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Are new vitamin D analogues in renal bone disease superior to calcitriol?
Pediatr Nephrol. 2005 Mar; 20(3):393-8.PN

Abstract

Progression of chronic kidney disease is associated with an early reduction in serum calcitriol levels; thus, therapy with calcitriol should be initiated early in the course of chronic kidney disease to prevent the development of secondary hyperparathyroidism. Initial studies demonstrated a potential role of calcitriol in the prevention of growth retardation in children with chronic kidney disease prior to dialysis. But the optimal parathyroid hormone (PTH) levels that will maximize growth response during calcitriol treatment remain to be defined. Therapy with calcitriol has been shown to control the biochemical and skeletal manifestations of secondary hyperparathyroidism, but patients developed hypercalcemia, hyperphosphatemia and adynamic osteodystrophy. Thus, new vitamin D analogues with a lower hypercalcemic response have been developed. Although comparative studies are lacking, current evidence indicates that these new active vitamin D sterols (19-nor-paracalcitol and doxercalciferol) adequately control secondary hyperparathyroidism with minimal changes in serum calcium and phosphorus levels during treatment with calcium-containing binders. The long-term effect of such therapies on the skeleton and the process of vascular calcifications remain to be evaluated.

Authors+Show Affiliations

Department of Pediatrics, Division of Pediatric Nephrology, David Geffen School of Medicine at UCLA, Box 951752, Los Angeles, CA 90095, USA. isalusky@mednet.ucla.edu

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15690188

Citation

Salusky, Isidro B.. "Are New Vitamin D Analogues in Renal Bone Disease Superior to Calcitriol?" Pediatric Nephrology (Berlin, Germany), vol. 20, no. 3, 2005, pp. 393-8.
Salusky IB. Are new vitamin D analogues in renal bone disease superior to calcitriol? Pediatr Nephrol. 2005;20(3):393-8.
Salusky, I. B. (2005). Are new vitamin D analogues in renal bone disease superior to calcitriol? Pediatric Nephrology (Berlin, Germany), 20(3), 393-8.
Salusky IB. Are New Vitamin D Analogues in Renal Bone Disease Superior to Calcitriol. Pediatr Nephrol. 2005;20(3):393-8. PubMed PMID: 15690188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are new vitamin D analogues in renal bone disease superior to calcitriol? A1 - Salusky,Isidro B, Y1 - 2005/02/03/ PY - 2004/06/02/received PY - 2004/11/09/accepted PY - 2004/11/08/revised PY - 2005/2/4/pubmed PY - 2005/10/19/medline PY - 2005/2/4/entrez SP - 393 EP - 8 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 20 IS - 3 N2 - Progression of chronic kidney disease is associated with an early reduction in serum calcitriol levels; thus, therapy with calcitriol should be initiated early in the course of chronic kidney disease to prevent the development of secondary hyperparathyroidism. Initial studies demonstrated a potential role of calcitriol in the prevention of growth retardation in children with chronic kidney disease prior to dialysis. But the optimal parathyroid hormone (PTH) levels that will maximize growth response during calcitriol treatment remain to be defined. Therapy with calcitriol has been shown to control the biochemical and skeletal manifestations of secondary hyperparathyroidism, but patients developed hypercalcemia, hyperphosphatemia and adynamic osteodystrophy. Thus, new vitamin D analogues with a lower hypercalcemic response have been developed. Although comparative studies are lacking, current evidence indicates that these new active vitamin D sterols (19-nor-paracalcitol and doxercalciferol) adequately control secondary hyperparathyroidism with minimal changes in serum calcium and phosphorus levels during treatment with calcium-containing binders. The long-term effect of such therapies on the skeleton and the process of vascular calcifications remain to be evaluated. SN - 0931-041X UR - https://www.unboundmedicine.com/medline/citation/15690188/Are_new_vitamin_D_analogues_in_renal_bone_disease_superior_to_calcitriol L2 - https://dx.doi.org/10.1007/s00467-004-1788-2 DB - PRIME DP - Unbound Medicine ER -