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Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays.
J Agric Food Chem. 2005 Feb 09; 53(3):816-22.JA

Abstract

Ethanol-water (70:30 v/v) extracts from rice brans removed from seeds of two blackish-purple pigmented (Sanhaehyanghyulla and Suwon 415) and one nonpigmented (Chuchung) brown rice cultivars were evaluated for antioxidative, anti-tumor-promoting, and anticarcinogenic activities in chemical assays and in mammalian cells (human leukemia HL-60, marmoset B lymphoblastoid B95-8, and Chinese hamster V79 lung cells) by the following tests: inhibition of xanthine oxidase activity; chelation of ferrous ions; reduction of potassium ferricyanide; scavenging of superoxide anions, hydroxyl radicals, and intracellular peroxides; inhibition of 4-nitroquinoline N-oxide-induced mutagenesis; and inhibition of phorbol ester-induced tumor promotion. The extracts from the pigmented rice seeds had generally higher activities in all tests than did the extract from the nonpigmented variety. The results suggest that brans from pigmented rice varieties may provide a source of new natural antioxidants and anticarcinogens and that such rice cultivars with high antioxidative potential also provide a genetic resource for the development of new, improved rice cultivars that may make it possible to enhance both the nutritional and medical value of rice-based diets.

Authors+Show Affiliations

Department of Biological Science, Ajou University, Suwon 443-749, Korea. shnam@ajou.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15686439

Citation

Nam, Seok Hyun, et al. "Antioxidative, Antimutagenic, and Anticarcinogenic Activities of Rice Bran Extracts in Chemical and Cell Assays." Journal of Agricultural and Food Chemistry, vol. 53, no. 3, 2005, pp. 816-22.
Nam SH, Choi SP, Kang MY, et al. Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays. J Agric Food Chem. 2005;53(3):816-22.
Nam, S. H., Choi, S. P., Kang, M. Y., Kozukue, N., & Friedman, M. (2005). Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays. Journal of Agricultural and Food Chemistry, 53(3), 816-22.
Nam SH, et al. Antioxidative, Antimutagenic, and Anticarcinogenic Activities of Rice Bran Extracts in Chemical and Cell Assays. J Agric Food Chem. 2005 Feb 9;53(3):816-22. PubMed PMID: 15686439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays. AU - Nam,Seok Hyun, AU - Choi,Sun Phil, AU - Kang,Mi Young, AU - Kozukue,Nobuyuki, AU - Friedman,Mendel, PY - 2005/2/3/pubmed PY - 2005/3/23/medline PY - 2005/2/3/entrez SP - 816 EP - 22 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 53 IS - 3 N2 - Ethanol-water (70:30 v/v) extracts from rice brans removed from seeds of two blackish-purple pigmented (Sanhaehyanghyulla and Suwon 415) and one nonpigmented (Chuchung) brown rice cultivars were evaluated for antioxidative, anti-tumor-promoting, and anticarcinogenic activities in chemical assays and in mammalian cells (human leukemia HL-60, marmoset B lymphoblastoid B95-8, and Chinese hamster V79 lung cells) by the following tests: inhibition of xanthine oxidase activity; chelation of ferrous ions; reduction of potassium ferricyanide; scavenging of superoxide anions, hydroxyl radicals, and intracellular peroxides; inhibition of 4-nitroquinoline N-oxide-induced mutagenesis; and inhibition of phorbol ester-induced tumor promotion. The extracts from the pigmented rice seeds had generally higher activities in all tests than did the extract from the nonpigmented variety. The results suggest that brans from pigmented rice varieties may provide a source of new natural antioxidants and anticarcinogens and that such rice cultivars with high antioxidative potential also provide a genetic resource for the development of new, improved rice cultivars that may make it possible to enhance both the nutritional and medical value of rice-based diets. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15686439/Antioxidative_antimutagenic_and_anticarcinogenic_activities_of_rice_bran_extracts_in_chemical_and_cell_assays_ L2 - https://doi.org/10.1021/jf0490293 DB - PRIME DP - Unbound Medicine ER -