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Gene expression and adiposity are modified by soy protein in male Zucker diabetic fatty rats.
Obes Res. 2004 Dec; 12(12):1907-13.OR

Abstract

It has earlier been demonstrated that soy protein diets ameliorate the diabetic phenotype in obese Zucker rats. In this study, we further investigated physiological changes related to adiposity in male Zucker diabetic fatty rats consuming soy-based diets and compared these diets with the insulin-sensitizing drug, rosiglitazone. Transcript abundance of known genes was assessed in the livers to identify potential molecular connections between soy diets and adiposity. Male Zucker diabetic fatty rats were assigned to casein (C) protein, low-isoflavone soy (LIS) protein, high-isoflavone soy (HIS) protein, or C + rosiglitazone (CR) diets. Compared with the C diet, the LIS diet decreased plasma lipids and increased body weight, but did not change liver weight or carcass adiposity. HIS decreased plasma lipids, liver weight, and body weight. CR decreased plasma lipids and increased carcass adiposity and body weight with no effect on liver weight. In LIS livers, 15 genes involved in signaling and lipid metabolism were up-regulated 2-fold or higher. In HIS livers, seven genes had a 2-fold or higher change in abundance. However, in CR livers, none of the genes was significantly changed compared with the C diet. There appears to be a distinct change in gene expression associated with soy diets as compared with C-based diets and rosiglitazone treatment.

Authors+Show Affiliations

Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901-4317, USA. banz@siu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15687389

Citation

Banz, William J., et al. "Gene Expression and Adiposity Are Modified By Soy Protein in Male Zucker Diabetic Fatty Rats." Obesity Research, vol. 12, no. 12, 2004, pp. 1907-13.
Banz WJ, Davis J, Peterson R, et al. Gene expression and adiposity are modified by soy protein in male Zucker diabetic fatty rats. Obes Res. 2004;12(12):1907-13.
Banz, W. J., Davis, J., Peterson, R., & Iqbal, M. J. (2004). Gene expression and adiposity are modified by soy protein in male Zucker diabetic fatty rats. Obesity Research, 12(12), 1907-13.
Banz WJ, et al. Gene Expression and Adiposity Are Modified By Soy Protein in Male Zucker Diabetic Fatty Rats. Obes Res. 2004;12(12):1907-13. PubMed PMID: 15687389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene expression and adiposity are modified by soy protein in male Zucker diabetic fatty rats. AU - Banz,William J, AU - Davis,Jeremy, AU - Peterson,Richard, AU - Iqbal,Muhammad J, PY - 2005/2/3/pubmed PY - 2005/5/27/medline PY - 2005/2/3/entrez SP - 1907 EP - 13 JF - Obesity research JO - Obes. Res. VL - 12 IS - 12 N2 - It has earlier been demonstrated that soy protein diets ameliorate the diabetic phenotype in obese Zucker rats. In this study, we further investigated physiological changes related to adiposity in male Zucker diabetic fatty rats consuming soy-based diets and compared these diets with the insulin-sensitizing drug, rosiglitazone. Transcript abundance of known genes was assessed in the livers to identify potential molecular connections between soy diets and adiposity. Male Zucker diabetic fatty rats were assigned to casein (C) protein, low-isoflavone soy (LIS) protein, high-isoflavone soy (HIS) protein, or C + rosiglitazone (CR) diets. Compared with the C diet, the LIS diet decreased plasma lipids and increased body weight, but did not change liver weight or carcass adiposity. HIS decreased plasma lipids, liver weight, and body weight. CR decreased plasma lipids and increased carcass adiposity and body weight with no effect on liver weight. In LIS livers, 15 genes involved in signaling and lipid metabolism were up-regulated 2-fold or higher. In HIS livers, seven genes had a 2-fold or higher change in abundance. However, in CR livers, none of the genes was significantly changed compared with the C diet. There appears to be a distinct change in gene expression associated with soy diets as compared with C-based diets and rosiglitazone treatment. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15687389/Gene_expression_and_adiposity_are_modified_by_soy_protein_in_male_Zucker_diabetic_fatty_rats_ L2 - https://doi.org/10.1038/oby.2004.238 DB - PRIME DP - Unbound Medicine ER -