIF-oxygen sensing association type of dogma is, unequivocally, well anchored. But this is only one face of, at least, a double-sided coin. Current concepts charge HIF of taking sides with a yet not well-founded identity--an immunologic sensor and/or regulator. Or, is it really a sensor, put it more correctly, a key player in sensing mechanisms? The evolving association between HIF and immunity emanates from an established linkage that bonds oxidative stress and inflammation--notably the 'biologic response modifiers', or cytokines. HIF is a redox(y)-sensitive transcription factor, and so are cytokines. Recently, cytokines emerged as major regulators of HIF, under physiologic conditions extending the realm of hypoxia. Alternatively, can HIF, like the so infamous inflammatory transcription factor NF-(kappa)B, prove itself as a key player in the regulation of cytokines and, subsequently, the inflammatory process. The targeting of HIF would be, at least theoretically, of therapeutic value, but does it make sense given its intricate role in hypoxia signaling? It is the theme of HIF being an immunologic sensor that will be explored therein--with special emphasis on the regulatory role of cytokines.

Authors+Show Affiliations

Department of Biology and Biomedical Sciences [corrected] Faculty of Arts and Sciences, Lebanese International University [corrected] Beirut, Lebanon. johnjhaddad@yahoo.co.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15683844

Citation

Haddad, John J., and Hisham L. Harb. "Cytokines and the Regulation of Hypoxia-inducible Factor (HIF)-1alpha." International Immunopharmacology, vol. 5, no. 3, 2005, pp. 461-83.
Haddad JJ, Harb HL. Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. Int Immunopharmacol. 2005;5(3):461-83.
Haddad, J. J., & Harb, H. L. (2005). Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. International Immunopharmacology, 5(3), 461-83.
Haddad JJ, Harb HL. Cytokines and the Regulation of Hypoxia-inducible Factor (HIF)-1alpha. Int Immunopharmacol. 2005;5(3):461-83. PubMed PMID: 15683844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. AU - Haddad,John J, AU - Harb,Hisham L, PY - 2004/08/06/received PY - 2004/09/27/revised PY - 2004/11/11/accepted PY - 2005/2/3/pubmed PY - 2005/9/24/medline PY - 2005/2/3/entrez SP - 461 EP - 83 JF - International immunopharmacology JO - Int Immunopharmacol VL - 5 IS - 3 N2 - Hypoxia-inducible factor (HIF)--an oxygen sensor? The HIF-oxygen sensing association type of dogma is, unequivocally, well anchored. But this is only one face of, at least, a double-sided coin. Current concepts charge HIF of taking sides with a yet not well-founded identity--an immunologic sensor and/or regulator. Or, is it really a sensor, put it more correctly, a key player in sensing mechanisms? The evolving association between HIF and immunity emanates from an established linkage that bonds oxidative stress and inflammation--notably the 'biologic response modifiers', or cytokines. HIF is a redox(y)-sensitive transcription factor, and so are cytokines. Recently, cytokines emerged as major regulators of HIF, under physiologic conditions extending the realm of hypoxia. Alternatively, can HIF, like the so infamous inflammatory transcription factor NF-(kappa)B, prove itself as a key player in the regulation of cytokines and, subsequently, the inflammatory process. The targeting of HIF would be, at least theoretically, of therapeutic value, but does it make sense given its intricate role in hypoxia signaling? It is the theme of HIF being an immunologic sensor that will be explored therein--with special emphasis on the regulatory role of cytokines. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/15683844/Cytokines_and_the_regulation_of_hypoxia_inducible_factor__HIF__1alpha_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(04)00380-7 DB - PRIME DP - Unbound Medicine ER -