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Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea.
Metabolism. 2005 Feb; 54(2):206-11.M

Abstract

Homeostasis model assessment of insulin resistance (HOMA-IR) is a less invasive, inexpensive, and less labor-intensive method to measure insulin resistance (IR) as compared with the glucose clamp test. The aim of this study was to evaluate the validity of HOMA-IR by comparing it with the euglycemic clamp test in determining IR. We assessed the validity of HOMA-IR by comparing it with the total glucose disposal rate measured by the 3-hour euglycemic-hyperinsulinemic clamp in subjects with type 2 diabetes (n = 47), impaired glucose tolerance (n = 21), and normal glucose tolerance (n = 22). There was a strong inverse correlation (r = -0.558; P < .001) between the log-transformed HOMA-IR and the total glucose disposal rate. There was moderate agreement between the 2 methods in the categorization according to the IR (weighted kappa = 0.294). The magnitude of the correlation coefficients was smaller in the subjects with a lower body mass index (BMI <25.0 kg/m2 , r = -0.441 vs BMI > or =25.0 kg/m2 , r = -0.615; P = .032), a lower HOMA-beta cell function (HOMA- beta <60.0, r = -0.527 vs HOMA- beta > or =60.0, r = -0.686; P = .016), and higher fasting glucose levels (fasting glucose < or =5.66 mmol/L, r = -0.556 vs fasting glucose >5.66 mmol/L, r = -0.520; P = .039). The limitation of the validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, a lower beta cell function, and high fasting glucose levels such as lean type 2 diabetes mellitus with insulin secretory defects.

Authors+Show Affiliations

Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine, Seoul 120-752, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15690315

Citation

Kang, Eun Seok, et al. "Limitation of the Validity of the Homeostasis Model Assessment as an Index of Insulin Resistance in Korea." Metabolism: Clinical and Experimental, vol. 54, no. 2, 2005, pp. 206-11.
Kang ES, Yun YS, Park SW, et al. Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. Metabolism. 2005;54(2):206-11.
Kang, E. S., Yun, Y. S., Park, S. W., Kim, H. J., Ahn, C. W., Song, Y. D., Cha, B. S., Lim, S. K., Kim, K. R., & Lee, H. C. (2005). Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. Metabolism: Clinical and Experimental, 54(2), 206-11.
Kang ES, et al. Limitation of the Validity of the Homeostasis Model Assessment as an Index of Insulin Resistance in Korea. Metabolism. 2005;54(2):206-11. PubMed PMID: 15690315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. AU - Kang,Eun Seok, AU - Yun,Yong Seok, AU - Park,Seok Won, AU - Kim,Hyeung Jin, AU - Ahn,Chul Woo, AU - Song,Young Duk, AU - Cha,Bong Soo, AU - Lim,Sung Kil, AU - Kim,Kyung Rae, AU - Lee,Hyun Chul, PY - 2005/2/4/pubmed PY - 2005/3/30/medline PY - 2005/2/4/entrez SP - 206 EP - 11 JF - Metabolism: clinical and experimental JO - Metabolism VL - 54 IS - 2 N2 - Homeostasis model assessment of insulin resistance (HOMA-IR) is a less invasive, inexpensive, and less labor-intensive method to measure insulin resistance (IR) as compared with the glucose clamp test. The aim of this study was to evaluate the validity of HOMA-IR by comparing it with the euglycemic clamp test in determining IR. We assessed the validity of HOMA-IR by comparing it with the total glucose disposal rate measured by the 3-hour euglycemic-hyperinsulinemic clamp in subjects with type 2 diabetes (n = 47), impaired glucose tolerance (n = 21), and normal glucose tolerance (n = 22). There was a strong inverse correlation (r = -0.558; P < .001) between the log-transformed HOMA-IR and the total glucose disposal rate. There was moderate agreement between the 2 methods in the categorization according to the IR (weighted kappa = 0.294). The magnitude of the correlation coefficients was smaller in the subjects with a lower body mass index (BMI <25.0 kg/m2 , r = -0.441 vs BMI > or =25.0 kg/m2 , r = -0.615; P = .032), a lower HOMA-beta cell function (HOMA- beta <60.0, r = -0.527 vs HOMA- beta > or =60.0, r = -0.686; P = .016), and higher fasting glucose levels (fasting glucose < or =5.66 mmol/L, r = -0.556 vs fasting glucose >5.66 mmol/L, r = -0.520; P = .039). The limitation of the validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, a lower beta cell function, and high fasting glucose levels such as lean type 2 diabetes mellitus with insulin secretory defects. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/15690315/Limitation_of_the_validity_of_the_homeostasis_model_assessment_as_an_index_of_insulin_resistance_in_Korea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049504003324 DB - PRIME DP - Unbound Medicine ER -