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Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats.
Neuropsychopharmacology 2005; 30(7):1312-23N

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) produces acute dopamine and 5-HT release in rat brain and a hyperthermic response, which is dependent on the ambient room temperature in which the animal is housed. We examined the effect of ambient room temperature (20 and 30 degrees C) on MDMA-induced dopamine and 5-HT efflux in the striatum and shell of nucleus accumbens (NAc) of freely moving rats by using microdialysis. Locomotor activity and rectal temperature were also evaluated. In the NAc, MDMA (2.5 or 5 mg/kg, i.p.) produced a substantial increase in extracellular dopamine, which was more marked at 30 degrees C. 5-HT release was also increased by MDMA given at 30 degrees C. In contrast, MDMA-induced extracellular dopamine and 5-HT increases in the striatum were unaffected by ambient temperature. At 20 degrees C room temperature, MDMA did not modify the rectal temperature but at 30 degrees C it produced a rapid and sustained hyperthermia. MDMA at 20 degrees C room temperature produced a two-fold increase in activity compared with saline-treated controls. The MDMA-induced increase in locomotor activity was more marked at 30 degrees C due to a decrease in the activity of the saline-treated controls at this high ambient temperature. These results show that high ambient temperature enhances MDMA-induced locomotor activity and monoamine release in the shell of NAc, a region involved in the incentive motivational properties of drugs of abuse, and suggest that the rewarding effects of MDMA may be more pronounced at high ambient temperature.

Authors+Show Affiliations

Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15688085

Citation

O'Shea, Esther, et al. "Elevation of Ambient Room Temperature Has Differential Effects On MDMA-induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 30, no. 7, 2005, pp. 1312-23.
O'Shea E, Escobedo I, Orio L, et al. Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology. 2005;30(7):1312-23.
O'Shea, E., Escobedo, I., Orio, L., Sanchez, V., Navarro, M., Green, A. R., & Colado, M. I. (2005). Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 30(7), pp. 1312-23.
O'Shea E, et al. Elevation of Ambient Room Temperature Has Differential Effects On MDMA-induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats. Neuropsychopharmacology. 2005;30(7):1312-23. PubMed PMID: 15688085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. AU - O'Shea,Esther, AU - Escobedo,Isabel, AU - Orio,Laura, AU - Sanchez,Veronica, AU - Navarro,Miguel, AU - Green,A Richard, AU - Colado,M Isabel, PY - 2005/2/3/pubmed PY - 2005/8/10/medline PY - 2005/2/3/entrez SP - 1312 EP - 23 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 30 IS - 7 N2 - 3,4-Methylenedioxymethamphetamine (MDMA) produces acute dopamine and 5-HT release in rat brain and a hyperthermic response, which is dependent on the ambient room temperature in which the animal is housed. We examined the effect of ambient room temperature (20 and 30 degrees C) on MDMA-induced dopamine and 5-HT efflux in the striatum and shell of nucleus accumbens (NAc) of freely moving rats by using microdialysis. Locomotor activity and rectal temperature were also evaluated. In the NAc, MDMA (2.5 or 5 mg/kg, i.p.) produced a substantial increase in extracellular dopamine, which was more marked at 30 degrees C. 5-HT release was also increased by MDMA given at 30 degrees C. In contrast, MDMA-induced extracellular dopamine and 5-HT increases in the striatum were unaffected by ambient temperature. At 20 degrees C room temperature, MDMA did not modify the rectal temperature but at 30 degrees C it produced a rapid and sustained hyperthermia. MDMA at 20 degrees C room temperature produced a two-fold increase in activity compared with saline-treated controls. The MDMA-induced increase in locomotor activity was more marked at 30 degrees C due to a decrease in the activity of the saline-treated controls at this high ambient temperature. These results show that high ambient temperature enhances MDMA-induced locomotor activity and monoamine release in the shell of NAc, a region involved in the incentive motivational properties of drugs of abuse, and suggest that the rewarding effects of MDMA may be more pronounced at high ambient temperature. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/15688085/Elevation_of_ambient_room_temperature_has_differential_effects_on_MDMA_induced_5_HT_and_dopamine_release_in_striatum_and_nucleus_accumbens_of_rats_ L2 - http://dx.doi.org/10.1038/sj.npp.1300673 DB - PRIME DP - Unbound Medicine ER -