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Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients.
Transplant Proc. 2004 Dec; 36(10):2979-81.TP

Abstract

Hyperhomocysteine has been reported to be an important risk factor for the development of atherosclerosis. Identification of risk factors, such as hyperhomocysteinemia, is crucial for a better understanding of the events that lead to degenerative processes in the vascular system and for a correct understanding of the potential role of methylene-tetrahydrofolate reductase enzymes (MTHFR) to help in the treatment of vascular disease observed in chronic allograft nephropathy (CAN). In this study we analyzed the plasma homocysteine concentrations and MTHFR C677T and A1298C polymorphism frequencies among 110 renal transplant recipients (53 with CAN and 57 with normal renal function). All recipients had undergone renal transplantation at least 12 months prior to this investigation to establish a possible correlation with the posttransplant outcome. Plasma homocysteine concentrations were measured by liquid chromatography-tandem mass spectrometry and MTHFR polymorphisms were investigated by the PCR-RFLP technique. The results demonstrated that in renal transplant recipients, hyperhomocysteinemia in addition to the presence of the allelic variants for both MTHFR polymorphisms (677T/1298C) might play a role as an additional risk factor for CAN. We understand that analysis of these polymorphisms might have a role in the CAN process. Therefore, studies to evaluate their presence in renal transplant patients may be extremely useful to individualize immunosuppressive protocols to inhibit or retard the progression of CAN.

Authors+Show Affiliations

Department of Molecular Biology, UNICAMP, Campinas, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15686674

Citation

Pavarino-Bertelli, E C., et al. "Hyperhomocysteinemia and MTHFR C677T and A1298C Polymorphisms Are Associated With Chronic Allograft Nephropathy in Renal Transplant Recipients." Transplantation Proceedings, vol. 36, no. 10, 2004, pp. 2979-81.
Pavarino-Bertelli EC, Sanches de Alvarenga MP, Goloni-Bertollo EM, et al. Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients. Transplant Proc. 2004;36(10):2979-81.
Pavarino-Bertelli, E. C., Sanches de Alvarenga, M. P., Goloni-Bertollo, E. M., Baptista, M. A., Haddad, R., Hoerh, N. F., Eberlin, M. N., & Abbud-Filho, M. (2004). Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients. Transplantation Proceedings, 36(10), 2979-81.
Pavarino-Bertelli EC, et al. Hyperhomocysteinemia and MTHFR C677T and A1298C Polymorphisms Are Associated With Chronic Allograft Nephropathy in Renal Transplant Recipients. Transplant Proc. 2004;36(10):2979-81. PubMed PMID: 15686674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients. AU - Pavarino-Bertelli,E C, AU - Sanches de Alvarenga,M P, AU - Goloni-Bertollo,E M, AU - Baptista,M A S F, AU - Haddad,R, AU - Hoerh,N F, AU - Eberlin,M N, AU - Abbud-Filho,M, PY - 2005/2/3/pubmed PY - 2005/7/8/medline PY - 2005/2/3/entrez SP - 2979 EP - 81 JF - Transplantation proceedings JO - Transplant Proc VL - 36 IS - 10 N2 - Hyperhomocysteine has been reported to be an important risk factor for the development of atherosclerosis. Identification of risk factors, such as hyperhomocysteinemia, is crucial for a better understanding of the events that lead to degenerative processes in the vascular system and for a correct understanding of the potential role of methylene-tetrahydrofolate reductase enzymes (MTHFR) to help in the treatment of vascular disease observed in chronic allograft nephropathy (CAN). In this study we analyzed the plasma homocysteine concentrations and MTHFR C677T and A1298C polymorphism frequencies among 110 renal transplant recipients (53 with CAN and 57 with normal renal function). All recipients had undergone renal transplantation at least 12 months prior to this investigation to establish a possible correlation with the posttransplant outcome. Plasma homocysteine concentrations were measured by liquid chromatography-tandem mass spectrometry and MTHFR polymorphisms were investigated by the PCR-RFLP technique. The results demonstrated that in renal transplant recipients, hyperhomocysteinemia in addition to the presence of the allelic variants for both MTHFR polymorphisms (677T/1298C) might play a role as an additional risk factor for CAN. We understand that analysis of these polymorphisms might have a role in the CAN process. Therefore, studies to evaluate their presence in renal transplant patients may be extremely useful to individualize immunosuppressive protocols to inhibit or retard the progression of CAN. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/15686674/Hyperhomocysteinemia_and_MTHFR_C677T_and_A1298C_polymorphisms_are_associated_with_chronic_allograft_nephropathy_in_renal_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(04)01439-3 DB - PRIME DP - Unbound Medicine ER -