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Specific fatty acid intake and the risk of pancreatic cancer in Canada.

Abstract

The possible association of specific fatty acid (FA) intake and pancreatic cancer risk was investigated in a population-based case-control study of 462 histologically confirmed cases and 4721 frequency-matched controls in eight Canadian provinces between 1994 and 1997. Dietary intake was assessed by means of a self-administered food frequency questionnaire. Unconditional logistic regression was used to assess associations between dietary FAs and pancreatic cancer risk. After adjustment for age, province, body mass index, smoking, educational attainment, fat and total energy intake, statistically significant inverse associations were observed between pancreatic cancer risk and palmitate (odds ratios (ORs)=0.73; 95% confidence intervals (CIs) 0.56-0.96; P-trend=0.02), stearate (OR=0.70; 95% CI 0.51-0.94; P-trend=0.04), oleate (OR=0.75; 95% CI 0.55-1.02; P-trend=0.04), saturated FAs (OR=0.67; 95% CI 0.50-0.91; P-trend=0.01), and monounsaturated FAs (OR=0.72; 95% CI 0.53-0.98; P-trend=0.02), when comparing the highest quartile of intake to the lowest. Significant interactions were detected between body mass index and both saturated and monounsaturated FAs, with a markedly reduced risk associated with intake of stearate (OR=0.36; 95% CI 0.18-0.70; P-trend=0.001), oleate (OR=0.36; 95% CI 0.19-0.72; P-trend=0.002), saturated FAs (OR=0.35; 95% CI 0.18-0.67; P-trend=0.002), and monounsaturated FAs (OR=0.32; 95% CI 0.16-0.63; P-trend<0.0001) among subjects who are obese. The results suggest that substituting polyunsaturated FAs with saturated or monounsaturated FAs may reduce pancreatic cancer risk, independently of total energy intake, particularly among obese subjects.

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  • Authors+Show Affiliations

    ,

    Epidemiology Research Unit, Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)-Hôtel-Dieu, Montreal, QC, Canada.

    , , ,

    Source

    British journal of cancer 92:5 2005 Mar 14 pg 971-7

    MeSH

    Canada
    Dietary Fats
    Fatty Acids
    Fatty Acids, Nonesterified
    Feeding Behavior
    Humans
    Pancreatic Neoplasms
    Registries
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15685231

    Citation

    Nkondjock, A, et al. "Specific Fatty Acid Intake and the Risk of Pancreatic Cancer in Canada." British Journal of Cancer, vol. 92, no. 5, 2005, pp. 971-7.
    Nkondjock A, Krewski D, Johnson KC, et al. Specific fatty acid intake and the risk of pancreatic cancer in Canada. Br J Cancer. 2005;92(5):971-7.
    Nkondjock, A., Krewski, D., Johnson, K. C., & Ghadirian, P. (2005). Specific fatty acid intake and the risk of pancreatic cancer in Canada. British Journal of Cancer, 92(5), pp. 971-7.
    Nkondjock A, et al. Specific Fatty Acid Intake and the Risk of Pancreatic Cancer in Canada. Br J Cancer. 2005 Mar 14;92(5):971-7. PubMed PMID: 15685231.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Specific fatty acid intake and the risk of pancreatic cancer in Canada. AU - Nkondjock,A, AU - Krewski,D, AU - Johnson,K C, AU - Ghadirian,P, AU - ,, PY - 2005/2/3/pubmed PY - 2005/4/22/medline PY - 2005/2/3/entrez SP - 971 EP - 7 JF - British journal of cancer JO - Br. J. Cancer VL - 92 IS - 5 N2 - The possible association of specific fatty acid (FA) intake and pancreatic cancer risk was investigated in a population-based case-control study of 462 histologically confirmed cases and 4721 frequency-matched controls in eight Canadian provinces between 1994 and 1997. Dietary intake was assessed by means of a self-administered food frequency questionnaire. Unconditional logistic regression was used to assess associations between dietary FAs and pancreatic cancer risk. After adjustment for age, province, body mass index, smoking, educational attainment, fat and total energy intake, statistically significant inverse associations were observed between pancreatic cancer risk and palmitate (odds ratios (ORs)=0.73; 95% confidence intervals (CIs) 0.56-0.96; P-trend=0.02), stearate (OR=0.70; 95% CI 0.51-0.94; P-trend=0.04), oleate (OR=0.75; 95% CI 0.55-1.02; P-trend=0.04), saturated FAs (OR=0.67; 95% CI 0.50-0.91; P-trend=0.01), and monounsaturated FAs (OR=0.72; 95% CI 0.53-0.98; P-trend=0.02), when comparing the highest quartile of intake to the lowest. Significant interactions were detected between body mass index and both saturated and monounsaturated FAs, with a markedly reduced risk associated with intake of stearate (OR=0.36; 95% CI 0.18-0.70; P-trend=0.001), oleate (OR=0.36; 95% CI 0.19-0.72; P-trend=0.002), saturated FAs (OR=0.35; 95% CI 0.18-0.67; P-trend=0.002), and monounsaturated FAs (OR=0.32; 95% CI 0.16-0.63; P-trend<0.0001) among subjects who are obese. The results suggest that substituting polyunsaturated FAs with saturated or monounsaturated FAs may reduce pancreatic cancer risk, independently of total energy intake, particularly among obese subjects. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/15685231/Specific_fatty_acid_intake_and_the_risk_of_pancreatic_cancer_in_Canada_ L2 - http://dx.doi.org/10.1038/sj.bjc.6602380 DB - PRIME DP - Unbound Medicine ER -