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[Zollinger-Ellison syndrome].
Chirurg. 2005 Mar; 76(3):217-26.C

Abstract

The preoperative localization of gastrinomas often fails despite all modern imaging methods. Therefore, after biochemical confirmation of the diagnosis and exclusion of diffuse metastases, a meticulous surgical exploration including intraoperative ultrasound (IOUS) and duodenal exploration after duodenotomy should be performed. The experienced surgeon will be able to identify more than 90% of the primary tumors. Depending on the localization, excision of the tumor in the duodenal wall or enucleation from the pancreatic head should be performed. If the tumor is localized in the tail of the pancreas, distal pancreatectomy is the treatment of choice. Complete resection of the tumor is the only curative approach for the patients. For MEN-1 gastrinomas a spleen-preserving distal pancreatectomy with enucleation of tumors of the pancreatic head and duodenotomy with excision of duodenal gastrinomas should be performed. If the source of gastrin secretion can be regionalized to the pancreatic head by a preoperative SASI angiography, a pylorus-preserving partial pancreaticoduodenectomy might be the treatment of choice.

Authors+Show Affiliations

Klinik für Visceral-, Thorax- und Gefässchirurgie, Philipps-Universität Marburg. fendrich@med.uni-marburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

15688179

Citation

Fendrich, V, et al. "[Zollinger-Ellison Syndrome]." Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen, vol. 76, no. 3, 2005, pp. 217-26.
Fendrich V, Bartsch DK, Langer P, et al. [Zollinger-Ellison syndrome]. Chirurg. 2005;76(3):217-26.
Fendrich, V., Bartsch, D. K., Langer, P., Zielke, A., & Rothmund, M. (2005). [Zollinger-Ellison syndrome]. Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen, 76(3), 217-26.
Fendrich V, et al. [Zollinger-Ellison Syndrome]. Chirurg. 2005;76(3):217-26. PubMed PMID: 15688179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Zollinger-Ellison syndrome]. AU - Fendrich,V, AU - Bartsch,D K, AU - Langer,P, AU - Zielke,A, AU - Rothmund,M, PY - 2005/2/3/pubmed PY - 2005/7/22/medline PY - 2005/2/3/entrez SP - 217 EP - 26 JF - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen JO - Chirurg VL - 76 IS - 3 N2 - The preoperative localization of gastrinomas often fails despite all modern imaging methods. Therefore, after biochemical confirmation of the diagnosis and exclusion of diffuse metastases, a meticulous surgical exploration including intraoperative ultrasound (IOUS) and duodenal exploration after duodenotomy should be performed. The experienced surgeon will be able to identify more than 90% of the primary tumors. Depending on the localization, excision of the tumor in the duodenal wall or enucleation from the pancreatic head should be performed. If the tumor is localized in the tail of the pancreas, distal pancreatectomy is the treatment of choice. Complete resection of the tumor is the only curative approach for the patients. For MEN-1 gastrinomas a spleen-preserving distal pancreatectomy with enucleation of tumors of the pancreatic head and duodenotomy with excision of duodenal gastrinomas should be performed. If the source of gastrin secretion can be regionalized to the pancreatic head by a preoperative SASI angiography, a pylorus-preserving partial pancreaticoduodenectomy might be the treatment of choice. SN - 0009-4722 UR - https://www.unboundmedicine.com/medline/citation/15688179/[Zollinger_Ellison_syndrome]_ L2 - https://dx.doi.org/10.1007/s00104-004-0995-5 DB - PRIME DP - Unbound Medicine ER -